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The map label for this gene is arcB1

Identifier: 57650280

GI number: 57650280

Start: 1185397

End: 1186398

Strand: Direct

Name: arcB1

Synonym: SACOL1181

Alternate gene names: 57650280

Gene position: 1185397-1186398 (Clockwise)

Preceding gene: 57650276

Following gene: 57650281

Centisome position: 42.19

GC content: 33.73

Gene sequence:

>1002_bases
ATGAAAAATTTACGAAACAGAAGTTTTTTAACTTTATTAGACTTTTCACGACAAGAGGTAGAATTCTTATTAACACTCTC
CGAGGATTTAAAACGTGCTAAATATATTGGCACTGAAAAGCCTATGTTAAAAAATAAAAATATTGCACTGTTATTTGAAA
AAGATTCTACAAGAACGCGATGTGCATTTGAAGTTGCAGCGCATGATCAAGGTGCAAATGTAACTTATTTAGGCCCAACT
GGATCACAAATGGGTAAAAAAGAAACAACTAAAGATACTGCACGTGTGCTTGGTGGAATGTATGATGGCATTGAATACCG
TGGTTTTTCACAAAGAACAGTAGAAACTTTAGCTGAGTATTCAGGCGTACCAGTGTGGAATGGTTTAACTGATGAAGATC
ATCCTACTCAAGTTCTTGCTGATTTCTTAACAGCAAAAGAAGTCTTAAAAAAAGATTATGCAGATATTAACTTTACATAT
GTTGGAGATGGTCGTAATAACGTTGCAAATGCATTAATGCAAGGTGCTGCCATTATGGGTATGAACTTCCATTTAGTTTG
TCCAAAAGAATTAAATCCAACAGATGAATTATTAAATCGCTGTAAAAATATTGCCGCTGAAAATGGTGGCAACATATTAA
TCACAGATGATATTGACCAAGGTGTAAAAGGTTCGGATGTAATTTACACTGATGTTTGGGTATCAATGGGTGAACCTGAT
GAAGTATGGAAAGAACGACTTGAATTATTGAAACCATATCAAGTAAATAAAGAAATAATGGATAAAACTGGTAATCCAAA
TGTTATTTTTGAGCATTGCTTACCATCTTTCCATAATGCTGATACGAAAATAGGTCAACAAATTTTTGAAAAATATGGTA
TTCGAGAAATGGAAGTTACAGATGAAGTATTCGAAAGTAAAGCTTCAGTTGTATTCCAAGAAGCTGAGAACAGAATGCAT
ACAATCAAAGCAGTCATGGTTGCTACATTGGGTGAATTTTAA

Upstream 100 bases:

>100_bases
TTAATTATTGATAAAATATTACAAATTTTAATAGTAGGTTGTGTTTATTTTGTATGCGCTTACAATTTAGGTGTAACTAA
AATAAAAGGAGTTGTTATTA

Downstream 100 bases:

>100_bases
ATGATATAAGGAAGTGAATATGATGGCGAAAATAGTAGTAGCATTAGGTGGTAATGCTTTAGGAAAATCACCTCAAGAAC
AACTCGAGCTTGTTAAAAAT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPT
GSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTY
VGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPD
EVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMH
TIKAVMVATLGEF

Sequences:

>Translated_333_residues
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPT
GSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTY
VGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPD
EVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMH
TIKAVMVATLGEF
>Mature_333_residues
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPT
GSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTY
VGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPD
EVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMH
TIKAVMVATLGEF

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=331, Percent_Identity=36.8580060422961, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790703, Length=332, Percent_Identity=58.433734939759, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786469, Length=334, Percent_Identity=57.7844311377245, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI2367364, Length=335, Percent_Identity=26.2686567164179, Blast_Score=78, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=329, Percent_Identity=28.8753799392097, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322331, Length=228, Percent_Identity=27.1929824561404, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24642586, Length=342, Percent_Identity=22.8070175438596, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_STAAC (Q5HGR3)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186044.1
- ProteinModelPortal:   Q5HGR3
- SMR:   Q5HGR3
- STRING:   Q5HGR3
- EnsemblBacteria:   EBSTAT00000009012
- GeneID:   3238259
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1181
- TIGR:   SACOL1181
- eggNOG:   COG0078
- GeneTree:   EBGT00050000023906
- HOGENOM:   HBG579429
- OMA:   DFRIFAP
- ProtClustDB:   PRK04284
- BioCyc:   SAUR93062:SACOL1181-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 37517; Mature: 37517

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 107-107 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCE
CAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEY
EEEEEEECCCCCEEEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMG
CCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEC
MNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPD
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEEECCCHH
EVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVT
HHHHHHHHHHCCCCCCHHHHCCCCCCCEEHHHCCCCCCCCHHHHHHHHHHHHCCEEEHHH
DEVFESKASVVFQEAENRMHTIKAVMVATLGEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCE
CAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEY
EEEEEEECCCCCEEEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
SGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMG
CCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEC
MNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPD
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEEECCCHH
EVWKERLELLKPYQVNKEIMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVT
HHHHHHHHHHCCCCCCHHHHCCCCCCCEEHHHCCCCCCCCHHHHHHHHHHHHCCEEEHHH
DEVFESKASVVFQEAENRMHTIKAVMVATLGEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA