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The map label for this gene is bfmBAA [H]

Identifier: 57650474

GI number: 57650474

Start: 1597526

End: 1598518

Strand: Reverse

Name: bfmBAA [H]

Synonym: SACOL1562

Alternate gene names: 57650474

Gene position: 1598518-1597526 (Counterclockwise)

Preceding gene: 57650475

Following gene: 57650473

Centisome position: 56.9

GC content: 38.27

Gene sequence:

>993_bases
ATGATTGATTATAAATCATTAGGCCTTAGCGAAGAAGACCTAAAAGTAATATATAAATGGATGGATTTAGGTAGAAAAAT
AGATGAAAGACTGTGGTTATTGAACCGTGCAGGTAAAATTCCATTTGTTGTAAGTGGTCAAGGACAAGAAGCAACTCAGA
TTGGGATGGCATACGCATTAGAAGAAGGTGATATTACAGCGCCTTATTATAGAGATCTAGCTTTCGTTACTTATATGGGT
ATCTCAGCGTATGATACGTTTTTATCAGCGTTTGGAAAGAAAGACGATGTTAACTCTGGTGGAAAACAAATGCCATCACA
CTTTAGTAGTAGAGCTAAGAATATTTTGTCTCAAAGTTCACCGGTAGCAACTCAAATACCCCATGCTGTTGGTGCTGCTT
TAGCTTTAAAAATGGATGGTAAGAAGAAAATTGCAACAGCAACTGTTGGTGAAGGTAGCTCAAACCAAGGTGACTTCCAT
GAAGGTTTAAACTTCGCGGGTGTACACAAACTTCCTTTTGTATGTGTCATTATAAATAATAAATATGCAATTTCAGTACC
TGATTCATTACAATACGCAGCTGAAAAATTATCGGATAGAGCACTTGGTTACGGTATACATGGTGAACAAGTAGATGGTA
ATGATCCATTAGCAATGTATAAAGCGATGAAAGAAGCAAGAGATCGAGCTATTTCTGGTCAAGGTTCAACTTTGATTGAA
GCAGTAACAAGTCGTATGACAGCTCATTCATCAGATGATGACGACCAATATCGTACGAAAGAAGAGCGTGAAACGCTTAA
AAAAGCAGACTGCAATGAAAAGTTCAAAAAAGAGTTGCTTTCAGCTGGCATTATCGATGATGCTTGGTTGGCAGAAATAG
AAGCGGAGCATAAAGACATCATCAATAAAGCGACAAAGGCTGCTGAAGACGCGCCATATCCAAGTGTCGAAGAAGCCTAT
GCATTTGTGTACGAAGAAGGGAGTCTTAACTAA

Upstream 100 bases:

>100_bases
ACTAACAACACACGCACATCCTTCCATCTCTGAAGTGTTGATGGAATTAGGATTGAAAGCAGAAAGTAGAGCTATTCACG
TATAAATAGGAGGATTTAAC

Downstream 100 bases:

>100_bases
TGGCTAAATTATCTTATTTAGAGGCGATACGCCAGGCACAAGACTTAGCATTACAACAAAATAAAGATGTGTTTATTCTT
GGTGAAGATGTTGGTAGAAA

Product: 2-oxoisovalerate dehydrogenase, E1 component subunit alpha

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN

Sequences:

>Translated_330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN
>Mature_330_residues
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYALEEGDITAPYYRDLAFVTYMG
ISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSSPVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFH
EGLNFAGVHKLPFVCVIINNKYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
AVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDIINKATKAAEDAPYPSVEEAY
AFVYEEGSLN

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=320, Percent_Identity=35.625, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI258645172, Length=320, Percent_Identity=35.625, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4505685, Length=319, Percent_Identity=30.0940438871473, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI291084742, Length=319, Percent_Identity=30.0940438871473, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI291084744, Length=326, Percent_Identity=29.1411042944785, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI4885543, Length=283, Percent_Identity=30.7420494699647, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI291084757, Length=171, Percent_Identity=32.7485380116959, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563355, Length=316, Percent_Identity=35.126582278481, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI86563357, Length=316, Percent_Identity=35.126582278481, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32564172, Length=323, Percent_Identity=30.3405572755418, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17536047, Length=323, Percent_Identity=30.3405572755418, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=29.9382716049383, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=34.8623853211009, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24639748, Length=319, Percent_Identity=27.8996865203762, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639746, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639740, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639744, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571106, Length=280, Percent_Identity=29.2857142857143, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36230; Mature: 36230

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
EEGDITAPYYRDLAFVTYMGISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFHEGLNFAGVHKLPFVCVIINN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEECC
KYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
INKATKAAEDAPYPSVEEAYAFVYEEGSLN
HHHHHHHHCCCCCCCHHHHHEEEECCCCCC
>Mature Secondary Structure
MIDYKSLGLSEEDLKVIYKWMDLGRKIDERLWLLNRAGKIPFVVSGQGQEATQIGMAYAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
EEGDITAPYYRDLAFVTYMGISAYDTFLSAFGKKDDVNSGGKQMPSHFSSRAKNILSQSS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVATQIPHAVGAALALKMDGKKKIATATVGEGSSNQGDFHEGLNFAGVHKLPFVCVIINN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCEEEEEECC
KYAISVPDSLQYAAEKLSDRALGYGIHGEQVDGNDPLAMYKAMKEARDRAISGQGSTLIE
EEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AVTSRMTAHSSDDDDQYRTKEERETLKKADCNEKFKKELLSAGIIDDAWLAEIEAEHKDI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
INKATKAAEDAPYPSVEEAYAFVYEEGSLN
HHHHHHHHCCCCCCCHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]