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The map label for this gene is hlb [H]

Identifier: 57634641

GI number: 57634641

Start: 2082904

End: 2083143

Strand: Direct

Name: hlb [H]

Synonym: SAV1939

Alternate gene names: 57634641

Gene position: 2082904-2083143 (Clockwise)

Preceding gene: 15924926

Following gene: 15924930

Centisome position: 72.36

GC content: 30.42

Gene sequence:

>240_bases
TTGCATCTATTTTGTTGTAAGCTATATAAAAGGAGTGATAATGATGGTAAAAAAACAAAATCCAATTCACTAAAAAAAGT
TGCAACACTTGCATTAGCAAATTTATTATTAGTTGGTGCACTTACTGACAATAGTGCCAAAGCCGAATCTAAGAAAGATG
ATACTGATTTGAAGTTAGTTAGTCATAACGTTTATATGTTATCGACCGTTTTGTATCCAAACTGGAGACTTTTAACATAA

Upstream 100 bases:

>100_bases
ATATTTGTCGATTATATTTACAGCATCTTTATACTCAAAAAACATTTACTTAAAAATATAAATTCGATTTAATAATTAAT
TTAAATTTAGTTAATCAATT

Downstream 100 bases:

>100_bases
AATTACTTATCATTCAAAAAGTAAAACAGCATAATATCAAGGTTTATAACTTTATCATTATCAATAATACCTCATATAAA
ATAAAATTTTAGGGACTTTT

Product: truncated beta-hemolysin

Products: NA

Alternate protein names: Beta-hemolysin; Beta-toxin; Sphingomyelinase; SMase [H]

Number of amino acids: Translated: 79; Mature: 79

Protein sequence:

>79_residues
MHLFCCKLYKRSDNDGKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Sequences:

>Translated_79_residues
MHLFCCKLYKRSDNDGKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT
>Mature_79_residues
MHLFCCKLYKRSDNDGKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 8857; Mature: 8857

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLFCCKLYKRSDNDGKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLV
CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEE
SHNVYMLSTVLYPNWRLLT
CCCEEEEEEEECCCEEEEC
>Mature Secondary Structure
MHLFCCKLYKRSDNDGKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLV
CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEE
SHNVYMLSTVLYPNWRLLT
CCCEEEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8914839 [H]