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The map label for this gene is cusC [C]

Identifier: 57238196

GI number: 57238196

Start: 643915

End: 645285

Strand: Direct

Name: cusC [C]

Synonym: CJE0711

Alternate gene names: 57238196

Gene position: 643915-645285 (Clockwise)

Preceding gene: 57238197

Following gene: 57238191

Centisome position: 36.22

GC content: 26.99

Gene sequence:

>1371_bases
ATGAAAATAATACTTAGCATTTTTTTAGCATTTTTCTTGAGCGCTTGTGGTGTAAAACTTAGCTTGCCTAAAGAAGTTGA
TTTAACTCAAGAACAAATGAAAGATTTAAATCTTACTTATGATTGGTATAGATCTTATGATAATGCAAAATTAAATGAAT
TTCTAAATTTTGTTTTATTGAATAATAGTGATATTAATATTGCTAGAAAAACTTTGCTTTCGGCTTTGGCTAGAGCTGAT
TTGATTGATTATGATTTATATCCGACTTTAAGTGGAAATTTGGGTTTTGGTGCGGATAAAGATTTAAATTCAGGCAAACA
AAGTAAAAATTTCAATAATTCTTTAAATTTAAGCTATGAGCTTGATATTTATGGCAAATTAAGAGATAGTGCAAGTGCGA
GTGAATTTAGTGCAAAAGCAAGTGCTTATGATCTTGAAAATTTAAAAATAAGTATGATCAATACAGCTTTAAATGATGTG
TTTGAGCTGGCTTATTTTAACGATGTAGATAAATTGCTTCGAGCTTATCTTTCAAATTTAGAACAAATGAAAGAGCTTTA
TAACTATAAATACAAGCTTGGAAAAATAGAAGAATTAGATCTTTTAAACATAGAACAAAGCTTATTAAGAGCTAAACAAA
ATTTATTAAGCAATGATCAAAATCGTAATTTACTCATAAAAAATTTACAAGATTTATTGGCAAGGCAAGAAGGTTTTGCT
TACATAGAGTATTTTAAAACTTTATCTTTAAATGATTTTAAAACCTTAAGTCCTGATTTTAATATACCTTTAAAAGCTTT
AGCGTACCGTGCAGATGTGAGATCTAAACTCAATAGCTTAAAATCAGCCTTTAAGGATTATTCTTCCATGCAAAAATCTA
TTTTGCCTAGTATTTCTTTAGGTGGAGCATTAAGCGGAAGTGATAAAAAAATCGATGATAGTTTTAAATTTGAAATTTTA
AGTGGCAATGTTAAGATTTCTTTACCTTTCTTAGATTATGGTAGGGTAAAGCAAAATATCAAAATTTCACAATTTATTTA
TGAGCAACTTTTAATTTCTTATGAGCAAACTTTGCAAAGTGCGATGAATGAATTTGCATTGAATTATAAAGATTATCAAA
GCGACACCTTGCTTTTGCAAAATTTGCAAAATATTAACATTAAACAAGAGCTTATCACTAAGGCGTATTATGAAAAATAT
ATTTTAGGAAAAAGTGAATTAAAAGATTATTTGGATGCAAACAATACTTTAAATTCTACCCAGCAAGAATTTTTAAGAGC
TAGATTTAATCTTTTAAAAACCATTAATTCTTACTATCAAATCACAGCTTTAAGTTTTAATGATGAAAACTTAGAATTTC
CTAAGTATTAA

Upstream 100 bases:

>100_bases
GGACTTTTAAGTTCTATGTTTATCGGTGTGGTTTTTGGTTTTTTCCCTGCAAGAAATGCAGCAAATTTAAATCCTATTAG
TGCATTATCAAAGGAATAAA

Downstream 100 bases:

>100_bases
ATTTAATAATCAATGATATTTTTTAAATCCTCGAGTAACTTTTTAGCCATCAGCTCATAGCCTTTTATAGTAAGATGTAC
ATCATTGAGCGAAAGCTTTT

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKIILSIFLAFFLSACGVKLSLPKEVDLTQEQMKDLNLTYDWYRSYDNAKLNEFLNFVLLNNSDINIARKTLLSALARAD
LIDYDLYPTLSGNLGFGADKDLNSGKQSKNFNNSLNLSYELDIYGKLRDSASASEFSAKASAYDLENLKISMINTALNDV
FELAYFNDVDKLLRAYLSNLEQMKELYNYKYKLGKIEELDLLNIEQSLLRAKQNLLSNDQNRNLLIKNLQDLLARQEGFA
YIEYFKTLSLNDFKTLSPDFNIPLKALAYRADVRSKLNSLKSAFKDYSSMQKSILPSISLGGALSGSDKKIDDSFKFEIL
SGNVKISLPFLDYGRVKQNIKISQFIYEQLLISYEQTLQSAMNEFALNYKDYQSDTLLLQNLQNINIKQELITKAYYEKY
ILGKSELKDYLDANNTLNSTQQEFLRARFNLLKTINSYYQITALSFNDENLEFPKY

Sequences:

>Translated_456_residues
MKIILSIFLAFFLSACGVKLSLPKEVDLTQEQMKDLNLTYDWYRSYDNAKLNEFLNFVLLNNSDINIARKTLLSALARAD
LIDYDLYPTLSGNLGFGADKDLNSGKQSKNFNNSLNLSYELDIYGKLRDSASASEFSAKASAYDLENLKISMINTALNDV
FELAYFNDVDKLLRAYLSNLEQMKELYNYKYKLGKIEELDLLNIEQSLLRAKQNLLSNDQNRNLLIKNLQDLLARQEGFA
YIEYFKTLSLNDFKTLSPDFNIPLKALAYRADVRSKLNSLKSAFKDYSSMQKSILPSISLGGALSGSDKKIDDSFKFEIL
SGNVKISLPFLDYGRVKQNIKISQFIYEQLLISYEQTLQSAMNEFALNYKDYQSDTLLLQNLQNINIKQELITKAYYEKY
ILGKSELKDYLDANNTLNSTQQEFLRARFNLLKTINSYYQITALSFNDENLEFPKY
>Mature_456_residues
MKIILSIFLAFFLSACGVKLSLPKEVDLTQEQMKDLNLTYDWYRSYDNAKLNEFLNFVLLNNSDINIARKTLLSALARAD
LIDYDLYPTLSGNLGFGADKDLNSGKQSKNFNNSLNLSYELDIYGKLRDSASASEFSAKASAYDLENLKISMINTALNDV
FELAYFNDVDKLLRAYLSNLEQMKELYNYKYKLGKIEELDLLNIEQSLLRAKQNLLSNDQNRNLLIKNLQDLLARQEGFA
YIEYFKTLSLNDFKTLSPDFNIPLKALAYRADVRSKLNSLKSAFKDYSSMQKSILPSISLGGALSGSDKKIDDSFKFEIL
SGNVKISLPFLDYGRVKQNIKISQFIYEQLLISYEQTLQSAMNEFALNYKDYQSDTLLLQNLQNINIKQELITKAYYEKY
ILGKSELKDYLDANNTLNSTQQEFLRARFNLLKTINSYYQITALSFNDENLEFPKY

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=473, Percent_Identity=21.7758985200846, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52468; Mature: 52468

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILSIFLAFFLSACGVKLSLPKEVDLTQEQMKDLNLTYDWYRSYDNAKLNEFLNFVLL
CHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHEEEEE
NNSDINIARKTLLSALARADLIDYDLYPTLSGNLGFGADKDLNSGKQSKNFNNSLNLSYE
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
LDIYGKLRDSASASEFSAKASAYDLENLKISMINTALNDVFELAYFNDVDKLLRAYLSNL
EEEEEECCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMKELYNYKYKLGKIEELDLLNIEQSLLRAKQNLLSNDQNRNLLIKNLQDLLARQEGFA
HHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
YIEYFKTLSLNDFKTLSPDFNIPLKALAYRADVRSKLNSLKSAFKDYSSMQKSILPSISL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGALSGSDKKIDDSFKFEILSGNVKISLPFLDYGRVKQNIKISQFIYEQLLISYEQTLQS
CCCCCCCCCCCCCCEEEEEEECCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMNEFALNYKDYQSDTLLLQNLQNINIKQELITKAYYEKYILGKSELKDYLDANNTLNST
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
QQEFLRARFNLLKTINSYYQITALSFNDENLEFPKY
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKIILSIFLAFFLSACGVKLSLPKEVDLTQEQMKDLNLTYDWYRSYDNAKLNEFLNFVLL
CHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHEEEEE
NNSDINIARKTLLSALARADLIDYDLYPTLSGNLGFGADKDLNSGKQSKNFNNSLNLSYE
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
LDIYGKLRDSASASEFSAKASAYDLENLKISMINTALNDVFELAYFNDVDKLLRAYLSNL
EEEEEECCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQMKELYNYKYKLGKIEELDLLNIEQSLLRAKQNLLSNDQNRNLLIKNLQDLLARQEGFA
HHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
YIEYFKTLSLNDFKTLSPDFNIPLKALAYRADVRSKLNSLKSAFKDYSSMQKSILPSISL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGALSGSDKKIDDSFKFEILSGNVKISLPFLDYGRVKQNIKISQFIYEQLLISYEQTLQS
CCCCCCCCCCCCCCEEEEEEECCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AMNEFALNYKDYQSDTLLLQNLQNINIKQELITKAYYEKYILGKSELKDYLDANNTLNST
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
QQEFLRARFNLLKTINSYYQITALSFNDENLEFPKY
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]