Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 57237669

GI number: 57237669

Start: 852998

End: 854209

Strand: Reverse

Name: ilvA [H]

Synonym: CJE0915

Alternate gene names: 57237669

Gene position: 854209-852998 (Counterclockwise)

Preceding gene: 57237670

Following gene: 57237661

Centisome position: 48.05

GC content: 33.99

Gene sequence:

>1212_bases
GTGTTAGAGCTTAATAAAATTTACAAAGCAAAACAACAAATTTCAGGGTTTGTAAACAAAACTCCTTTCATATACTCTTC
TTTTTTAAGTGATATTTGTCAAAGTGAGATTTATCTTAAAAATGAAAATTTACAAATTACAGGTGCTTATAAAATTCGTG
GAGCTTATAATAAAATAGCCAATCTTAGCGCTGAACAAAAACAACACGGAGTCATTGCGGCAAGTGCAGGAAACCATGCT
CAAGGCGTGGCCATTAGTGCAAAAAAATTTGGCATTAAAGCAGTTATTGTAATGCCAGAATCCACTCCGCTCTTAAAAGT
TTCTGCTACAAAAGCCTTAGGAGCAGAGGTGATACTCAAAGGAGACAATTTTGATGAAGCTTATGTCTTTGCAACCTCTT
ATGCTAAAGAAAATAATCTTAGTTTTATCCATCCTTTTGAAGATGAATTTGTAATGGCAGGACAAGGAACTTTGATGCTT
GAAATGCTTGATGAAATAAGCGATCTTGATATGATTATCGCACCTGTTGGAGGTGGAGGACTTATAAGTGGTATCGCAAG
TGCAGCTAAACAAATCAATCCAAACATTAAAATCATCGGAGTTGGAGCCAAAGGAGCTCCTGCAATGTATGAAAGTTTTC
ATGCCAAAAAAATCAAAAATGCAAAAAGCGTACGCACTATAGCCGATGGTATTGCTGTGCGTGATGCAAATCCTATTAAT
TTTAATATTATTTTAGAATGCGTAGATGATTTTATCCAAGTTGATGATGAAGAAATCGCTAATGCGGTATTGTTTTTACT
TGAAAAACATAAAATCATAGTTGAAGGCGCAGGAGCTGCGAGTGTAGCCACCCTACTTCATCAAAAAATAAATACACAAA
ATCATAAAAAAATTGGCGTAGTTTTAAGCGGAGGCAATATCGATGCACAAATGCTAAATATCATCATAGAAAAAGGTTTA
TTTAAATCCTACAGAAAAATGCAAATTCATGTTACTTTAGTAGATAAACCTGGGGCATTATTACACCTTACAGACAGCTT
AAAAATAGCCAATGCAAATATAGTAAAAATCGACTATGATAGATTTTCCACCAAGCTTGATTATGGCGATGCGATGATTT
CAATTACCCTAGAAACCAAAGGTAAAGAACATCAAGAAGAAATAAGAAAAATTTTAACCCAAAAGGCCTTTAATTTCTAT
GAAAGTTTTTAA

Upstream 100 bases:

>100_bases
ATGAAACAGCCAAAGAAGAATGTAAAAAATTAGATATAAATTTTATACAAAATCGTTGCATTATGCTAGAATATCCGTAT
TTTAAAACAAAGGAAAAATA

Downstream 100 bases:

>100_bases
TAACATATACGGCTTAAATAAAGCCCATTTGGCGGTGCTAAAAAGTGATTGTATTGCTTTTTGGCCTCAATCTGTTCTTT
GAGTTCTTTTTCACTCATTT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLELNKIYKAKQQISGFVNKTPFIYSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYVFATSYAKENNLSFIHPFEDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVATLLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF

Sequences:

>Translated_403_residues
MLELNKIYKAKQQISGFVNKTPFIYSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYVFATSYAKENNLSFIHPFEDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVATLLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF
>Mature_403_residues
MLELNKIYKAKQQISGFVNKTPFIYSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYVFATSYAKENNLSFIHPFEDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVATLLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=309, Percent_Identity=34.3042071197411, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI19923959, Length=296, Percent_Identity=27.3648648648649, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=27.0096463022508, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789505, Length=307, Percent_Identity=42.9967426710098, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=34.4736842105263, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1789235, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=38.8746803069054, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17537387, Length=390, Percent_Identity=34.3589743589744, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=28.0254777070064, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=39.6774193548387, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320930, Length=339, Percent_Identity=37.4631268436578, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=295, Percent_Identity=23.3898305084746, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355833, Length=389, Percent_Identity=33.9331619537275, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24645328, Length=305, Percent_Identity=31.1475409836066, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44037; Mature: 44037

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELNKIYKAKQQISGFVNKTPFIYSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCEEEEEEEEECCHHHHHH
NLSAEQKQHGVIAASAGNHAQGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILK
CCCCHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEE
GDNFDEAYVFATSYAKENNLSFIHPFEDEFVMAGQGTLMLEMLDEISDLDMIIAPVGGGG
CCCCCCEEEEEEECCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHCCCEEEEEECCCCH
LISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCC
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVATLLHQKINTQNHKKIGV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
VLSGGNIDAQMLNIIIEKGLFKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYD
EEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCEEEEEECCEEEECCEEEEEEHH
RFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFYESF
HHCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELNKIYKAKQQISGFVNKTPFIYSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCEEEEEEEEECCHHHHHH
NLSAEQKQHGVIAASAGNHAQGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILK
CCCCHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEE
GDNFDEAYVFATSYAKENNLSFIHPFEDEFVMAGQGTLMLEMLDEISDLDMIIAPVGGGG
CCCCCCEEEEEEECCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHCCCEEEEEECCCCH
LISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCC
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVATLLHQKINTQNHKKIGV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
VLSGGNIDAQMLNIIIEKGLFKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYD
EEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCEEEEEECCEEEECCEEEEEEHH
RFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFYESF
HHCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA