Click here to switch to the map view.

The map label for this gene is fabF

Identifier: 57650176

GI number: 57650176

Start: 995709

End: 996953

Strand: Direct

Name: fabF

Synonym: SACOL0988

Alternate gene names: 57650176

Gene position: 995709-996953 (Clockwise)

Preceding gene: 57650175

Following gene: 57650178

Centisome position: 35.44

GC content: 38.8

Gene sequence:

>1245_bases
ATGAGTCAAAATAAAAGAGTAGTTATTACAGGTATGGGAGCCCTTTCTCCAATCGGTAATGATGTCAAAACAACATGGGA
GAATGCTCTAAAAGGCGTAAATGGTATCGATAAAATTACACGTATCGATACTGAACCTTATAGCGTTCACTTAGCAGGAG
AACTTAAAAACTTTAATATTGAAGATCATATCGACAAAAAAGAAGCGCGTCGTATGGATAGATTTACTCAATATGCAATT
GTAGCAGCTAGAGAGGCTGTTAAAGATGCGCAATTAGATATCAATGAAAATACTGCAGATCGAATCGGTGTATGGATTGG
TTCTGGTATCGGTGGTATGGAAACATTTGAAATTGCACATAAACAATTAATGGATAAAGGCCCAAGACGTGTGAGTCCAT
TTTTCGTACCAATGTTAATTCCTGATATGGCAACTGGGCAAGTATCAATTGACTTAGGTGCAAAAGGACCAAATGGTGCA
ACAGTTACAGCATGTGCAACAGGTACAAATTCAATCGGAGAAGCATTTAAAATTGTGCAACGCGGTGATGCAGATGCAAT
GATTACTGGTGGTACAGAAGCACCAATTACTCATATGGCAATTGCTGGTTTCAGTGCAAGTCGAGCGCTTTCTACAAATG
ATGACATTGAAACAGCATGTCGTCCATTCCAAGAAGGTAGAGATGGTTTTGTTATGGGTGAAGGTGCTGGTATTTTAGTA
ATTGAATCTTTAGAATCAGCACAAGCTCGAGGTGCCAATATTTATGCTGAGATAGTTGGCTATGGTACTACAGGTGATGC
TTATCATATTACAGCGCCAGCTCCAGAAGGTGAAGGTGGTTCTAGAGCAATGCAAGCAGCTATGGATGATGCTGGTATTG
AACCTAAAGATGTACAATACTTAAATGCCCATGGTACAAGTACTCCTGTTGGTGACTTAAATGAAGTTAAAGCTATTAAA
AATACATTTGGTGAAGCAGCTAAACACTTAAAAGTTAGCTCAACAAAATCAATGACTGGTCACTTACTTGGTGCAACAGG
TGGAATTGAAGCAATCTTCTCAGCGCTTTCAATTAAAGACTCTAAAGTCGCACCGACAATTCATGCGGTAACACCAGATC
CAGAATGTGATTTGGATATTGTTCCAAATGAAGCGCAAGACCTTGATATTACTTATGCAATGAGTAATAGCTTAGGATTC
GGTGGACATAACGCAGTATTAGTATTCAAGAAATTTGAAGCATAA

Upstream 100 bases:

>100_bases
GTAAAATCAAAGATGATGATACAATTGTTCTTGTCGGATTCGGTGGCGGCCTAACTTGGGGCGCAATGACAATAAAATGG
GGAAAATAGGAGGATAACGA

Downstream 100 bases:

>100_bases
CTATAAAAATCTTCAGTAACGTTGTTTTAGTTACTGAAGATTTTTTCAGTTTCTTTATACTAAGATGAGCGACAGCACAA
TCGTCATAATAAAATATAAA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAI
VAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGA
TVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIK
NTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGF
GGHNAVLVFKKFEA

Sequences:

>Translated_414_residues
MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAI
VAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGA
TVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIK
NTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGF
GGHNAVLVFKKFEA
>Mature_413_residues
SQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIV
AAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGAT
VTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVI
ESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKN
TFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFG
GHNAVLVFKKFEA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=44.9519230769231, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI223972627, Length=170, Percent_Identity=46.4705882352941, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI41872631, Length=420, Percent_Identity=25.2380952380952, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=51.7073170731707, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=39.6634615384615, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.7314148681055, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=40.6976744186046, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=424, Percent_Identity=27.3584905660377, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=350, Percent_Identity=23.1428571428571, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=37.9464285714286, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=43.3333333333333, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI221330659, Length=425, Percent_Identity=25.1764705882353, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI19920632, Length=425, Percent_Identity=25.1764705882353, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24581345, Length=421, Percent_Identity=22.5653206650831, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABF_STAAC (Q5HHA1)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185856.1
- PDB:   2GQD
- PDBsum:   2GQD
- ProteinModelPortal:   Q5HHA1
- SMR:   Q5HHA1
- STRING:   Q5HHA1
- EnsemblBacteria:   EBSTAT00000008795
- GeneID:   3237606
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0988
- TIGR:   SACOL0988
- eggNOG:   COG0304
- GeneTree:   EBGT00050000024560
- HOGENOM:   HBG757733
- OMA:   NTAREMK
- ProtClustDB:   CLSK885050
- BioCyc:   SAUR93062:SACOL0988-MONOMER
- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR11712
- PIRSF:   PIRSF000447
- TIGRFAMs:   TIGR03150

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; SSF53901 Thiolase-like

EC number: =2.3.1.179

Molecular weight: Translated: 43740; Mature: 43609

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHEECCCCEEEEEEEECCCCCC
EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEEEECCCCCHHHHHHHH
KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
HHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
CCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCEEE
IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
EECCHHHHCCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
EECCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCHHHHHHHHHCCC
SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
CCCCCEEEEECCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
SQNKRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNI
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHEECCCCEEEEEEEECCCCCC
EDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEEEECCCCCHHHHHHHH
KQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ
HHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
RGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILV
CCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCEEE
IESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQY
EECCHHHHCCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEE
LNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKD
EECCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEECCCCHHHHHHHHHCCC
SKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFEA
CCCCCEEEEECCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA