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The map label for this gene is mco [H]

Identifier: 57238539

GI number: 57238539

Start: 1590169

End: 1591710

Strand: Direct

Name: mco [H]

Synonym: CJE1689

Alternate gene names: 57238539

Gene position: 1590169-1591710 (Clockwise)

Preceding gene: 57238524

Following gene: 57238540

Centisome position: 89.44

GC content: 32.88

Gene sequence:

>1542_bases
ATGAATAGAAGAAATTTTTTAAAATTTAATGCACTTACTCTAGCAAGTATGGGTGTAGCCTATGCAAATCCTATGCACGA
TATGCACTCCATGCATAAAAATCATTCTATAAATCATGACTTAGATACTTCTTTTATAAACTTTGCTCCAAAAAATTTAA
AGCTTTTAGATCCAAAACAATTCCCCCAAGGAGAAATTTTAAAAGCCTTGCCTTTACTCAAAAATGAAAGTAAAGAAAAA
AATATTTTTCGTGCTACCCTAGAAATCAAAGAAAATCATATAGAGCTTATCAAAGGTAAAAAAACCTTATTTTATACTTA
CAATGGCCTCGTGCCTGCTCCAAAAATAGAAGTTTTTGAAGGAGATAAACTTGAAATTTTAGTCAAAAACAAACTCAAAG
AAGCTACAACTATACATTGGCATGGCGTTCCTGTGCCACCTGATCAAGATGGAAGCCCACATGATCCTATCTTAGCAGGA
GAAGAAAGAATATATCGTTTTGAAATTCCTCAAGATAGCGCAGGAACTTACTGGTATCATCCACATCCTCATTATACGGC
TTCTAAACAAGTTTTTATGGGTTTAGCAGGGGCTTTTGTGATCAAAGCAAAAAAAGATGCTTTAAGTCATTTAAAAGAAA
AAGATTTGATGATTAGCGATTTGCGTCTTGATGAAAACGCTCAAATTCCAAACAACAACCTAAATGATTGGCTTAATGGT
AGAGAAGGAGAATTTGTACTCATCAATGGACAATTCAAACCTAAAATCAAACTCGCCACAAACGAACGCATACGCATTTA
TAATGCTACTGCAGCAAGATATTTAAATTTACGTATACAAGGAGCTAAGTTTATACTTGTTGGTACTGATGGTGGACTTA
TAGAAAAAGCTATTTATAAAGAAGAACTTTTCTTAAGTCCTGCTTCTCGTGTAGAAGTTTTAATCGACGCTCCAAAAGAT
GGGGAATTTAGACTAGAAAGTGCTTATTATGATAGGGATAAAATGATGGTAGAAGAAGAACCTAATACCCTATTTTTAGC
TAGTATTAGCCTAAAAAAAGAAAAATTAGAACTTCCAAAAAATTTAAAAATTTTCAAACCTTTAGAAGAACCTAAGGAAT
TTAAAGAAATAATCATGAGTGAAGATCATATGCAAATGCATGGAATGATGGGAAAAAGTGAAAATGAATTAAAAATCGCT
CTTGCGTCTATGTTTTTAATCAATGGCAAAAGCTATGATTTAAAACGCATTGATTTAAGCTCCAAGCTTGGAGTAGTTGA
AGACTGGATAGTGATAAATAAATCTCACATGGATCATCCTTTCCACATACACGGCACGCAATTTGAACTCATCTCATCAA
AACTCAATGGCAAAGTTCAAAAAGCCGAATTTAGAGCCTTCAGAGATACTATAAATGTGCGTCCTAATGAAGAGTTAAGA
CTTAGAATGAAACAAGATTTTAAAGGACTTAGAATGTATCATTGCCATATTTTAGAACATGAAGATTTAGGAATGATGGG
AAATTTAGAAGTAAAGGAATAA

Upstream 100 bases:

>100_bases
AAAATCATAACAAAATTAAACCAAATTTTCAAAATAAATATTTACTAAAACTAAAAAAATAATGACTATAATATAAAAAA
TCAAGCAAAAGGAAAAACTA

Downstream 100 bases:

>100_bases
AATGGTAAAAGTGGAATTTTTAGGCCCTATAAATAAAGAAAATTTAGAACTTGAAGTAAAAAATTTAAAAGAATTAAAAG
AAATTTTGCAAAAAGATGAG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MNRRNFLKFNALTLASMGVAYANPMHDMHSMHKNHSINHDLDTSFINFAPKNLKLLDPKQFPQGEILKALPLLKNESKEK
NIFRATLEIKENHIELIKGKKTLFYTYNGLVPAPKIEVFEGDKLEILVKNKLKEATTIHWHGVPVPPDQDGSPHDPILAG
EERIYRFEIPQDSAGTYWYHPHPHYTASKQVFMGLAGAFVIKAKKDALSHLKEKDLMISDLRLDENAQIPNNNLNDWLNG
REGEFVLINGQFKPKIKLATNERIRIYNATAARYLNLRIQGAKFILVGTDGGLIEKAIYKEELFLSPASRVEVLIDAPKD
GEFRLESAYYDRDKMMVEEEPNTLFLASISLKKEKLELPKNLKIFKPLEEPKEFKEIIMSEDHMQMHGMMGKSENELKIA
LASMFLINGKSYDLKRIDLSSKLGVVEDWIVINKSHMDHPFHIHGTQFELISSKLNGKVQKAEFRAFRDTINVRPNEELR
LRMKQDFKGLRMYHCHILEHEDLGMMGNLEVKE

Sequences:

>Translated_513_residues
MNRRNFLKFNALTLASMGVAYANPMHDMHSMHKNHSINHDLDTSFINFAPKNLKLLDPKQFPQGEILKALPLLKNESKEK
NIFRATLEIKENHIELIKGKKTLFYTYNGLVPAPKIEVFEGDKLEILVKNKLKEATTIHWHGVPVPPDQDGSPHDPILAG
EERIYRFEIPQDSAGTYWYHPHPHYTASKQVFMGLAGAFVIKAKKDALSHLKEKDLMISDLRLDENAQIPNNNLNDWLNG
REGEFVLINGQFKPKIKLATNERIRIYNATAARYLNLRIQGAKFILVGTDGGLIEKAIYKEELFLSPASRVEVLIDAPKD
GEFRLESAYYDRDKMMVEEEPNTLFLASISLKKEKLELPKNLKIFKPLEEPKEFKEIIMSEDHMQMHGMMGKSENELKIA
LASMFLINGKSYDLKRIDLSSKLGVVEDWIVINKSHMDHPFHIHGTQFELISSKLNGKVQKAEFRAFRDTINVRPNEELR
LRMKQDFKGLRMYHCHILEHEDLGMMGNLEVKE
>Mature_513_residues
MNRRNFLKFNALTLASMGVAYANPMHDMHSMHKNHSINHDLDTSFINFAPKNLKLLDPKQFPQGEILKALPLLKNESKEK
NIFRATLEIKENHIELIKGKKTLFYTYNGLVPAPKIEVFEGDKLEILVKNKLKEATTIHWHGVPVPPDQDGSPHDPILAG
EERIYRFEIPQDSAGTYWYHPHPHYTASKQVFMGLAGAFVIKAKKDALSHLKEKDLMISDLRLDENAQIPNNNLNDWLNG
REGEFVLINGQFKPKIKLATNERIRIYNATAARYLNLRIQGAKFILVGTDGGLIEKAIYKEELFLSPASRVEVLIDAPKD
GEFRLESAYYDRDKMMVEEEPNTLFLASISLKKEKLELPKNLKIFKPLEEPKEFKEIIMSEDHMQMHGMMGKSENELKIA
LASMFLINGKSYDLKRIDLSSKLGVVEDWIVINKSHMDHPFHIHGTQFELISSKLNGKVQKAEFRAFRDTINVRPNEELR
LRMKQDFKGLRMYHCHILEHEDLGMMGNLEVKE

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=552, Percent_Identity=27.3550724637681, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789394, Length=465, Percent_Identity=25.3763440860215, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321067, Length=480, Percent_Identity=22.7083333333333, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650186, Length=307, Percent_Identity=27.3615635179153, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18859919, Length=232, Percent_Identity=30.1724137931034, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574104, Length=159, Percent_Identity=32.0754716981132, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330000, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585842, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221329998, Length=227, Percent_Identity=30.8370044052863, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281360167, Length=227, Percent_Identity=30.8370044052863, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 59105; Mature: 59105

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRNFLKFNALTLASMGVAYANPMHDMHSMHKNHSINHDLDTSFINFAPKNLKLLDPKQ
CCCCCEEEEEEEEHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCEEECCCC
FPQGEILKALPLLKNESKEKNIFRATLEIKENHIELIKGKKTLFYTYNGLVPAPKIEVFE
CCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCEEEEEECCEEEEEEECCCCCCCEEEEEC
GDKLEILVKNKLKEATTIHWHGVPVPPDQDGSPHDPILAGEERIYRFEIPQDSAGTYWYH
CCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCEEEEC
PHPHYTASKQVFMGLAGAFVIKAKKDALSHLKEKDLMISDLRLDENAQIPNNNLNDWLNG
CCCCCCCCHHHHHHCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHCCC
REGEFVLINGQFKPKIKLATNERIRIYNATAARYLNLRIQGAKFILVGTDGGLIEKAIYK
CCCCEEEECCCCCCEEEEECCCEEEEEECCEEEEEEEEEECEEEEEEECCCCHHHHHHHH
EELFLSPASRVEVLIDAPKDGEFRLESAYYDRDKMMVEEEPNTLFLASISLKKEKLELPK
HHHHCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEECCCCEEEEEEEECCHHHHCCCC
NLKIFKPLEEPKEFKEIIMSEDHMQMHGMMGKSENELKIALASMFLINGKSYDLKRIDLS
CCEEECCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCEEEEECC
SKLGVVEDWIVINKSHMDHPFHIHGTQFELISSKLNGKVQKAEFRAFRDTINVRPNEELR
CCCCCEEEEEEEECCCCCCCEEEECCCCEEHHHHHCCCEEHHHHHHHHHHCCCCCCHHHH
LRMKQDFKGLRMYHCHILEHEDLGMMGNLEVKE
HEEHHCCCCEEEEEEEEEECCCCCCCCCCEECC
>Mature Secondary Structure
MNRRNFLKFNALTLASMGVAYANPMHDMHSMHKNHSINHDLDTSFINFAPKNLKLLDPKQ
CCCCCEEEEEEEEHHHCCHHHCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCEEECCCC
FPQGEILKALPLLKNESKEKNIFRATLEIKENHIELIKGKKTLFYTYNGLVPAPKIEVFE
CCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCEEEEEECCEEEEEEECCCCCCCEEEEEC
GDKLEILVKNKLKEATTIHWHGVPVPPDQDGSPHDPILAGEERIYRFEIPQDSAGTYWYH
CCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCEEEEC
PHPHYTASKQVFMGLAGAFVIKAKKDALSHLKEKDLMISDLRLDENAQIPNNNLNDWLNG
CCCCCCCCHHHHHHCCEEEEEEECHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHCCC
REGEFVLINGQFKPKIKLATNERIRIYNATAARYLNLRIQGAKFILVGTDGGLIEKAIYK
CCCCEEEECCCCCCEEEEECCCEEEEEECCEEEEEEEEEECEEEEEEECCCCHHHHHHHH
EELFLSPASRVEVLIDAPKDGEFRLESAYYDRDKMMVEEEPNTLFLASISLKKEKLELPK
HHHHCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEECCCCEEEEEEEECCHHHHCCCC
NLKIFKPLEEPKEFKEIIMSEDHMQMHGMMGKSENELKIALASMFLINGKSYDLKRIDLS
CCEEECCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCEEEEECC
SKLGVVEDWIVINKSHMDHPFHIHGTQFELISSKLNGKVQKAEFRAFRDTINVRPNEELR
CCCCCEEEEEEEECCCCCCCEEEECCCCEEHHHHHCCCEEHHHHHHHHHHCCCCCCHHHH
LRMKQDFKGLRMYHCHILEHEDLGMMGNLEVKE
HEEHHCCCCEEEEEEEEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA