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The map label for this gene is purM [H]

Identifier: 57238547

GI number: 57238547

Start: 1600373

End: 1601362

Strand: Reverse

Name: purM [H]

Synonym: CJE1700

Alternate gene names: 57238547

Gene position: 1601362-1600373 (Counterclockwise)

Preceding gene: 57238551

Following gene: 57238545

Centisome position: 90.07

GC content: 34.75

Gene sequence:

>990_bases
ATGAAAATTTCATATGAAGATGCAGGCGTAAGTATAGATAATGGAAATGCCTTTGTAGAGGCTATAAAACCTTTGGTTAA
AGAAACTTTTAATGATAATGTTGTAGGCGGAATTGGTTCTTTTGCTGGTGCTTTTAGAATGCCAAGCGGTTTTAAAAAGC
CTGTGATTTTAGGTGCAACAGATGGAGTTGGTACCAAGCTTCGCTTGGCAATTGATGCTAAAAAATATGATACTATAGGA
CAAGATTTAGTAGCAATGTGCGTGAATGATTTGATTTGTAATTTTGCTACGCCTTTGTTTTTTCTAGATTATTATGCTAC
AGCTAAACTTGAAGTAGAAGTAGCAAAGGCTGTTGTATCAGGCATTGCCAAGGGATGTAAGATGGCAAATTGTGCATTAA
TCGGCGGAGAAACTGCTGAAATGCCTGGAATGTATGCAAAAGATGATTTTGATCTTGCGGGTTTTGCAGTGGGTATGGCT
GAAGAAGATGAGATCGATAGAAGTAAATTTGTTAAAAATGGTGATATTTTATTGGCACTTCCTAGTTCAGGACTTCATTC
AAATGGTTATTCTTTAGCTAGAAAAGTACTTTTTGAAAGTTTAAAATTAAAATTTGATGACAAGATAGAGGATAAAAATT
TAATTGATATTTTATTAGAGCCTACAAGGATTTATGTGCGTGATTTTCTTACATTAAAGCCTTATATTAGTGCTCTAGCT
CATATTACAGGGGGTGGTTTAGTAGAAAATTTACCACGCGTTTTGCCTCGTGGCATGGGTGCAACTATACGCAAACACCA
TCTTAAAACTCCTGAAATTTTTTATATTATAGGACAGGCTGTAGAAGAAAGCGAAATGTATAGAAGCTTTAACATGGGAG
TGGGTTTAGTAATGGTTGTAGATCCTTCTAATGTAAGTAAGGTTTTAGAAAATTCAGATGCCTTTATTATCGGCGAAATT
TGCATTAATGAAGGTATTGTTTTAGAATGA

Upstream 100 bases:

>100_bases
CACAAGCAATTGAAGCGGTTACAAAAAAAGCATTTTTCATCTTATGCCTTATTAAAACTTTTTTCGTTAAAATACCTTTT
TAGTTCTTAAAGGAAAATAA

Downstream 100 bases:

>100_bases
AAATAAAGCGTCATACGCTTTATTTTTTTATTTTAAGTTCTATTTTTGTAGTGTTTTGTTCTTTTGGCAAAGGATTGGTT
TGTGCTAGATAAAAGGCTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKISYEDAGVSIDNGNAFVEAIKPLVKETFNDNVVGGIGSFAGAFRMPSGFKKPVILGATDGVGTKLRLAIDAKKYDTIG
QDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVSGIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMA
EEDEIDRSKFVKNGDILLALPSSGLHSNGYSLARKVLFESLKLKFDDKIEDKNLIDILLEPTRIYVRDFLTLKPYISALA
HITGGGLVENLPRVLPRGMGATIRKHHLKTPEIFYIIGQAVEESEMYRSFNMGVGLVMVVDPSNVSKVLENSDAFIIGEI
CINEGIVLE

Sequences:

>Translated_329_residues
MKISYEDAGVSIDNGNAFVEAIKPLVKETFNDNVVGGIGSFAGAFRMPSGFKKPVILGATDGVGTKLRLAIDAKKYDTIG
QDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVSGIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMA
EEDEIDRSKFVKNGDILLALPSSGLHSNGYSLARKVLFESLKLKFDDKIEDKNLIDILLEPTRIYVRDFLTLKPYISALA
HITGGGLVENLPRVLPRGMGATIRKHHLKTPEIFYIIGQAVEESEMYRSFNMGVGLVMVVDPSNVSKVLENSDAFIIGEI
CINEGIVLE
>Mature_329_residues
MKISYEDAGVSIDNGNAFVEAIKPLVKETFNDNVVGGIGSFAGAFRMPSGFKKPVILGATDGVGTKLRLAIDAKKYDTIG
QDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVSGIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMA
EEDEIDRSKFVKNGDILLALPSSGLHSNGYSLARKVLFESLKLKFDDKIEDKNLIDILLEPTRIYVRDFLTLKPYISALA
HITGGGLVENLPRVLPRGMGATIRKHHLKTPEIFYIIGQAVEESEMYRSFNMGVGLVMVVDPSNVSKVLENSDAFIIGEI
CINEGIVLE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=45.6456456456456, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=45.6456456456456, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=45.6456456456456, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI1788845, Length=312, Percent_Identity=53.2051282051282, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17567511, Length=319, Percent_Identity=42.6332288401254, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321203, Length=321, Percent_Identity=45.1713395638629, Blast_Score=264, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24582400, Length=288, Percent_Identity=41.6666666666667, Blast_Score=218, Evalue=6e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35680; Mature: 35680

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISYEDAGVSIDNGNAFVEAIKPLVKETFNDNVVGGIGSFAGAFRMPSGFKKPVILGAT
CCCEECCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEECC
DGVGTKLRLAIDAKKYDTIGQDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVS
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHH
GIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMAEEDEIDRSKFVKNGDILLAL
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCEEEEE
PSSGLHSNGYSLARKVLFESLKLKFDDKIEDKNLIDILLEPTRIYVRDFLTLKPYISALA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
HITGGGLVENLPRVLPRGMGATIRKHHLKTPEIFYIIGQAVEESEMYRSFNMGVGLVMVV
HHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEE
DPSNVSKVLENSDAFIIGEICINEGIVLE
CCCHHHHHHCCCCCEEEEEEECCCCEEEC
>Mature Secondary Structure
MKISYEDAGVSIDNGNAFVEAIKPLVKETFNDNVVGGIGSFAGAFRMPSGFKKPVILGAT
CCCEECCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEECC
DGVGTKLRLAIDAKKYDTIGQDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVS
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHH
GIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMAEEDEIDRSKFVKNGDILLAL
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHCCCCCEEEEE
PSSGLHSNGYSLARKVLFESLKLKFDDKIEDKNLIDILLEPTRIYVRDFLTLKPYISALA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
HITGGGLVENLPRVLPRGMGATIRKHHLKTPEIFYIIGQAVEESEMYRSFNMGVGLVMVV
HHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEE
DPSNVSKVLENSDAFIIGEICINEGIVLE
CCCHHHHHHCCCCCEEEEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA