Click here to switch to the map view.

The map label for this gene is neuA [H]

Identifier: 57238363

GI number: 57238363

Start: 1398312

End: 1399010

Strand: Direct

Name: neuA [H]

Synonym: CJE1506

Alternate gene names: 57238363

Gene position: 1398312-1399010 (Clockwise)

Preceding gene: 57238361

Following gene: 57238364

Centisome position: 78.65

GC content: 31.33

Gene sequence:

>699_bases
ATGAAAAATCTTTGTATCATCCCTGCTCGTGGTGGATCAAAAAGAATTCCTAGAAAAAATATCATTGATTTTCTAGGTAA
ACCTTTAATCGCTTATAGCATAGAAAATGCTTTAAATTCAGGCATTTTTGATGAAGTAGTGCTTTCAAGCGATGATGAAG
AAATCATAGAAGTAGCCTTAAAATACGGTGCAAAAGCTCCATTTGTGCGTGATAAAAATTTAAGCGATGATTATGCTTCA
AGCACTGCTGCAGTGCAAAATGCCATAGAAATTTTACAAAGCCAAAATCAAATTTATGATCATGTCTGTTGTCTTTATGC
TACTGCTCCGCTTTTAAATAAAAACATTTTAAAACAAGCTTATGAAAAATTTATACAAAATGAAAGCAAGTTTTTATTTG
CCGCCACTGAGTTTGAGTATCCTATACAAAGGGCTTTTTATCTAAATGAGAATAATCAAGTTTATATGTTTGATGAAAAA
CATTATAAAAGTCGTTCACAAGACTTAACAAAAGCTTATCACGATGCAGGAGCTTTTTATTTTGGCACAAGTAAAGCTTG
GCTTGAAGAAGATTTTATATTTAAACCTCATTCTAGCGTGTTTGTATTGCCAAGAAATTTAGTTTGCGATATAGATACCA
TGCAAGATTTAGAATTTGCAAAAATACTTTATAAGGCAAATCATGAAAGTGCTTTTTAG

Upstream 100 bases:

>100_bases
TTATGAGCATTATTCCACCCCGTTTGCATTATTTTATTGTATTTTAAAGACAATTATACTTAAATTTTAGTAAAATAAAA
CACAAAAACAAGGCTTAACT

Downstream 100 bases:

>100_bases
AAGCGATAGCTCCAGTCAAATAGGCTTTGGACACATTAAACGCGATCTAGTCTTAGCTAAACAATATAGCGATGTAAGTT
TTGCTTGTTTGCCTTTAGAA

Product: acylneuraminate cytidylyltransferase

Products: diphosphate; CMP-N-acylneuraminate

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKNLCIIPARGGSKRIPRKNIIDFLGKPLIAYSIENALNSGIFDEVVLSSDDEEIIEVALKYGAKAPFVRDKNLSDDYAS
STAAVQNAIEILQSQNQIYDHVCCLYATAPLLNKNILKQAYEKFIQNESKFLFAATEFEYPIQRAFYLNENNQVYMFDEK
HYKSRSQDLTKAYHDAGAFYFGTSKAWLEEDFIFKPHSSVFVLPRNLVCDIDTMQDLEFAKILYKANHESAF

Sequences:

>Translated_232_residues
MKNLCIIPARGGSKRIPRKNIIDFLGKPLIAYSIENALNSGIFDEVVLSSDDEEIIEVALKYGAKAPFVRDKNLSDDYAS
STAAVQNAIEILQSQNQIYDHVCCLYATAPLLNKNILKQAYEKFIQNESKFLFAATEFEYPIQRAFYLNENNQVYMFDEK
HYKSRSQDLTKAYHDAGAFYFGTSKAWLEEDFIFKPHSSVFVLPRNLVCDIDTMQDLEFAKILYKANHESAF
>Mature_232_residues
MKNLCIIPARGGSKRIPRKNIIDFLGKPLIAYSIENALNSGIFDEVVLSSDDEEIIEVALKYGAKAPFVRDKNLSDDYAS
STAAVQNAIEILQSQNQIYDHVCCLYATAPLLNKNILKQAYEKFIQNESKFLFAATEFEYPIQRAFYLNENNQVYMFDEK
HYKSRSQDLTKAYHDAGAFYFGTSKAWLEEDFIFKPHSSVFVLPRNLVCDIDTMQDLEFAKILYKANHESAF

Specific function: Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin [H]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=180, Percent_Identity=32.7777777777778, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: 2.7.7.43

Molecular weight: Translated: 26573; Mature: 26573

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLCIIPARGGSKRIPRKNIIDFLGKPLIAYSIENALNSGIFDEVVLSSDDEEIIEVAL
CCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHH
KYGAKAPFVRDKNLSDDYASSTAAVQNAIEILQSQNQIYDHVCCLYATAPLLNKNILKQA
HHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YEKFIQNESKFLFAATEFEYPIQRAFYLNENNQVYMFDEKHYKSRSQDLTKAYHDAGAFY
HHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCEE
FGTSKAWLEEDFIFKPHSSVFVLPRNLVCDIDTMQDLEFAKILYKANHESAF
ECCCHHHHCCCCEECCCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNLCIIPARGGSKRIPRKNIIDFLGKPLIAYSIENALNSGIFDEVVLSSDDEEIIEVAL
CCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHH
KYGAKAPFVRDKNLSDDYASSTAAVQNAIEILQSQNQIYDHVCCLYATAPLLNKNILKQA
HHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YEKFIQNESKFLFAATEFEYPIQRAFYLNENNQVYMFDEKHYKSRSQDLTKAYHDAGAFY
HHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCEE
FGTSKAWLEEDFIFKPHSSVFVLPRNLVCDIDTMQDLEFAKILYKANHESAF
ECCCHHHHCCCCEECCCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; N-acylneuraminate

Specific reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8825781 [H]