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The map label for this gene is proA [H]

Identifier: 57238242

GI number: 57238242

Start: 598659

End: 599891

Strand: Reverse

Name: proA [H]

Synonym: CJE0662

Alternate gene names: 57238242

Gene position: 599891-598659 (Counterclockwise)

Preceding gene: 57238240

Following gene: 57238243

Centisome position: 33.74

GC content: 31.31

Gene sequence:

>1233_bases
ATGCGAAATTTGCTTGAAAATATTAAGAAAAATTCTCAAAAACTACTTAACTTAACGCCCAAAGATAAAGAAAAAATTAT
TCTAAAATTAGCTCAAATTTTAAGAGAAAATTTCAAAATTATCCTAGAAGCAAATAAAAAAGATATGGCAAATTTCACAA
AAAGCGGAGCAATGAAAGATAGGCTTTTGTTAGATGAAAAACGTATTTTAGCTCTTTGCGAAGGCCTAGAAAAAATCGCT
TACATCGAAGATCCTATAGGCAAAATTTCTAAAGGCTGGAAAAATTATGCGGGTTTAAACATACAAAAAATAAGCATTCC
TTTAGGACTCATTTGTGTTATTTACGAAGCAAGGCCTAGTCTTAGCGCTGAAATCGCAGCTTTAATGATAAAAAGTTCCA
ATGCTTGTGTATTTAAAGGCGGAAGTGAAGCAAAATTTACAAATGAGGCTATATTTACTCTTGTTAATAAAGTACTTAAG
GAATTTGATTTGCAAGATTGTTTTGCTATGTTTACCCAAAGAGATGAAATCTTGCAAATTCTAGCCTTTGATGATTTAAT
CGATGTGATCATACCTCGCGGAAGTTCAAATATGATACAAGAAATTGCAAACAATACCAAAATTCCTCTCATTAAGCAAA
ATAAAGGCTTGTGTCATGCTTTTGTAGATCAAAGTGCTAACTTAGATATGGCTTTAAAAATAATCCTTAATGCAAAGTGT
CAAAGAGTAAGTGTTTGTAACGCTTTAGAAACGCTTTTAATCCATGAAAAAATTGCTAAAAATTTTATAAGTCTTTTAAT
ACCTGAATTTGAAAAATTTAAGGTAAAAATTCACGCCCATGAAAATACTTTGGCTTATTTTAACAACTCAAATTTAGAAA
TTTTTAAAGCAAATGAAAATACCTTTGATACAGAATGGCTTGATTTTGCTTTAAGTGTAAAATTAGTAAAAGATTGCGAT
GAAGCTATAGAGCATATCAATAAACACAGCTCCTTGCATTCTGAAACCATTATCTCAAATGATGCTTCAAATATCGCTAA
ATTTCAACGCCTTATAAACTCATCTTGTATTTATGCTAATGCTTCAACGCGTTTTAGCGATGGAGGAGAATTTGGCTTTG
GTGGAGAAGTTGGAATTTCAACCAGCAAATTGCATGCAAGAGGTCCTATGGGGATTGAAGATATTTGCACTTATAAATAT
ATAATCAATAGGGAAGGACAAATTCGAGAGTGA

Upstream 100 bases:

>100_bases
ACCTACTACAATTAAATCTATTTTTTTCATTTATATTTACCTTTCAATTCTAAATTTTTTTGTATAATTTATCAAGTTTT
TTGTAAATAAAGGATTAAAA

Downstream 100 bases:

>100_bases
ATAAAATAGAAATACTAAAGCAACACTTTAAAGAAATTGCTAAATTAAATTCAAGCGAACAAGTTTGGCAAATGCCTTTT
TTTGCGGCTTTAGGCGTAGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRNLLENIKKNSQKLLNLTPKDKEKIILKLAQILRENFKIILEANKKDMANFTKSGAMKDRLLLDEKRILALCEGLEKIA
YIEDPIGKISKGWKNYAGLNIQKISIPLGLICVIYEARPSLSAEIAALMIKSSNACVFKGGSEAKFTNEAIFTLVNKVLK
EFDLQDCFAMFTQRDEILQILAFDDLIDVIIPRGSSNMIQEIANNTKIPLIKQNKGLCHAFVDQSANLDMALKIILNAKC
QRVSVCNALETLLIHEKIAKNFISLLIPEFEKFKVKIHAHENTLAYFNNSNLEIFKANENTFDTEWLDFALSVKLVKDCD
EAIEHINKHSSLHSETIISNDASNIAKFQRLINSSCIYANASTRFSDGGEFGFGGEVGISTSKLHARGPMGIEDICTYKY
IINREGQIRE

Sequences:

>Translated_410_residues
MRNLLENIKKNSQKLLNLTPKDKEKIILKLAQILRENFKIILEANKKDMANFTKSGAMKDRLLLDEKRILALCEGLEKIA
YIEDPIGKISKGWKNYAGLNIQKISIPLGLICVIYEARPSLSAEIAALMIKSSNACVFKGGSEAKFTNEAIFTLVNKVLK
EFDLQDCFAMFTQRDEILQILAFDDLIDVIIPRGSSNMIQEIANNTKIPLIKQNKGLCHAFVDQSANLDMALKIILNAKC
QRVSVCNALETLLIHEKIAKNFISLLIPEFEKFKVKIHAHENTLAYFNNSNLEIFKANENTFDTEWLDFALSVKLVKDCD
EAIEHINKHSSLHSETIISNDASNIAKFQRLINSSCIYANASTRFSDGGEFGFGGEVGISTSKLHARGPMGIEDICTYKY
IINREGQIRE
>Mature_410_residues
MRNLLENIKKNSQKLLNLTPKDKEKIILKLAQILRENFKIILEANKKDMANFTKSGAMKDRLLLDEKRILALCEGLEKIA
YIEDPIGKISKGWKNYAGLNIQKISIPLGLICVIYEARPSLSAEIAALMIKSSNACVFKGGSEAKFTNEAIFTLVNKVLK
EFDLQDCFAMFTQRDEILQILAFDDLIDVIIPRGSSNMIQEIANNTKIPLIKQNKGLCHAFVDQSANLDMALKIILNAKC
QRVSVCNALETLLIHEKIAKNFISLLIPEFEKFKVKIHAHENTLAYFNNSNLEIFKANENTFDTEWLDFALSVKLVKDCD
EAIEHINKHSSLHSETIISNDASNIAKFQRLINSSCIYANASTRFSDGGEFGFGGEVGISTSKLHARGPMGIEDICTYKY
IINREGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=402, Percent_Identity=34.3283582089552, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI62912457, Length=402, Percent_Identity=34.3283582089552, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1786438, Length=399, Percent_Identity=37.844611528822, Blast_Score=296, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=33.6561743341404, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=33.6561743341404, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=35.5813953488372, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=34.7087378640777, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 46139; Mature: 46139

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLLENIKKNSQKLLNLTPKDKEKIILKLAQILRENFKIILEANKKDMANFTKSGAMKD
CCHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHH
RLLLDEKRILALCEGLEKIAYIEDPIGKISKGWKNYAGLNIQKISIPLGLICVIYEARPS
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCC
LSAEIAALMIKSSNACVFKGGSEAKFTNEAIFTLVNKVLKEFDLQDCFAMFTQRDEILQI
CHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHH
LAFDDLIDVIIPRGSSNMIQEIANNTKIPLIKQNKGLCHAFVDQSANLDMALKIILNAKC
HHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCEEHHHCCCCCCCHHHHHHHHCCC
QRVSVCNALETLLIHEKIAKNFISLLIPEFEKFKVKIHAHENTLAYFNNSNLEIFKANEN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCCEEEEECCCC
TFDTEWLDFALSVKLVKDCDEAIEHINKHSSLHSETIISNDASNIAKFQRLINSSCIYAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCEEEEC
ASTRFSDGGEFGFGGEVGISTSKLHARGPMGIEDICTYKYIINREGQIRE
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure
MRNLLENIKKNSQKLLNLTPKDKEKIILKLAQILRENFKIILEANKKDMANFTKSGAMKD
CCHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHH
RLLLDEKRILALCEGLEKIAYIEDPIGKISKGWKNYAGLNIQKISIPLGLICVIYEARPS
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCC
LSAEIAALMIKSSNACVFKGGSEAKFTNEAIFTLVNKVLKEFDLQDCFAMFTQRDEILQI
CHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHH
LAFDDLIDVIIPRGSSNMIQEIANNTKIPLIKQNKGLCHAFVDQSANLDMALKIILNAKC
HHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCEEHHHCCCCCCCHHHHHHHHCCC
QRVSVCNALETLLIHEKIAKNFISLLIPEFEKFKVKIHAHENTLAYFNNSNLEIFKANEN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCCEEEEECCCC
TFDTEWLDFALSVKLVKDCDEAIEHINKHSSLHSETIISNDASNIAKFQRLINSSCIYAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCEEEEC
ASTRFSDGGEFGFGGEVGISTSKLHARGPMGIEDICTYKYIINREGQIRE
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8341262; 10688204 [H]