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The map label for this gene is pdxA [H]

Identifier: 57238111

GI number: 57238111

Start: 1288144

End: 1289238

Strand: Direct

Name: pdxA [H]

Synonym: CJE1374

Alternate gene names: 57238111

Gene position: 1288144-1289238 (Clockwise)

Preceding gene: 57238110

Following gene: 57238114

Centisome position: 72.46

GC content: 31.78

Gene sequence:

>1095_bases
ATGAAAAAACTAGCCATTAGTATAGGCGATATAAACGGCATAGGACTTGAAATTTTAGTGCGTTCTCATGAAGAACTAAG
CAAAATCTGCACACCTTTTTATTTTATCCACGAAAGCTTGCTTGATAAAGCTTCAAAACTTTTAAATTTAAAACTTTTTA
ATGCAAAAATCGTAGCTTTTAAAGATGGAAAAGACTATGAGTTTAATTTTGTAAAAAAAGAAAATTCTCTTGAAATTTAC
TCTTTCTACCTTCCTTTAGACTTTAAAGTGGATGAAAATTTTGAAATCAAAGCCGGAGAAATAGATACAAAAAGTGGACT
TTATGGTTTTTTAAGTTTTAAGGCGGCAAGTTATTTTGTCTATGAAAAACACGCCCATGCCTTGCTTACTCTACCTATAC
ACAAAAAAGCTTGGGAAGATGCAGGACTTAAATACAAAGGACACACCGATGCTTTAAGGGATTTTTTTAAAAAAAATGCC
ATTATGATGTTAGGTTGCAAAGAACTTTTTGTAGGGCTTTTTAGCGAACATATACCTTTAGCTAAGGTGAGTAAAAAAAT
CACTTTTAAAAATTTAAGTATCTTTTTAAAAGATTTTTACAAAGAAACGCATTTTAAAAAAATGGGGCTTTTAGGTTTTA
ATCCTCACGCTGGAGATTATGGAGTTATAGGCGGAGAAGAAGAAAAGATCATGGAAAAAGCTATAGCCTTTGTTAATGCC
TTTTTACACTCTAAAAAAGATGAAAAATTTTTCAAAAAAGCCTTAAAAGATGAAAATTTGCAAAAAGAATTGCTTTTAAA
TTTTAAAGGCAAGGGCGTTTATCTACCCCATCCTTTAGTGGCTGATACAGCTTTTACTAAGACTGGTTTAAAAAACTGCA
ATCGTTTAGTGGCTATGTATCACGATCTTGCCCTTGCTCCTTTAAAGGCCTTGTATTTTGATAAAAGCATCAATGTAAGT
TTAAATTTACCTATCATACGCGTTAGCGTTGATCATGGCACGGCCTTTGATAAGGCCTATAAAAATGCTAAAATCAACAC
TAAAAGTTATTTTGAAGCGGCCAAATTTGCAATCAATTTACATTCTAAAGCTTAA

Upstream 100 bases:

>100_bases
AAGAAATTTGCGAGCTAAATATAGGACAAAGCATTGTAGCAAGATCTGTATTTACAGGACTTCAAAACGCTATTTTGGAA
ATGAAAGAACTTATTAAAAG

Downstream 100 bases:

>100_bases
ATTTAGCCCTAGAATCAATCAAATCTTCTTTAGCTAAGCTGTCTATAAAATCTTGCAAATCTTTATTGGTATTTAAACTT
TGAGTGAGTAAATTTTCATA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAFKDGKDYEFNFVKKENSLEIY
SFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFVYEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFKKNA
IMMLGCKELFVGLFSEHIPLAKVSKKITFKNLSIFLKDFYKETHFKKMGLLGFNPHAGDYGVIGGEEEKIMEKAIAFVNA
FLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCNRLVAMYHDLALAPLKALYFDKSINVS
LNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAAKFAINLHSKA

Sequences:

>Translated_364_residues
MKKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAFKDGKDYEFNFVKKENSLEIY
SFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFVYEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFKKNA
IMMLGCKELFVGLFSEHIPLAKVSKKITFKNLSIFLKDFYKETHFKKMGLLGFNPHAGDYGVIGGEEEKIMEKAIAFVNA
FLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCNRLVAMYHDLALAPLKALYFDKSINVS
LNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAAKFAINLHSKA
>Mature_364_residues
MKKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAFKDGKDYEFNFVKKENSLEIY
SFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFVYEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFKKNA
IMMLGCKELFVGLFSEHIPLAKVSKKITFKNLSIFLKDFYKETHFKKMGLLGFNPHAGDYGVIGGEEEKIMEKAIAFVNA
FLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCNRLVAMYHDLALAPLKALYFDKSINVS
LNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAAKFAINLHSKA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=373, Percent_Identity=27.0777479892761, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 41382; Mature: 41382

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAF
CCEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
KDGKDYEFNFVKKENSLEIYSFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFV
ECCCCCEEEEEECCCCEEEEEEEEEEEEEECCCCEEEECCCCCCCCCEEEEEHHHHEEEE
YEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFKKNAIMMLGCKELFVGLFSEHIPL
EECCCCEEEEECCCHHHHHCCCCEECCCHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCH
AKVSKKITFKNLSIFLKDFYKETHFKKMGLLGFNPHAGDYGVIGGEEEKIMEKAIAFVNA
HHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCNRLVAMY
HHHCCCHHHHHHHHHCCCCCCHHHHEEECCCEEECCCCCHHCHHHHHHHHHHHHHHHHHH
HDLALAPLKALYFDKSINVSLNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAAKFAINL
HHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHEEEEE
HSKA
CCCC
>Mature Secondary Structure
MKKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAF
CCEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
KDGKDYEFNFVKKENSLEIYSFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFV
ECCCCCEEEEEECCCCEEEEEEEEEEEEEECCCCEEEECCCCCCCCCEEEEEHHHHEEEE
YEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFKKNAIMMLGCKELFVGLFSEHIPL
EECCCCEEEEECCCHHHHHCCCCEECCCHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCH
AKVSKKITFKNLSIFLKDFYKETHFKKMGLLGFNPHAGDYGVIGGEEEKIMEKAIAFVNA
HHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCNRLVAMY
HHHCCCHHHHHHHHHCCCCCCHHHHEEECCCEEECCCCCHHCHHHHHHHHHHHHHHHHHH
HDLALAPLKALYFDKSINVSLNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAAKFAINL
HHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHEEEEE
HSKA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA