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The map label for this gene is groEL [H]

Identifier: 57238093

GI number: 57238093

Start: 1270253

End: 1271890

Strand: Direct

Name: groEL [H]

Synonym: CJE1356

Alternate gene names: 57238093

Gene position: 1270253-1271890 (Clockwise)

Preceding gene: 57238092

Following gene: 57238096

Centisome position: 71.45

GC content: 36.75

Gene sequence:

>1638_bases
ATGGCAAAAGAAATTATTTTTTCAGATGAAGCAAGAAATAAACTTTACGAGGGCGTTAAAAAACTTAATGACGCAGTAAA
AGTAACTATGGGGCCAAGAGGACGCAATGTTTTAATCCAAAAAAGCTTTGGTGCTCCAAGCATTACTAAAGATGGCGTAA
GTGTTGCTAAAGAAGTAGAGCTTAAAGATAGTCTTGAAAATATGGGTGCTTCACTCGTAAGAGAAGTAGCGAGTAAAACA
GCTGATCAAGCAGGCGATGGAACAACTACTGCAACGGTTTTAGCTCATGCAATTTTCAAAGAAGGTTTAAGAAATATCAC
AGCAGGTGCAAATCCTATCGAGGTAAAACGCGGTATGGATAAAGCTTGCGAAGCTATAGTAGCAGAACTTAAAAAACTTT
CTCGCGAAGTAAAAGATAAAAAAGAAATTGCACAAGTTGCTACAATCTCAGCCAACTCTGATGAAAAAATCGGAAATTTA
ATCGCTGATGCCATGGAAAAAGTGGGCAAAGATGGTGTTATCACTGTTGAAGAGGCAAAATCAATCAATGATGAATTAAA
TGTAGTTGAAGGTATGCAATTTGACAGAGGTTATTTAAGCCCTTATTTTATCACTAATGCAGAAAAAATGACAGTAGAGC
TTTCAAGCCCTTATATCCTGCTTTTTGATAAAAAAATTGCAAATTTAAAAGATTTATTACCGGTTTTAGAACAAATTCAA
AAAACAGGCAAACCACTTTTAATTATCGCTGAAGATATTGAAGGCGAAGCGCTTGCAACTTTGGTTGTAAATAAACTTCG
CGGTGTTCTTAATATTTCAGCAGTAAAAGCTCCAGGTTTTGGCGATAGAAGAAAAGCTATGCTTGAAGATATAGCGATTT
TAACAGGTGGAGAAGTGATTTCTGAAGAACTTGGAAGAACTCTTGAAAGTGCGACTATACAAGATCTTGGACAAGCTTCT
AGTGTAATCATCGATAAAGACAATACAACCATAGTAAATGGTGCAGGCGAAAAAGCAAATATCGATGCAAGAGTCAATCA
AATCAAAGCACAAATTGCTGAAACAACTTCAGATTATGACAGAGAAAAATTACAAGAAAGACTTGCAAAATTAAGTGGTG
GTGTTGCAGTTATTAAAGTAGGTGCAGCAACTGAAACTGAAATGAAAGAGAAAAAAGATCGTGTTGATGATGCTTTAAGC
GCTACTAAAGCAGCAGTTGAAGAAGGTATAGTAATCGGTGGTGGTGCAGCGCTTATCAAAGCAAAAGCTAAAATCAAACT
TGATCTACAGGGTGATGAAGCAATTGGCGCAGCTATCGTTGAAAGAGCTTTAAGAGCACCTTTAAGACAAATTGCTGAAA
ATGCAGGATTTGATGCAGGTGTGGTTGTAAATAGCGTAGAAAATGCTAAAGATGAAAACACAGGATTTGATGCTGCAAAA
GGTGAATATGTTAATATGCTTGAAAGTGGAATTATCGATCCTGTTAAAGTAGAAAGAGTAGCTTTACTCAATGCAGTTTC
TGTAGCTAGTATGCTTTTAACCACAGAAGCAACAATTAGTGAAATTAAAGAAGATAAGCCTACTATGCCAGATATGAGCG
GTATGGGAGGAATGGGTGGCATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
ACGGTGGAACAGAAATTAAACTTGATAATAATGAATATTTAGTTTTAAATTTAGATGATATCTTAGGAATTTTAAAATAA
TTTATAAAAAAGGATAAAAA

Downstream 100 bases:

>100_bases
TATCTGCTCTAACCTCTTATCAGCAAGGATTTTCCTTGCTGATTACCAATTTAATTTAAAAACACTCCCTTGATTTTCTA
CAGATTCGCAAATAATCTTA

Product: molecular chaperone GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVELKDSLENMGASLVREVASKT
ADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMDKACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNL
IADAMEKVGKDGVITVEEAKSINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQ
KTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRTLESATIQDLGQAS
SVIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYDREKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIKAKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAK
GEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGGMGGMM

Sequences:

>Translated_545_residues
MAKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVELKDSLENMGASLVREVASKT
ADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMDKACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNL
IADAMEKVGKDGVITVEEAKSINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQ
KTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRTLESATIQDLGQAS
SVIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYDREKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIKAKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAK
GEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGGMGGMM
>Mature_544_residues
AKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVELKDSLENMGASLVREVASKTA
DQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMDKACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNLI
ADAMEKVGKDGVITVEEAKSINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQK
TGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVISEELGRTLESATIQDLGQASS
VIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYDREKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSA
TKAAVEEGIVIGGGAALIKAKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAKG
EYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=52.5519848771267, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=52.5519848771267, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI38455427, Length=548, Percent_Identity=23.9051094890511, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=63.3776091081594, Blast_Score=653, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=50.8506616257089, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI193210679, Length=207, Percent_Identity=47.3429951690821, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17564182, Length=542, Percent_Identity=23.4317343173432, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25144674, Length=172, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566944, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=523, Percent_Identity=53.3460803059273, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322350, Length=532, Percent_Identity=21.9924812030075, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=112, Percent_Identity=30.3571428571429, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641193, Length=532, Percent_Identity=54.5112781954887, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=532, Percent_Identity=54.5112781954887, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=52.1904761904762, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=52.1904761904762, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=52.1904761904762, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=44.3014705882353, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=553, Percent_Identity=35.2622061482821, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI19921262, Length=553, Percent_Identity=35.2622061482821, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24583944, Length=556, Percent_Identity=23.3812949640288, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57941; Mature: 57810

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVE
CCCCEEECCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHH
LKDSLENMGASLVREVASKTADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHH
SINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQ
CCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGRTLESATIQDLGQASSVIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYD
HHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
REKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIK
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHEEE
AKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAK
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHCCCCCCCCCCCCC
GEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MGGMM
CCCCC
>Mature Secondary Structure 
AKEIIFSDEARNKLYEGVKKLNDAVKVTMGPRGRNVLIQKSFGAPSITKDGVSVAKEVE
CCCEEECCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHH
LKDSLENMGASLVREVASKTADQAGDGTTTATVLAHAIFKEGLRNITAGANPIEVKRGMD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KACEAIVAELKKLSREVKDKKEIAQVATISANSDEKIGNLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHH
SINDELNVVEGMQFDRGYLSPYFITNAEKMTVELSSPYILLFDKKIANLKDLLPVLEQIQ
CCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLLIIAEDIEGEALATLVVNKLRGVLNISAVKAPGFGDRRKAMLEDIAILTGGEVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGRTLESATIQDLGQASSVIIDKDNTTIVNGAGEKANIDARVNQIKAQIAETTSDYD
HHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCHHH
REKLQERLAKLSGGVAVIKVGAATETEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIK
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHEEE
AKAKIKLDLQGDEAIGAAIVERALRAPLRQIAENAGFDAGVVVNSVENAKDENTGFDAAK
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHCCCCCCCCCCCCC
GEYVNMLESGIIDPVKVERVALLNAVSVASMLLTTEATISEIKEDKPTMPDMSGMGGMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MGGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA