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The map label for this gene is rnr [H]

Identifier: 57650122

GI number: 57650122

Start: 873006

End: 875378

Strand: Direct

Name: rnr [H]

Synonym: SACOL0846

Alternate gene names: 57650122

Gene position: 873006-875378 (Clockwise)

Preceding gene: 57650121

Following gene: 57650123

Centisome position: 31.07

GC content: 34.81

Gene sequence:

>2373_bases
ATGAATTTAAAGCAATCTATAGAAGAGATTATTAATCAACCTGAATATGAACCTATGTCAGTGTCAGATTTTCAAGATGC
ATTAGGTTTAAGCAGTGCCGACTCGTTTAGAGATTTAATTAAGGTGCTTGTGGAGTTAGAACAATCAGGATTAATCGAAC
GTACAAAAACAGACAGATACCAAAAAAAGCATAGTTATAGAGGTCAATCAAAATTGATAAAAGGAACGTTAAGTCAAAAT
AAAAAAGGCTTTGCATTCTTAAGACCTGAAGATGAGGATATGGAAGATATATTTATTCCCCCGACGAAAATTAATCGTGC
CTTGGATGGAGATACTGTTATTGTAGAAATCCATCAATCAAAAGGTGAACATAAAGGTAAAATCGAAGGGGAAGTTAAGT
CGATTGAGAAGCATTCTGTAACTCAAGTTGTTGGTACGTATAGTGAAGCTAGACATTTTGGCTTTGTTATTCCGGATGAT
AAACGTATTATGCAAGATATTTTCATTCCTAAAGGTCAAAGTTTAGGCGCAGTCGATGGTCATAAGGTACTTGTACAAAT
TACTAAGTATGCTGATGGTTCAGATAATCCAGAAGGACATATTTCTGCTATTTTAGGACATAAAAATGATCCTGGCGTAG
ATATTTTATCTATTATCTATCAACATGGCATAGAAATTGAATTTCCTGATGAAGTGTTACAAGAAGCTGAAGCAGTACCT
GATCATATTGAAAATACTGAAATTAAAGGCCGTCATGATTTACGTGATGAATTGACAATCACAATTGATGGTGCTGATGC
TAAAGACTTAGATGACGCAATTAGTGTTAAAAAGTTAGCGAACGGTAATACGCAATTAACTGTAAGTATTGCTGATGTCA
GCTATTATGTAACAGAAGGTTCTGCATTGGATAAAGAGGCATATGATAGAGCGACAAGTGTATATCTTGTTGACCGTGTA
ATTCCAATGATTCCACATCGATTAAGTAATGGTATTTGTTCATTGAATCCTAATGTTGATCGTTTAACTCTAAGCTGTCG
CATGGAAATCGATGCTAGTGGTCGCGTTGTTAAACATGAAATTTTTGATAGTGTTATACATTCTGATTATCGAATGACGT
ATGATGCGGTAAATCAGATTATTACTGAAAAGGATCCTAACATTCGCGAACAATATAATGAAATTACGCCTATGCTAGAT
TTAGCACAAGATTTATCTAATCGTTTGATTCAAATGAGAAAACGACGTGGTGAAATCGATTTTGATATTAGTGAAGCAAA
AGTATTAGTTAACGAAGACGGTATACCAACAGATGTTCAATTAAGACAACGTGGCGAGGGTGAACGTCTAATTGAATCAT
TTATGTTAATTGCAAATGAAACAGTTGCTGAACATTTTAGTAAGTTAGATGTACCTTTTATTTACCGAGTGCATGAGCAA
CCTAAATCAGATCGCTTAAGACAATTCTTTGATTTTATTACAAACTTTGGCATCATGATTAAGGGTACTGGCGAAGATAT
TCATCCAACAACACTTCAAAAGGTTCAAGAAGAAGTAGAAGGTCGACCTGAACAAATGGTCATTTCAACAATGATGTTGC
GTTCAATGCAACAAGCGCATTATGATGATGTGAACTTGGGACATTTTGGCTTATCAGCTGAATATTATACGCATTTTACA
TCACCAATTAGACGTTATCCTGATTTAACAGTTCATCGTTTAATCCGTAAGTATTTAATTGAGAAATCAATGGATAACAA
AGAAGTGAAGCGTTGGGAAGACAAATTGCCTGAGTTAGCTGAACATACTTCTAAACGTGAACGTCGTGCTATTGAGGCAG
AACGTGATACTGATGAATTGAAAAAAGCAGAATATATGATTCAACATATTGGTGATGAATTTGAAGGTATTGTCAGCTCA
GTAGCTAACTTCGGTATGTTCATTGAATTGCCAAATACGATAGAAGGTATGGTTCATATTGCGAATATGACTGATGATTA
TTACCGTTTTGAAGAGCGTCAAATGGCATTAATTGGTGAGCGTCAAGCTAAAGTATTTAGAATTGGTGACACAGTTAAGG
TTAAAGTGACGCATGTTGATGTAGATGAACGATTAATTGATTTTCAAATTGTAGGTATGCCTTTACCGAAAAATGATCGA
TCACAGCGCCCAGCGCGAGGTAAGACAATTCAAGCCAAAACGCGTGGTAAATCATTAGATAAATCAAAATCTGATGATAA
GGGTCGTAAGAAAAAAGGTAAGCAACGTAAAGGTAAAAACCAACGTAATAATGATAAATCAGGTAATAGTAAGCATAAGC
CATTTTATAAAGATAAAAGTGTGAAAAAGAAAGCACGTCGTAAGAAAAAATAA

Upstream 100 bases:

>100_bases
TAAAGAGAAAGAACAAGTATTTGAAGATATTTATCAATTTTTAGAGTCATTAGACTGGTCAGAATAAAAAGAGATTTTAA
CATTAGAAAGGAGGGGCATA

Downstream 100 bases:

>100_bases
GCAGCAATGAGGTGAGTATGAATGGCTAAGAAGAAATCACCAGGTACATTAGCGGAAAATCGTAAGGCAAGACATGATTA
TAATATTGAAGATACGATTG

Product: VacB/RNase II family exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSYRGQSKLIKGTLSQN
KKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDD
KRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVP
DHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEGSALDKEAYDRATSVYLVDRV
IPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLD
LAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQ
PKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFT
SPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSS
VANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDR
SQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK

Sequences:

>Translated_790_residues
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSYRGQSKLIKGTLSQN
KKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDD
KRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVP
DHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEGSALDKEAYDRATSVYLVDRV
IPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLD
LAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQ
PKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFT
SPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSS
VANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDR
SQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK
>Mature_790_residues
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSYRGQSKLIKGTLSQN
KKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDD
KRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVP
DHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEGSALDKEAYDRATSVYLVDRV
IPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLD
LAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQ
PKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFT
SPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSS
VANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDR
SQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=421, Percent_Identity=32.0665083135392, Blast_Score=206, Evalue=6e-53,
Organism=Homo sapiens, GI190014625, Length=631, Percent_Identity=28.6846275752773, Blast_Score=193, Evalue=7e-49,
Organism=Homo sapiens, GI190014623, Length=631, Percent_Identity=28.6846275752773, Blast_Score=193, Evalue=7e-49,
Organism=Homo sapiens, GI219521928, Length=670, Percent_Identity=26.2686567164179, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI19115966, Length=670, Percent_Identity=26.2686567164179, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI156105695, Length=217, Percent_Identity=30.4147465437788, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI156105693, Length=211, Percent_Identity=29.8578199052133, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI87082383, Length=648, Percent_Identity=37.037037037037, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1787542, Length=601, Percent_Identity=25.7903494176373, Blast_Score=163, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17553506, Length=435, Percent_Identity=31.7241379310345, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=627, Percent_Identity=26.6347687400319, Blast_Score=162, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=511, Percent_Identity=29.1585127201566, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=410, Percent_Identity=23.1707317073171, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323943, Length=368, Percent_Identity=24.1847826086957, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24649634, Length=659, Percent_Identity=28.8315629742033, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24654592, Length=424, Percent_Identity=29.7169811320755, Blast_Score=166, Evalue=8e-41,
Organism=Drosophila melanogaster, GI19922976, Length=424, Percent_Identity=29.7169811320755, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24654597, Length=424, Percent_Identity=29.7169811320755, Blast_Score=165, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 90437; Mature: 90437

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRY
CCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QKKHSYRGQSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQS
HHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCHHHHHCCCCCEEEEEEECC
KGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCC
HKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVP
CEEEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEECCHHHHHHHHHCC
DHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEG
HHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEECC
SALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCCHHHH
IFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLDLAQDLSNRLIQMRKRRGEID
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQ
EECCCCEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAH
CCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
YDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSSVANFGMFIELPNTIEGMVHI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEE
ANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDR
ECCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEECCCHHEEEEEEEECCCCCCCC
SQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKS
CCCCCCCCEEEEHHCCCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCCCHH
VKKKARRKKK
HHHHHHHCCC
>Mature Secondary Structure
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRY
CCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QKKHSYRGQSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQS
HHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCHHHHHCCCCCEEEEEEECC
KGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCC
HKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVP
CEEEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEECCHHHHHHHHHCC
DHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEG
HHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEECC
SALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCCHHHH
IFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLDLAQDLSNRLIQMRKRRGEID
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQ
EECCCCEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAH
CCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
YDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSSVANFGMFIELPNTIEGMVHI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEE
ANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDR
ECCCHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEEEEECCCHHEEEEEEEECCCCCCCC
SQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKS
CCCCCCCCEEEEHHCCCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCCCHH
VKKKARRKKK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]