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The map label for this gene is moeA [H]

Identifier: 57238543

GI number: 57238543

Start: 1592793

End: 1593983

Strand: Direct

Name: moeA [H]

Synonym: CJE1693

Alternate gene names: 57238543

Gene position: 1592793-1593983 (Clockwise)

Preceding gene: 57238542

Following gene: 57238546

Centisome position: 89.59

GC content: 35.18

Gene sequence:

>1191_bases
ATGCTAATGTCTTATGAAGAAAGTTTAAAAATTTTACACTCTCATATCAAAACCTATGAAAAGATTGAAAAAATAGCTCT
TACAGAGTGTTTAGGACGCATTTTAGCTCAAGACATAAAAGCCCCTAAAAATCAGCCTGAATTTCCAACCTCGGCTATGG
ATGGTTATGCGATCAAATTTGAAGATCAAGACAAGCCTTTAAAAATTTTAGGCCTCACACCTGCGGGCACTATGCCACAA
TTTAGCGTACAAAATGGCACTTGTGTAAAAACCTTTACAGGCTCACTCATGAGCGAAGGAAGCGATACTTTAGTCCCTGT
TGAAAATATACGCATAGAAAATGATACTCTTTTTATAGAAAAAAAAGTTCCCCAAGCTTTTGCCGTGCGTGCGGTAGGAG
AAAACTATAAAAAAGATGAAATTTTACTCAAAAAAGGCACAAAGTTAAATTATAGCGAGATAGCTCTTTTAGCTGAACTT
GGATTTTTTCACATTAGTGTGTTTATAAAGCCTATTGTAGGGGTTTTAAGTAGTGGAAGTGAGATCAAAGATCTAGGAGA
AGCCTTGGAAAATCCTGCTCAAATCCGCTCTTCAAATCATATCGCCATAGCTAATTTAGCTAAAAATTTAAATTGCGATA
CAAGGGTTTTTCCTCTTTTAAAAGATGATGAGAAAGCCACTTTTTCCACCCTTGAAAGTGCTTTGCAAAGTTGTGATATT
TTGGTTACAACGGGCGGGGTTTCTATGGGAGATTTTGACTTTTTAAAAAAAGCCATCAAAGAATACGAAATCATCATCGA
TAAAGCCGACATAAAACCAGGTAGACATATCAAAATAGCTAAGGCTAATGAAAAATTCATCATCGCCTTACCAGGTTTTC
CTTACTCGGCTATGGTAATGTTTAATCTTTACGCAAGAGAGATTTTAAACTCTTGGTTACTTCAGCCTAAAGACTATATT
TGCAAAGCCTTTTTACAAGGAAGTTACAAGAAAAAAACACCTTATTTGGAATTTGTCGCTTGTAACATAAAGTTTGAAAA
TGGACGCATTTTAGCCAATCTTGAAGGCAAAAAAGAAGGCTCTAGTGCGATTATAAACAATCTTAACAATAAAGCTGCCC
TTATGGTGGCGCCAAAAGAATGTGAAATTTTAGAAAATGAAAGTTTAGTGGATATTATCTTTATGCCTTAA

Upstream 100 bases:

>100_bases
AATTTTTTAAAAATTCAAGTCTCCAAAGAAAATTTGACACAGATTTTGAATTTTATACAACAAACAAGACTCAAATTTAT
ATCAGTATGAAGGAATAAAG

Downstream 100 bases:

>100_bases
AATTATTTAAATAATTTTATTTCGATTTTAATCAACCCTAAATTTCAATAAGTTTCAAATTCGCAACCTCCTTTTAGTGG
AGTAATTAGCCCTAGCGGAG

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKAPKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLVPVENIRIENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTKLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LVTTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVAPKECEILENESLVDIIFMP

Sequences:

>Translated_396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKAPKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLVPVENIRIENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTKLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LVTTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVAPKECEILENESLVDIIFMP
>Mature_396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKAPKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLVPVENIRIENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTKLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LVTTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVAPKECEILENESLVDIIFMP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=29.1139240506329, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=29.1139240506329, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1787049, Length=367, Percent_Identity=28.6103542234332, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=293, Percent_Identity=29.3515358361775, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=153, Percent_Identity=36.6013071895425, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136978, Length=317, Percent_Identity=28.0757097791798, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24638841, Length=317, Percent_Identity=28.0757097791798, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44059; Mature: 44059

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKAPKNQPEFPTSAMDGYAIKF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
EDQDKPLKILGLTPAGTMPQFSVQNGTCVKTFTGSLMSEGSDTLVPVENIRIENDTLFIE
CCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHCCCCCCEEEHHHEEEECCEEEEE
KKVPQAFAVRAVGENYKKDEILLKKGTKLNYSEIALLAELGFFHISVFIKPIVGVLSSGS
ECCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
HHHHHHHHHCCCHHHCCCCCEEEEEHHHCCCCCCEEECEEECCCHHHHHHHHHHHHCCCE
LVTTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVM
EEEECCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
FNLYAREILNSWLLQPKDYICKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCC
SSAIINNLNNKAALMVAPKECEILENESLVDIIFMP
CHHHHHCCCCCEEEEECCCCCCEECCCCEEEEEECC
>Mature Secondary Structure
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKAPKNQPEFPTSAMDGYAIKF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
EDQDKPLKILGLTPAGTMPQFSVQNGTCVKTFTGSLMSEGSDTLVPVENIRIENDTLFIE
CCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHCCCCCCEEEHHHEEEECCEEEEE
KKVPQAFAVRAVGENYKKDEILLKKGTKLNYSEIALLAELGFFHISVFIKPIVGVLSSGS
ECCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
HHHHHHHHHCCCHHHCCCCCEEEEEHHHCCCCCCEEECEEECCCHHHHHHHHHHHHCCCE
LVTTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVM
EEEECCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
FNLYAREILNSWLLQPKDYICKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCC
SSAIINNLNNKAALMVAPKECEILENESLVDIIFMP
CHHHHHCCCCCEEEEECCCCCCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]