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The map label for this gene is atoC [H]

Identifier: 57237911

GI number: 57237911

Start: 1083529

End: 1084830

Strand: Reverse

Name: atoC [H]

Synonym: CJE1168

Alternate gene names: 57237911

Gene position: 1084830-1083529 (Counterclockwise)

Preceding gene: 57237912

Following gene: 57237910

Centisome position: 61.02

GC content: 28.8

Gene sequence:

>1302_bases
ATGAATTTAGTCATAGTAGAAGATGATATTAATATGCGCAAATCCTTAGAAATTGCATTAGCAGAGTATGAAGAATTTAA
TATTAAATCTTATAAATCTGCTACTGAAGCTTTAAAAAAAATAGATGAGAATACAGATTTGATTATTACAGATATTAATA
TGCCAGGAATTGATGGTATAGAATTTGTTAAAGCCTGTGAAAATAAATATGATTTTATTATTATGACAGGAAATGCTACT
TTAAGCCGTGCTATAGAAGCGGTTCGTTTGGGAGTAAAAGATTTTTTAACCAAGCCTTTTGATGTTGATACTTTAGTCGA
GGCTATTAAGCGTGCTAAAATCATAAGAGAAAAAACAGCCGATAAAAAAAGCAAAAAAAATGAAAAAAAAGAAGAAAATA
AAGATTTTTTTTCAACTTCTCCTAATTTAGAAAAAACATTAAATTTAAGTCAAAAAGCGGCTAAAACTGATGCCTCTGTA
ATGTTTTTTGGAGAGAGTGGAGTAGGAAAAGAGGTATTTTCTCGTTATATTCACACTCATTCTAAACGCTCTAATAAGCC
TTTTGTTGCTATTAATATGGCAGCCATTCCTGCAAATTTGATTGAAAGTGAGCTTTTTGGTTTTGAAAAAGGTGCTTTTA
CTGATGCTAATGCAACTAAAATAGGGCTTTTTGAAATGGCTAATGAGGGCACTTTATTTTTAGATGAAATTGGCGAAATG
CCTTATGAAATTCAAGCCAAACTTTTAAGAGCTTTGCAAGAAAAAGAAATTACGCGACTTGGAAGTACAAAAAGCATCAA
AATAGATGTAAGAATTATCAGTGCAACTAATGCAAATTTGGATGAAAAAATAAAAAATGGCGAATTTCGTTCAGATTTAT
ATTATCGTTTAAACACTGTTCCTATTAATATCCCGCCTTTAAGAGAGCGTAAAGAAGAAATTTTAGGTATAGCTCAAAAG
GTTTTAGAAGATACTTGTAAAGAATATGATTTTAAGGAAAAACAGCTCAGTCAAGAAGCTAAAAATGCTTTACTTGAATA
TGATTTTCCTGGTAATATTAGAGAATTAATATCCGTTGTACAAAGAGCTTGTATTTTAAGTGAAAATGATGAAATTTCAA
GTGAAGATTTGTTCTTAGAAGCTAGAAGTATAAAAAAAGATGTAAAGAATTTAGAAAAAGAATTGATTTGTGAAGTTCTT
TTAAGTGTAGATTATGACAAGGATCAAGCTTCTCAAATTTTAGGTATGGATATAAAAATTTTAAATGAAAAAATTAAAAA
ATATCAAATAAAGGATAAGTAA

Upstream 100 bases:

>100_bases
TTGGCGAACAAAATGCGATAATTTATTATCTTAAAAAAAAGTAAATTCAAAATTAAGCGCAAATTGGATACTATAGTAGA
AATTTTTTAAAAGGCTTAGG

Downstream 100 bases:

>100_bases
TGTCAAAAAAACAAAAAATAGCCATTGTGGGTGCTACTGGTGCGGTTGGGGAAGAGCTTTTAAATGTTTTAGATGAACTT
GATTTCCCAGTGGAAAGTAT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNLVIVEDDINMRKSLEIALAEYEEFNIKSYKSATEALKKIDENTDLIITDINMPGIDGIEFVKACENKYDFIIMTGNAT
LSRAIEAVRLGVKDFLTKPFDVDTLVEAIKRAKIIREKTADKKSKKNEKKEENKDFFSTSPNLEKTLNLSQKAAKTDASV
MFFGESGVGKEVFSRYIHTHSKRSNKPFVAINMAAIPANLIESELFGFEKGAFTDANATKIGLFEMANEGTLFLDEIGEM
PYEIQAKLLRALQEKEITRLGSTKSIKIDVRIISATNANLDEKIKNGEFRSDLYYRLNTVPINIPPLRERKEEILGIAQK
VLEDTCKEYDFKEKQLSQEAKNALLEYDFPGNIRELISVVQRACILSENDEISSEDLFLEARSIKKDVKNLEKELICEVL
LSVDYDKDQASQILGMDIKILNEKIKKYQIKDK

Sequences:

>Translated_433_residues
MNLVIVEDDINMRKSLEIALAEYEEFNIKSYKSATEALKKIDENTDLIITDINMPGIDGIEFVKACENKYDFIIMTGNAT
LSRAIEAVRLGVKDFLTKPFDVDTLVEAIKRAKIIREKTADKKSKKNEKKEENKDFFSTSPNLEKTLNLSQKAAKTDASV
MFFGESGVGKEVFSRYIHTHSKRSNKPFVAINMAAIPANLIESELFGFEKGAFTDANATKIGLFEMANEGTLFLDEIGEM
PYEIQAKLLRALQEKEITRLGSTKSIKIDVRIISATNANLDEKIKNGEFRSDLYYRLNTVPINIPPLRERKEEILGIAQK
VLEDTCKEYDFKEKQLSQEAKNALLEYDFPGNIRELISVVQRACILSENDEISSEDLFLEARSIKKDVKNLEKELICEVL
LSVDYDKDQASQILGMDIKILNEKIKKYQIKDK
>Mature_433_residues
MNLVIVEDDINMRKSLEIALAEYEEFNIKSYKSATEALKKIDENTDLIITDINMPGIDGIEFVKACENKYDFIIMTGNAT
LSRAIEAVRLGVKDFLTKPFDVDTLVEAIKRAKIIREKTADKKSKKNEKKEENKDFFSTSPNLEKTLNLSQKAAKTDASV
MFFGESGVGKEVFSRYIHTHSKRSNKPFVAINMAAIPANLIESELFGFEKGAFTDANATKIGLFEMANEGTLFLDEIGEM
PYEIQAKLLRALQEKEITRLGSTKSIKIDVRIISATNANLDEKIKNGEFRSDLYYRLNTVPINIPPLRERKEEILGIAQK
VLEDTCKEYDFKEKQLSQEAKNALLEYDFPGNIRELISVVQRACILSENDEISSEDLFLEARSIKKDVKNLEKELICEVL
LSVDYDKDQASQILGMDIKILNEKIKKYQIKDK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=38.1374722838137, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1790299, Length=461, Percent_Identity=34.2733188720174, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1790437, Length=440, Percent_Identity=36.5909090909091, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1788905, Length=376, Percent_Identity=38.563829787234, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI87082117, Length=280, Percent_Identity=42.5, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI1789233, Length=307, Percent_Identity=42.9967426710098, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789087, Length=328, Percent_Identity=39.0243902439024, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1786524, Length=265, Percent_Identity=41.1320754716981, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=35.5555555555556, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87081872, Length=300, Percent_Identity=34.3333333333333, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787583, Length=242, Percent_Identity=37.1900826446281, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=29.7029702970297, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789828, Length=266, Percent_Identity=31.203007518797, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49233; Mature: 49233

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVIVEDDINMRKSLEIALAEYEEFNIKSYKSATEALKKIDENTDLIITDINMPGIDGI
CEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHH
EFVKACENKYDFIIMTGNATLSRAIEAVRLGVKDFLTKPFDVDTLVEAIKRAKIIREKTA
HHHHHHCCCCCEEEEECCHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DKKSKKNEKKEENKDFFSTSPNLEKTLNLSQKAAKTDASVMFFGESGVGKEVFSRYIHTH
HHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
SKRSNKPFVAINMAAIPANLIESELFGFEKGAFTDANATKIGLFEMANEGTLFLDEIGEM
CCCCCCCEEEEEEHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHCCC
PYEIQAKLLRALQEKEITRLGSTKSIKIDVRIISATNANLDEKIKNGEFRSDLYYRLNTV
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHCCCCCCCCCEEEEEEE
PINIPPLRERKEEILGIAQKVLEDTCKEYDFKEKQLSQEAKNALLEYDFPGNIRELISVV
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCHHHHHHHH
QRACILSENDEISSEDLFLEARSIKKDVKNLEKELICEVLLSVDYDKDQASQILGMDIKI
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHH
LNEKIKKYQIKDK
HHHHHHHHCCCCC
>Mature Secondary Structure
MNLVIVEDDINMRKSLEIALAEYEEFNIKSYKSATEALKKIDENTDLIITDINMPGIDGI
CEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHH
EFVKACENKYDFIIMTGNATLSRAIEAVRLGVKDFLTKPFDVDTLVEAIKRAKIIREKTA
HHHHHHCCCCCEEEEECCHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DKKSKKNEKKEENKDFFSTSPNLEKTLNLSQKAAKTDASVMFFGESGVGKEVFSRYIHTH
HHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH
SKRSNKPFVAINMAAIPANLIESELFGFEKGAFTDANATKIGLFEMANEGTLFLDEIGEM
CCCCCCCEEEEEEHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHCCC
PYEIQAKLLRALQEKEITRLGSTKSIKIDVRIISATNANLDEKIKNGEFRSDLYYRLNTV
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHCCCCCCCCCEEEEEEE
PINIPPLRERKEEILGIAQKVLEDTCKEYDFKEKQLSQEAKNALLEYDFPGNIRELISVV
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCHHHHHHHH
QRACILSENDEISSEDLFLEARSIKKDVKNLEKELICEVLLSVDYDKDQASQILGMDIKI
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHH
LNEKIKKYQIKDK
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]