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The map label for this gene is serS [H]

Identifier: 57237444

GI number: 57237444

Start: 391965

End: 393200

Strand: Direct

Name: serS [H]

Synonym: CJE0438

Alternate gene names: 57237444

Gene position: 391965-393200 (Clockwise)

Preceding gene: 57237443

Following gene: 57237445

Centisome position: 22.05

GC content: 33.09

Gene sequence:

>1236_bases
ATGCTAGATTTAAAAAATTTGCAAAATAATTTTGATGAAGTGGCTAAAAAGTTAAAAAATAAAAAAGTTGATGAAAATAT
CTTAAAAAAACTTGCTGAACTTTTTGCAAGTTTAAAAAAAGAAAAAATAGCCTTGGAAGAATTTCAAGCTTTTCAAAATA
AATTCAGTAAAGAGCTTGCTACAGCCGAAGATAAAGAAAGTTTAAAAGCAAAATTAAGCGAAAATAAAAGCAAAATTAAT
GAGCAAAGCGCTAAAGTAAATGCTTTAGAAAATGAGCTTGAGGAAATCGCTCATGCCATCCCAAATATCCCTGATGAATG
TGTGCCTGTGGGTGAAGATGAAAATGAAAATGTGGAGCTTAAAAAAGTTTTAAATCCACCTAGCTTTGATTTTACTCCAA
AAGAACATTTTGAATTAGGCGAGAGTTTAAATTGGCTTGATTTTATACGTGGGGTAAAAATTTCACAAAGTCGTTTTTGT
GTGCTTAAAAATGAAGGAGCTTTATTAAGCCGTGCTTTGGTAAATTATATGATAGATTTTAATAGAAGTCGTGGATTTGA
ATTTGTTAATGTACCTTTTTTGGTAAATGGTGCTACTATGTTTGGGACGGGTCAGTTGCCAAAATTTAAAGAAGATATGT
ATAAGGTAGATGATGAGGATTTGTATTTGATCTCAACTTCTGAAATTCCAGTAACCAATCTTTACAGCGGAGAAATTTTA
GCGAGTGAAACTTTACCTATAAAAATGACTTGTTATAGTGCTTGTTTTAGAAAAGAAGCAGGCAGTGCAGGGCGTGATAC
AAGGGGTATTATAAGACAACACCAGTTTGAAAAAGTAGAGCTTGTAAGTATCACTAAAACTGAGCAAAGTGATAGTGTGT
TTAATGAAATGCTTGAGTGTGCAAGTGATTTGCTGAGTTCTTTAGGTTTAGCGCATAGACATTTGATGCTTTGCACTGGA
GATTTGGGTTTTAGTGCAGCAAAAACTGTAGATCTTGAAGTGTGGCTTCCAGGACAAAATAAATATCGTGAGATCAGCTC
GGTTTCAAATTGTCGTGATTTTCAAGCAAGACGCGCTAAAATTCGCTATAAAAACGAACAAGGAAAAAATGAACTCGTCC
ACACTCTTAATGGCTCATCTTTGGCAGTAGGAAGAACCTTGGTAGCGATTATGGAAAATTATCAAGATAAAGAAGGAAAA
ATTCATATTCCTGATGTTTTGAAAAAATATTTTTAA

Upstream 100 bases:

>100_bases
TTGAAAGAAATTTTGGATTTTGGTGCGACAAAAGCAAGAAAAATCGCCCAAGAAAAAATGCAAAAAATTTATGAAAAAAT
CGGACTTTAAGGAGTAGAAA

Downstream 100 bases:

>100_bases
AGAGTATAGATGGCTGAACAAGAAGATATAATACTAGAAAAACCCGAAGATGGCTTAAATCAACCAAGACTTGATGAGAG
TTTAGAGGGATTTAAAGGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKIALEEFQAFQNKFSKELATAEDKESLKAKLSENKSKIN
EQSAKVNALENELEEIAHAIPNIPDECVPVGEDENENVELKKVLNPPSFDFTPKEHFELGESLNWLDFIRGVKISQSRFC
VLKNEGALLSRALVNYMIDFNRSRGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEIL
ASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKTEQSDSVFNEMLECASDLLSSLGLAHRHLMLCTG
DLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAKIRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGK
IHIPDVLKKYF

Sequences:

>Translated_411_residues
MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKIALEEFQAFQNKFSKELATAEDKESLKAKLSENKSKIN
EQSAKVNALENELEEIAHAIPNIPDECVPVGEDENENVELKKVLNPPSFDFTPKEHFELGESLNWLDFIRGVKISQSRFC
VLKNEGALLSRALVNYMIDFNRSRGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEIL
ASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKTEQSDSVFNEMLECASDLLSSLGLAHRHLMLCTG
DLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAKIRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGK
IHIPDVLKKYF
>Mature_411_residues
MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKIALEEFQAFQNKFSKELATAEDKESLKAKLSENKSKIN
EQSAKVNALENELEEIAHAIPNIPDECVPVGEDENENVELKKVLNPPSFDFTPKEHFELGESLNWLDFIRGVKISQSRFC
VLKNEGALLSRALVNYMIDFNRSRGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEIL
ASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKTEQSDSVFNEMLECASDLLSSLGLAHRHLMLCTG
DLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAKIRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGK
IHIPDVLKKYF

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=392, Percent_Identity=33.9285714285714, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI225579074, Length=400, Percent_Identity=33.75, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI16306548, Length=397, Percent_Identity=35.7682619647355, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=47.3067915690867, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17539260, Length=350, Percent_Identity=33.1428571428571, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17542084, Length=350, Percent_Identity=29.7142857142857, Blast_Score=160, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=421, Percent_Identity=34.916864608076, Blast_Score=219, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=370, Percent_Identity=32.1621621621622, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=327, Percent_Identity=35.474006116208, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46570; Mature: 46570

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKIALEEFQAFQNKFSKELA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAEDKESLKAKLSENKSKINEQSAKVNALENELEEIAHAIPNIPDECVPVGEDENENVEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEH
KKVLNPPSFDFTPKEHFELGESLNWLDFIRGVKISQSRFCVLKNEGALLSRALVNYMIDF
HHHCCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHC
NRSRGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEIL
CCCCCCEEEECCEEEECCEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEEECCCCCEE
ASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKTEQSDSVFNEMLEC
ECCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHH
ASDLLSSLGLAHRHLMLCTGDLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAK
HHHHHHHHCHHHHEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGKIHIPDVLKKYF
HEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHCC
>Mature Secondary Structure
MLDLKNLQNNFDEVAKKLKNKKVDENILKKLAELFASLKKEKIALEEFQAFQNKFSKELA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAEDKESLKAKLSENKSKINEQSAKVNALENELEEIAHAIPNIPDECVPVGEDENENVEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEH
KKVLNPPSFDFTPKEHFELGESLNWLDFIRGVKISQSRFCVLKNEGALLSRALVNYMIDF
HHHCCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHC
NRSRGFEFVNVPFLVNGATMFGTGQLPKFKEDMYKVDDEDLYLISTSEIPVTNLYSGEIL
CCCCCCEEEECCEEEECCEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEEECCCCCEE
ASETLPIKMTCYSACFRKEAGSAGRDTRGIIRQHQFEKVELVSITKTEQSDSVFNEMLEC
ECCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHH
ASDLLSSLGLAHRHLMLCTGDLGFSAAKTVDLEVWLPGQNKYREISSVSNCRDFQARRAK
HHHHHHHHCHHHHEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRYKNEQGKNELVHTLNGSSLAVGRTLVAIMENYQDKEGKIHIPDVLKKYF
HEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA