BacMap

Definition	Campylobacter jejuni RM1221, complete genome.
Accession	NC_003912
Length	1,777,831

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The map label for this gene is accC-1 [H]

Identifier: 57237923

GI number: 57237923

Start: 1098574

End: 1100019

Strand: Reverse

Name: accC-1 [H]

Synonym: CJE1181

Alternate gene names: 57237923

Gene position: 1100019-1098574 (Counterclockwise)

Preceding gene: 57237926

Following gene: 57237922

Centisome position: 61.87

GC content: 33.82

Gene sequence:

>1446_bases
ATGAATCAAATCCATAAAATTCTCATAGCAAATAGAGCTGAAATAGCTGTTAGAGTAATCCGTGCTTGTAGAGATTTACA
TATTAAAAGTGTTGCAGTTTTTACAGAGCCTGATCGTGAATGTTTGCATGTAAAAATCGCAGATGAGGCTTATCGCATAG
GAACGGATGCTATAAGAGGATATTTAGATGTTGCTCGTATTGTCGAGATTGCTAAGGCTTGTGGTGCTGATGCGATCCAT
CCTGGTTATGGATTTTTAAGTGAGAATTACGAATTTGCTAAGGCTTGTGAAGATGCTGGAATTATTTTTATAGGTCCAAA
ATCTGAAGTAATCCATAAGATGGGAAATAAAAATATCGCTCGTAAGTTAATGGCTAAAAATGGCATACCTATTGTTCCAG
GGACTGAAAAATTAAATTCCTATAGCATGGAAGAAATTAAAATTTTTGCTGAGAAGATTGGTTATCCTGTTATTTTAAAA
GCTTCAGGTGGTGGAGGTGGACGCGGAATTCGCGTTGTTCATAAAGAACAAGATCTTGAAAATGCTTTTGAATCTTGCAA
AAGAGAAGCTTTAACATACTTTAATAATGATGAAGTATTTATGGAAAAATATGTAGTTAATCCCAGACATATAGAATTTC
AAATTTTAGGAGATAACTACGGAAATATTATCCATCTTTGTGAAAGGGATTGTTCTATTCAAAGAAGACATCAAAAGGTA
ATTGAGATAGCACCTTGCCCTGGAATTTCAGATAATCTTAGAAAAACCATGGGTGTTACAGCTGTGGCAGCTGCTAAGGC
TGTAGGTTATACAAATGCTGGAACTATAGAGTTTTTGCTTGATGATTATAATCGCTTTTATTTTATGGAAATGAATACAA
GAATTCAAGTTGAGCATCCAATTACTGAAGAAATTACAGGTATTGATCTTATTGTAAGACAAATTCGTATTGCAGCAGGA
GAAATTTTGGACTTAGAACAAAGCGATATTAAACCTAGGGGTTTTGCTATTGAAGCTAGAATTACTGCTGAAAATGTATG
GAAAAATTTTATTCCAAGTCCTGGAAAAATAGGAGAATACTACCCAGCTCTTGGACCATCTGTTAGGGTTGATAGTCATA
TTTATAAAGACTATACTGTGCCGCCTTATTATGATTCCATGCTTGCAAAGCTTATTATTAAAGCAACAAGTTATGATTTA
GCGGTTAATAAACTTGAGCGTGCTTTGAAGGAATTTGTGATTGATGATATTAGAACAACAATACCATTTTTAATTGCCAT
TACAAAAACAAGAGAATTTAGAAGGGGGTATTTAGACACCTCTTTCATAGAAACACATATGCAAGAATTATTAGAAAAAA
CAGAAGATCGTCATCAAGAAAATAAAGAAGAAGTTATAGCTGCAATAGCTGCTACGCTTAAAAAAATACGAGAAAGTAGG
GAATAA

Upstream 100 bases:

>100_bases
AAAGTTTTATTATAACTAAAATAAATTAAATTTTTTGCTAAGTTTTTGTAAGGAAAATTTGCTAAAATTAACAATAAAAA
TATAACAAAAAAGGCAAATT

Downstream 100 bases:

>100_bases
TAGATGGATTTTTTAGACAGTCTTAAAAGTATTAAAAAAGAAATGCAAGCTAACACCAATACTTCAAAATTAGCGAAGAA
ATCAAGCAAGAGTGGTGCAA

Product: acetyl-CoA carboxylase subunit A

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNQIHKILIANRAEIAVRVIRACRDLHIKSVAVFTEPDRECLHVKIADEAYRIGTDAIRGYLDVARIVEIAKACGADAIH
PGYGFLSENYEFAKACEDAGIIFIGPKSEVIHKMGNKNIARKLMAKNGIPIVPGTEKLNSYSMEEIKIFAEKIGYPVILK
ASGGGGGRGIRVVHKEQDLENAFESCKREALTYFNNDEVFMEKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKV
IEIAPCPGISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLDDYNRFYFMEMNTRIQVEHPITEEITGIDLIVRQIRIAAG
EILDLEQSDIKPRGFAIEARITAENVWKNFIPSPGKIGEYYPALGPSVRVDSHIYKDYTVPPYYDSMLAKLIIKATSYDL
AVNKLERALKEFVIDDIRTTIPFLIAITKTREFRRGYLDTSFIETHMQELLEKTEDRHQENKEEVIAAIAATLKKIRESR
E

Sequences:

>Translated_481_residues
MNQIHKILIANRAEIAVRVIRACRDLHIKSVAVFTEPDRECLHVKIADEAYRIGTDAIRGYLDVARIVEIAKACGADAIH
PGYGFLSENYEFAKACEDAGIIFIGPKSEVIHKMGNKNIARKLMAKNGIPIVPGTEKLNSYSMEEIKIFAEKIGYPVILK
ASGGGGGRGIRVVHKEQDLENAFESCKREALTYFNNDEVFMEKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKV
IEIAPCPGISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLDDYNRFYFMEMNTRIQVEHPITEEITGIDLIVRQIRIAAG
EILDLEQSDIKPRGFAIEARITAENVWKNFIPSPGKIGEYYPALGPSVRVDSHIYKDYTVPPYYDSMLAKLIIKATSYDL
AVNKLERALKEFVIDDIRTTIPFLIAITKTREFRRGYLDTSFIETHMQELLEKTEDRHQENKEEVIAAIAATLKKIRESR
E
>Mature_481_residues
MNQIHKILIANRAEIAVRVIRACRDLHIKSVAVFTEPDRECLHVKIADEAYRIGTDAIRGYLDVARIVEIAKACGADAIH
PGYGFLSENYEFAKACEDAGIIFIGPKSEVIHKMGNKNIARKLMAKNGIPIVPGTEKLNSYSMEEIKIFAEKIGYPVILK
ASGGGGGRGIRVVHKEQDLENAFESCKREALTYFNNDEVFMEKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKV
IEIAPCPGISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLDDYNRFYFMEMNTRIQVEHPITEEITGIDLIVRQIRIAAG
EILDLEQSDIKPRGFAIEARITAENVWKNFIPSPGKIGEYYPALGPSVRVDSHIYKDYTVPPYYDSMLAKLIIKATSYDL
AVNKLERALKEFVIDDIRTTIPFLIAITKTREFRRGYLDTSFIETHMQELLEKTEDRHQENKEEVIAAIAATLKKIRESR
E

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=450, Percent_Identity=47.5555555555556, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=464, Percent_Identity=45.0431034482759, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=464, Percent_Identity=45.0431034482759, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=464, Percent_Identity=45.0431034482759, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=43.8478747203579, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=44.3438914027149, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=44.3438914027149, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=32.1637426900585, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=32.1637426900585, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=32.1637426900585, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=32.1637426900585, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=32.1637426900585, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.8447937131631, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI18105007, Length=224, Percent_Identity=22.7678571428571, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=49.8876404494382, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI1786216, Length=238, Percent_Identity=23.109243697479, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562816, Length=465, Percent_Identity=44.7311827956989, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=474, Percent_Identity=44.0928270042194, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567343, Length=478, Percent_Identity=42.0502092050209, Blast_Score=358, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI71997168, Length=439, Percent_Identity=31.2072892938497, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=438, Percent_Identity=31.2785388127854, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.4478527607362, Blast_Score=188, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=456, Percent_Identity=46.4912280701754, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=42.6008968609865, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=456, Percent_Identity=46.9298245614035, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=30.9477756286267, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=31.8872017353579, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=297, Percent_Identity=23.2323232323232, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24651757, Length=452, Percent_Identity=48.4513274336283, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=451, Percent_Identity=47.8935698447894, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=414, Percent_Identity=47.5845410628019, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=32.0939334637965, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=32.0939334637965, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=32.0939334637965, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=32.0939334637965, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 54413; Mature: 54413

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIHKILIANRAEIAVRVIRACRDLHIKSVAVFTEPDRECLHVKIADEAYRIGTDAIRG
CCHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCHHHHCCHHHHHH
YLDVARIVEIAKACGADAIHPGYGFLSENYEFAKACEDAGIIFIGPKSEVIHKMGNKNIA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHHHHHHCCHHHH
RKLMAKNGIPIVPGTEKLNSYSMEEIKIFAEKIGYPVILKASGGGGGRGIRVVHKEQDLE
HHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHH
NAFESCKREALTYFNNDEVFMEKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKV
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHCCCHHHHHHHHH
IEIAPCPGISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLDDYNRFYFMEMNTRIQVEHP
EEEECCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCC
ITEEITGIDLIVRQIRIAAGEILDLEQSDIKPRGFAIEARITAENVWKNFIPSPGKIGEY
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCC
YPALGPSVRVDSHIYKDYTVPPYYDSMLAKLIIKATSYDLAVNKLERALKEFVIDDIRTT
CCCCCCCCEECCCHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IPFLIAITKTREFRRGYLDTSFIETHMQELLEKTEDRHQENKEEVIAAIAATLKKIRESR
HHHHEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
E
C
>Mature Secondary Structure
MNQIHKILIANRAEIAVRVIRACRDLHIKSVAVFTEPDRECLHVKIADEAYRIGTDAIRG
CCHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCHHHHCCHHHHHH
YLDVARIVEIAKACGADAIHPGYGFLSENYEFAKACEDAGIIFIGPKSEVIHKMGNKNIA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCHHHHHHHHCCHHHH
RKLMAKNGIPIVPGTEKLNSYSMEEIKIFAEKIGYPVILKASGGGGGRGIRVVHKEQDLE
HHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHH
NAFESCKREALTYFNNDEVFMEKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKV
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEHHHHCCCHHHHHHHHH
IEIAPCPGISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLDDYNRFYFMEMNTRIQVEHP
EEEECCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCC
ITEEITGIDLIVRQIRIAAGEILDLEQSDIKPRGFAIEARITAENVWKNFIPSPGKIGEY
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCC
YPALGPSVRVDSHIYKDYTVPPYYDSMLAKLIIKATSYDLAVNKLERALKEFVIDDIRTT
CCCCCCCCEECCCHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IPFLIAITKTREFRRGYLDTSFIETHMQELLEKTEDRHQENKEEVIAAIAATLKKIRESR
HHHHEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 9478969 [H]