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The map label for this gene is trpC

Identifier: 57238297

GI number: 57238297

Start: 541255

End: 542031

Strand: Direct

Name: trpC

Synonym: CJE0606

Alternate gene names: 57238297

Gene position: 541255-542031 (Clockwise)

Preceding gene: 57238298

Following gene: 57238296

Centisome position: 30.44

GC content: 32.3

Gene sequence:

>777_bases
ATGATATTGGATAAAATTTTTGAAAAAACAAAAGAAGATTTAAAAGAACGCAAACTAAAACTTCCTTATGATATGTTAGG
GCGTTCTTTAGCTTCAAATCCTTTCTTTCCAAAAGATGTGATTAAGGCTTTAAAAAGAGTAGAAAAAGAAGTTAAAATCA
TAGCAGAAGTAAAAAAAGCAAGCCCTAGCAAGGGAGTCATTAGAGAAGACTTTGATCCTTTGAGTATCGCTTTAAATTAT
GAGAAGAACAAAGCTGCGGCGATTTCTGTTTTAACTGAGCCGCATTTTTTTAAAGGTTCTTTAGAATACTTAAGTCTTAT
ACGCCGTTATACGCAAATTCCTTTACTTAGAAAAGATTTTATCTTTGATGAGTATCAAATTTTAGAAGCTTTGGTTTATG
GGGCGGATTTTGTATTATTAATCGCTAAAATGCTAAGCATGAAAGAGCTTAAAAAACTGCTTGAGTTTGCAAGACATTTA
GGTCTTGAGGCTTTGGTTGAAATTCATGATAAAGAGGATTTGAGTAAGGCTATTTTTGCTGGAGCGGATATCATTGGTAT
CAATCATCGTAATTTAGAGGATTTTACTATGGATATGAGTTTGTGCGAAAAACTTATCCCACAAATCCCAAATTCAAAAA
TCATCATCGCAGAAAGTGGTTTAGAAAATAAAGAATTTTTAGAGCATTTGCAAAATTTAGGCGTTGATGCTTTTTTAATC
GGCGAATATTTTATGCGCGAAAAAGATGAAGGAAAGGCTTTAAAAGCTTTGCTTTAA

Upstream 100 bases:

>100_bases
AAGCATGGGAAATTTTAAAACAAACATTAGATGATAAAGAATTTGCAAATTCTGATGAGAGCAAAGCTCATATAAAAGCG
ATAAAGGCGTGTATAAAACC

Downstream 100 bases:

>100_bases
GGAGGGAAAATGCAGTATTTGTATGCACCATGGCGGAGTGAGTATTTTGAAAAAGAAAAAAGCATTTGTCCATTTTGTGA
TTGTGCTAATAAGATCAAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKASPSKGVIREDFDPLSIALNY
EKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDFIFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHL
GLEALVEIHDKEDLSKAIFAGADIIGINHRNLEDFTMDMSLCEKLIPQIPNSKIIIAESGLENKEFLEHLQNLGVDAFLI
GEYFMREKDEGKALKALL

Sequences:

>Translated_258_residues
MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKASPSKGVIREDFDPLSIALNY
EKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDFIFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHL
GLEALVEIHDKEDLSKAIFAGADIIGINHRNLEDFTMDMSLCEKLIPQIPNSKIIIAESGLENKEFLEHLQNLGVDAFLI
GEYFMREKDEGKALKALL
>Mature_258_residues
MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKASPSKGVIREDFDPLSIALNY
EKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDFIFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHL
GLEALVEIHDKEDLSKAIFAGADIIGINHRNLEDFTMDMSLCEKLIPQIPNSKIIIAESGLENKEFLEHLQNLGVDAFLI
GEYFMREKDEGKALKALL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=39.5121951219512, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=263, Percent_Identity=39.9239543726236, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CAMJ8 (A8FKS2)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001482036.1
- ProteinModelPortal:   A8FKS2
- SMR:   A8FKS2
- STRING:   A8FKS2
- GeneID:   5617907
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_0460
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   CJEJ407148:C8J_0460-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29573; Mature: 29573

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
SPSKGVIREDFDPLSIALNYEKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDF
CCCCCCHHCCCCCEEEEEECCCCCHHEEEEECCCCHHCCHHHHHHHHHHHHHCCHHHHHH
IFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHLGLEALVEIHDKEDLSKAIFA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHC
GADIIGINHRNLEDFTMDMSLCEKLIPQIPNSKIIIAESGLENKEFLEHLQNLGVDAFLI
CCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
GEYFMREKDEGKALKALL
HHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MILDKIFEKTKEDLKERKLKLPYDMLGRSLASNPFFPKDVIKALKRVEKEVKIIAEVKKA
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
SPSKGVIREDFDPLSIALNYEKNKAAAISVLTEPHFFKGSLEYLSLIRRYTQIPLLRKDF
CCCCCCHHCCCCCEEEEEECCCCCHHEEEEECCCCHHCCHHHHHHHHHHHHHCCHHHHHH
IFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHLGLEALVEIHDKEDLSKAIFA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHC
GADIIGINHRNLEDFTMDMSLCEKLIPQIPNSKIIIAESGLENKEFLEHLQNLGVDAFLI
CCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHH
GEYFMREKDEGKALKALL
HHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA