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The map label for this gene is adhc1 [H]

Identifier: 57238565

GI number: 57238565

Start: 1616954

End: 1618030

Strand: Reverse

Name: adhc1 [H]

Synonym: CJE1719

Alternate gene names: 57238565

Gene position: 1618030-1616954 (Counterclockwise)

Preceding gene: 57238569

Following gene: 57238563

Centisome position: 91.01

GC content: 39.65

Gene sequence:

>1077_bases
ATGCAATACAAAATTTTAGAAAACAATCGCATCGCAAGTAAAGGCTATGCAATGCTTAGCAAGGATGCGAAATTTACACC
CTTTGAATTTAGTCGCCATGCTATTGGCGATAATGATATTTTGATTAAAATCCTATATGCAGGCATTTGTCATAGCGATA
TTCACACCGCAAGAAGCGAGTGGGGAGAAGCTACTTATCCTTGCGTGCCTGGGCATGAGATAGCAGGAGAAGTTATCGCT
GTGGGTAAAAATGTGAGTAAATTTAAAGTAGGAGATTACGCAGGGGTTGGTTGTATGGTAAATTCATGCGGTGAGTGCGA
TGCTTGCAAACGCTCACAAGAGCAGTTTTGCGAAAATGGCAAAACCATCTTTACTTACAATAGTTGTGATGTATTTCATG
GCAATGAAAACACTTATGGGGGCTACTCAAACAACATAGTTGTAAGTGAAAAATTTGCCGTTTGTGTGCCAAAAGATGCA
CCGATGGAAAAAGTCGCGCCTTTGCTTTGTGCAGGAATTACCACTTATTCTCCGCTTAAATTTTCAAATATCAAAGAAGG
CTCAAGCGTAGCAGTAGCGGGATTTGGCGGACTTGGTATGATGGCGGTTAAATATGCTGTTAAAATGGGTGCAAAGGTTA
GCGTTTTTGCTAGAAATGAAAACAAAAAAGCCGATGCTTTGGCTATGGGCGTGAGTTCTTTTTATACAAGCACAGATAAA
AATGCTGTAAAAGAACGCTTTGATCTTATCATCTCTACCATCCCAACTCCTTATGATCCTAGTACTTATATGGATTTGCT
TAAATTTGGCGGTGAAATGGCGATAGTGGGTTTGCCACCTCACGAAGTTGCTCCAAGTATCAGCGTGATAACCTTTGTAC
ATAAAGCGGGTAAAAAAGTCTATGGTTCGCTAATCGGCGGGATCGCAGAAACTCAAGAAATGCTTGATTTTTCTTTAAAA
CATGAAATTTATCCAGAAACCGAGCTTATCACCCCACAAGAAATCGATAAAGCTTATGAAAATCTAACCTCAGGAAAGGC
TAAATTTCGCTATGTCATTGATATGACAAAAGAATAA

Upstream 100 bases:

>100_bases
AATTATAGCATTTATACTAATTTTTAAAAAATTATTTTCACTCTTGACTTATAGCTACTCTAATGTTTTATAATTATAAA
AAATCAAAAAAGGAGCAAAA

Downstream 100 bases:

>100_bases
TTTAATACTTATCAAAAACCACATCGCTAATGTCAAATCCCCTTTTTGCTTAGCGATGTTTAAAAGCTCTTTTATATTTT
TTTCATCTATTATATTTCTT

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQYKILENNRIASKGYAMLSKDAKFTPFEFSRHAIGDNDILIKILYAGICHSDIHTARSEWGEATYPCVPGHEIAGEVIA
VGKNVSKFKVGDYAGVGCMVNSCGECDACKRSQEQFCENGKTIFTYNSCDVFHGNENTYGGYSNNIVVSEKFAVCVPKDA
PMEKVAPLLCAGITTYSPLKFSNIKEGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGVSSFYTSTDK
NAVKERFDLIISTIPTPYDPSTYMDLLKFGGEMAIVGLPPHEVAPSISVITFVHKAGKKVYGSLIGGIAETQEMLDFSLK
HEIYPETELITPQEIDKAYENLTSGKAKFRYVIDMTKE

Sequences:

>Translated_358_residues
MQYKILENNRIASKGYAMLSKDAKFTPFEFSRHAIGDNDILIKILYAGICHSDIHTARSEWGEATYPCVPGHEIAGEVIA
VGKNVSKFKVGDYAGVGCMVNSCGECDACKRSQEQFCENGKTIFTYNSCDVFHGNENTYGGYSNNIVVSEKFAVCVPKDA
PMEKVAPLLCAGITTYSPLKFSNIKEGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGVSSFYTSTDK
NAVKERFDLIISTIPTPYDPSTYMDLLKFGGEMAIVGLPPHEVAPSISVITFVHKAGKKVYGSLIGGIAETQEMLDFSLK
HEIYPETELITPQEIDKAYENLTSGKAKFRYVIDMTKE
>Mature_358_residues
MQYKILENNRIASKGYAMLSKDAKFTPFEFSRHAIGDNDILIKILYAGICHSDIHTARSEWGEATYPCVPGHEIAGEVIA
VGKNVSKFKVGDYAGVGCMVNSCGECDACKRSQEQFCENGKTIFTYNSCDVFHGNENTYGGYSNNIVVSEKFAVCVPKDA
PMEKVAPLLCAGITTYSPLKFSNIKEGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGVSSFYTSTDK
NAVKERFDLIISTIPTPYDPSTYMDLLKFGGEMAIVGLPPHEVAPSISVITFVHKAGKKVYGSLIGGIAETQEMLDFSLK
HEIYPETELITPQEIDKAYENLTSGKAKFRYVIDMTKE

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.8221574344023, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=26.8221574344023, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=25.6983240223464, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=391, Percent_Identity=24.8081841432225, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=384, Percent_Identity=25, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI34577061, Length=357, Percent_Identity=25.2100840336134, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=24.7910863509749, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI71565154, Length=222, Percent_Identity=29.2792792792793, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI71565152, Length=226, Percent_Identity=28.7610619469027, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=41.9540229885057, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=32.9479768786127, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI87081918, Length=345, Percent_Identity=27.8260869565217, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790045, Length=281, Percent_Identity=28.1138790035587, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=165, Percent_Identity=32.1212121212121, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788073, Length=266, Percent_Identity=26.6917293233083, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=194, Percent_Identity=31.9587628865979, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082125, Length=186, Percent_Identity=29.5698924731183, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788407, Length=253, Percent_Identity=26.8774703557312, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=27.5964391691395, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=26.969696969697, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=332, Percent_Identity=28.0120481927711, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=188, Percent_Identity=33.5106382978723, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=183, Percent_Identity=34.9726775956284, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=186, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=343, Percent_Identity=33.5276967930029, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319949, Length=344, Percent_Identity=29.3604651162791, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=31.3253012048193, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=29.5321637426901, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323961, Length=331, Percent_Identity=29.607250755287, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=28.6549707602339, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=27.445652173913, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=228, Percent_Identity=30.2631578947368, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737895, Length=350, Percent_Identity=25.4285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137530, Length=180, Percent_Identity=29.4444444444444, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737897, Length=180, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 39055; Mature: 39055

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYKILENNRIASKGYAMLSKDAKFTPFEFSRHAIGDNDILIKILYAGICHSDIHTARSE
CCEEEECCCCCCCCCCCEECCCCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
WGEATYPCVPGHEIAGEVIAVGKNVSKFKVGDYAGVGCMVNSCGECDACKRSQEQFCENG
CCCCCCCCCCCHHHCCCEEEECCCCCEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCC
KTIFTYNSCDVFHGNENTYGGYSNNIVVSEKFAVCVPKDAPMEKVAPLLCAGITTYSPLK
CEEEEECCEEEEECCCCCCCCCCCCEEEECCEEEEECCCCCHHHHHHHHHHCCCCCCCCC
FSNIKEGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGVSSFYTSTDK
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCH
NAVKERFDLIISTIPTPYDPSTYMDLLKFGGEMAIVGLPPHEVAPSISVITFVHKAGKKV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHH
YGSLIGGIAETQEMLDFSLKHEIYPETELITPQEIDKAYENLTSGKAKFRYVIDMTKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCC
>Mature Secondary Structure
MQYKILENNRIASKGYAMLSKDAKFTPFEFSRHAIGDNDILIKILYAGICHSDIHTARSE
CCEEEECCCCCCCCCCCEECCCCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
WGEATYPCVPGHEIAGEVIAVGKNVSKFKVGDYAGVGCMVNSCGECDACKRSQEQFCENG
CCCCCCCCCCCHHHCCCEEEECCCCCEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCC
KTIFTYNSCDVFHGNENTYGGYSNNIVVSEKFAVCVPKDAPMEKVAPLLCAGITTYSPLK
CEEEEECCEEEEECCCCCCCCCCCCEEEECCEEEEECCCCCHHHHHHHHHHCCCCCCCCC
FSNIKEGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGVSSFYTSTDK
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCH
NAVKERFDLIISTIPTPYDPSTYMDLLKFGGEMAIVGLPPHEVAPSISVITFVHKAGKKV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHH
YGSLIGGIAETQEMLDFSLKHEIYPETELITPQEIDKAYENLTSGKAKFRYVIDMTKE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]