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The map label for this gene is hemE [H]

Identifier: 57238116

GI number: 57238116

Start: 1291701

End: 1292723

Strand: Direct

Name: hemE [H]

Synonym: CJE1379

Alternate gene names: 57238116

Gene position: 1291701-1292723 (Clockwise)

Preceding gene: 57238115

Following gene: 57238117

Centisome position: 72.66

GC content: 31.87

Gene sequence:

>1023_bases
ATGATTTTTATCGATGCTTGCTTTAAAAAACCTACACCCTACACCCCTATTTGGATGATGCGTCAAGCAGGAAGGTATTT
GCCAGAATATATGGAAGTAAGAAAACAAGCGGGTGATTTTCTCTCTTTATGCAAAGACTATAAAAAAGCTTCTGAAGTTT
CTTTACAGCCTATTGATATTTTAGATGTAGATGCAGCAATCATTTTTTCAGATATCTTAGTTGTTCCTCTTGAAATGGGT
ATGAATTTACGTTTTGAAAAAGGAGAAGGGCCTGTTTTTGATAATCCTATTTCAACCCTAGAAGATTTAGAAAAACTTGA
CGATCAAAATGCACATAAAAAATTAAATTATGTCTATGATGCCTTAAAGCTTACAAGAGAAAAATTATCTCAAAACAAGG
CTTTAATAGGATTTTGCGGAAGCCCTTGGACTATAGCTACCTATATGATAGAAGGAAGTGGAAGTAAAAATTATGCAAAG
TGTAAAAAAATGCTTTATCAAAACCCAGAACTTTTACATAAAATTCTAAACAAACTAACTCAAGTTTTAAAACTTTATTT
AGAAGAGCAAATTAAAGCAGGTGCTAATGCTATACAAATTTTTGATAGCTGGGCAAGTGCTTTAGAATATGATAAGTTTT
TTGAATTCTCTTTTAATTATATGCTTGAAATTTCAAATTTTATTAAAAGCAAATACCCAAATATACCTGTAATTTTATTC
CCTAAAGGCATTAGCGGTTATTTGGATAGAATCGATGGTAATTTTGATGTTTTTGGAGTTGATTGGAGCACTCCGCTTGA
TTTAGCACGTGATAAACTATCGCACAAATACACTCTTCAAGGCAACATGGAACCTTGTAGACTTTATGATAAAAATGCCA
TCAAAGAAGGAGTCGGAAAAATACTAAAAACCATGCAAAATAAAGCTCATATTTTCAACTTAGGACATGGGATCTTGCCT
GATATTCCTGTTGAAAATGCAAAATATTTTATCAAGCTTGTACAAGAAAGTTCAGCTAAATGA

Upstream 100 bases:

>100_bases
AAAAAATTTATTATTTCCTCTATATGAAGAAAATATAGAAAAATTGACCAATTTAATTTATCAAATTCTGTTATAATTTT
GCTAAAAACAAAGGAAAATA

Downstream 100 bases:

>100_bases
AAATACTCTTTGGTCCTGTTAGCTCAAGGCGTTTTGGAAGATCTTTGGGTATAGATTTAAGCCCTAGTAAAAAACAATGC
AATTTTGATTGTGTTTATTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MIFIDACFKKPTPYTPIWMMRQAGRYLPEYMEVRKQAGDFLSLCKDYKKASEVSLQPIDILDVDAAIIFSDILVVPLEMG
MNLRFEKGEGPVFDNPISTLEDLEKLDDQNAHKKLNYVYDALKLTREKLSQNKALIGFCGSPWTIATYMIEGSGSKNYAK
CKKMLYQNPELLHKILNKLTQVLKLYLEEQIKAGANAIQIFDSWASALEYDKFFEFSFNYMLEISNFIKSKYPNIPVILF
PKGISGYLDRIDGNFDVFGVDWSTPLDLARDKLSHKYTLQGNMEPCRLYDKNAIKEGVGKILKTMQNKAHIFNLGHGILP
DIPVENAKYFIKLVQESSAK

Sequences:

>Translated_340_residues
MIFIDACFKKPTPYTPIWMMRQAGRYLPEYMEVRKQAGDFLSLCKDYKKASEVSLQPIDILDVDAAIIFSDILVVPLEMG
MNLRFEKGEGPVFDNPISTLEDLEKLDDQNAHKKLNYVYDALKLTREKLSQNKALIGFCGSPWTIATYMIEGSGSKNYAK
CKKMLYQNPELLHKILNKLTQVLKLYLEEQIKAGANAIQIFDSWASALEYDKFFEFSFNYMLEISNFIKSKYPNIPVILF
PKGISGYLDRIDGNFDVFGVDWSTPLDLARDKLSHKYTLQGNMEPCRLYDKNAIKEGVGKILKTMQNKAHIFNLGHGILP
DIPVENAKYFIKLVQESSAK
>Mature_340_residues
MIFIDACFKKPTPYTPIWMMRQAGRYLPEYMEVRKQAGDFLSLCKDYKKASEVSLQPIDILDVDAAIIFSDILVVPLEMG
MNLRFEKGEGPVFDNPISTLEDLEKLDDQNAHKKLNYVYDALKLTREKLSQNKALIGFCGSPWTIATYMIEGSGSKNYAK
CKKMLYQNPELLHKILNKLTQVLKLYLEEQIKAGANAIQIFDSWASALEYDKFFEFSFNYMLEISNFIKSKYPNIPVILF
PKGISGYLDRIDGNFDVFGVDWSTPLDLARDKLSHKYTLQGNMEPCRLYDKNAIKEGVGKILKTMQNKAHIFNLGHGILP
DIPVENAKYFIKLVQESSAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=40.3458213256484, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI2367337, Length=343, Percent_Identity=45.1895043731778, Blast_Score=308, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320252, Length=339, Percent_Identity=38.3480825958702, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI19921920, Length=331, Percent_Identity=39.5770392749245, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI221330099, Length=331, Percent_Identity=39.5770392749245, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38909; Mature: 38909

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIDACFKKPTPYTPIWMMRQAGRYLPEYMEVRKQAGDFLSLCKDYKKASEVSLQPIDI
CEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LDVDAAIIFSDILVVPLEMGMNLRFEKGEGPVFDNPISTLEDLEKLDDQNAHKKLNYVYD
ECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
ALKLTREKLSQNKALIGFCGSPWTIATYMIEGSGSKNYAKCKKMLYQNPELLHKILNKLT
HHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHH
QVLKLYLEEQIKAGANAIQIFDSWASALEYDKFFEFSFNYMLEISNFIKSKYPNIPVILF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
PKGISGYLDRIDGNFDVFGVDWSTPLDLARDKLSHKYTLQGNMEPCRLYDKNAIKEGVGK
CCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
ILKTMQNKAHIFNLGHGILPDIPVENAKYFIKLVQESSAK
HHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIFIDACFKKPTPYTPIWMMRQAGRYLPEYMEVRKQAGDFLSLCKDYKKASEVSLQPIDI
CEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LDVDAAIIFSDILVVPLEMGMNLRFEKGEGPVFDNPISTLEDLEKLDDQNAHKKLNYVYD
ECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
ALKLTREKLSQNKALIGFCGSPWTIATYMIEGSGSKNYAKCKKMLYQNPELLHKILNKLT
HHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHH
QVLKLYLEEQIKAGANAIQIFDSWASALEYDKFFEFSFNYMLEISNFIKSKYPNIPVILF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
PKGISGYLDRIDGNFDVFGVDWSTPLDLARDKLSHKYTLQGNMEPCRLYDKNAIKEGVGK
CCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
ILKTMQNKAHIFNLGHGILPDIPVENAKYFIKLVQESSAK
HHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA