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The map label for this gene is cmeC [H]

Identifier: 57237420

GI number: 57237420

Start: 368811

End: 370289

Strand: Reverse

Name: cmeC [H]

Synonym: CJE0414

Alternate gene names: 57237420

Gene position: 370289-368811 (Counterclockwise)

Preceding gene: 57237421

Following gene: 57237418

Centisome position: 20.83

GC content: 31.71

Gene sequence:

>1479_bases
ATGAATAAAATAATTTCAATTAGCGCTATAGCAAGTTTTACTCTTTTGATTTCAGCTTGCTCTTTAAGTCCAAATTTAAA
TATTCCCGAAGCAAACTATAGCATTGATAATAAGCTTGGAGCCTTATCCTGGGAAAAAGAAAACAATAGCTCTATCACAA
AAAATTGGTGGAAAGACTTTGATGATGAAAATTTAAATAAAGTGGTTGATTTAGCACTTAAAAATAATAATGATTTAAAA
CTTGCTTTCATACACATGGAACAAGCTGCTGCTCAATTAGGTATAGATTTTAGCAGTTTGTTGCCAAAATTTGATGGTAG
TGCAAGCGGAAGTCGTGCAAAAACAGCTATAAATGCTCCAAGCAATCGAACTGGGGAAGTAAGTTACGGTAATGATTTTA
AAATGGGACTTAATTTAAGCTATGAAATCGATCTTTGGGGAAAATATCGCGATACATATCGCGCCTCAAAATCAGGCTTT
AAAGCAAGTGAGTATGATTATGAAGCTGCAAGACTTTCTGTTATTTCAAATACAGTTCAAACTTATTTTAATCTTGCAAA
TGCTTATGAAAATGAAAATGCTCTTAAAGAAACCTATGAATCGGCAAAAGAAATTTATAGGATTAATGATGAAAAATTTC
AAGTTGGTGCTGTAGGTGAATATGAACTTGCTCAAGCAAGAGCCAACTTAGAAAGTATGGCTTTGCAATATAATGAAGCA
AAGTTAAATAAAGAAAATTACCTTAAAGCTTTAAAAATTTTAACTTCAAATGATTTAAATGACATACTTTACAAAAATCA
AAGCTATCAAGTTTTTAATCTTAAAGAATTTGACATTCCAACTGGAATTTCAAGTACCATCTTGCTTCAACGTCCAGATA
TTGGCTCTTCTTTAGAAAAATTAACTCAGCAAAATTATCTTGTTGGAGTAGCCCGCACGGCTTTCTTACCTAGCCTTTCT
TTAACAGGATTATTGGGATTTGAAAGTGGGGATTTAGATACCTTGGTTAAAGGAGGTTCTAAGACTTGGAATATAGGTGG
AAACTTTACTCTGCCTATTTTTCATTGGGGTGAAATTTACCAAAATGTAAATTTAGCTAAGCTTAATAAAGATGAAGCTT
TTGTAAATTATCAAAATACTTTGATTACTGCTTTTGGAGAAATTCGCTATGCTTTAGTAGCTAGAAAAACTATACGCTTA
CAATACGATAATGCACAAGCAAGCGAACAATCTTACAAAAGAATCTATGAAATTGCTAAAGAACGCTATGATATAGGAGA
AATGTCTTTGCAAGATTATTTAGAAGCACGTCAAAATTGGCTTAATGCTGCCGTTGCTTTTAATAATACTAAATATTCTT
ATGCCAATTCCATAGTAGATGTAATCAAAGCATTTGGTGGAGGATTTGAGCAAAGTGAAGATACGAGTAAAAATATAAAA
GAAGAATCAAAAAATTTAGATATGTCTTTTAGAGAATAG

Upstream 100 bases:

>100_bases
ATGATCGCAGCATCAACTTTAGCGATATTCTTTGTGCCTTTATTTTTCTATCTTTTAGAAAATTTTAATGAATGGCTAGA
TAAAAAAAGAGGTAAGGTTC

Downstream 100 bases:

>100_bases
TTTGTTCTATTCTCTAAATAAATTAAAAATCTTTGTCTAAATCTGCATCTGTAATTTCATAAGCCTTGTAAATAGCAGGC
AATAATTTTCTTATAGCATA

Product: RND efflux system, outer membrane lipoprotein CmeC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDFDDENLNKVVDLALKNNNDLK
LAFIHMEQAAAQLGIDFSSLLPKFDGSASGSRAKTAINAPSNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSGF
KASEYDYEAARLSVISNTVQTYFNLANAYENENALKETYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEA
KLNKENYLKALKILTSNDLNDILYKNQSYQVFNLKEFDIPTGISSTILLQRPDIGSSLEKLTQQNYLVGVARTAFLPSLS
LTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIYQNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRL
QYDNAQASEQSYKRIYEIAKERYDIGEMSLQDYLEARQNWLNAAVAFNNTKYSYANSIVDVIKAFGGGFEQSEDTSKNIK
EESKNLDMSFRE

Sequences:

>Translated_492_residues
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDFDDENLNKVVDLALKNNNDLK
LAFIHMEQAAAQLGIDFSSLLPKFDGSASGSRAKTAINAPSNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSGF
KASEYDYEAARLSVISNTVQTYFNLANAYENENALKETYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEA
KLNKENYLKALKILTSNDLNDILYKNQSYQVFNLKEFDIPTGISSTILLQRPDIGSSLEKLTQQNYLVGVARTAFLPSLS
LTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIYQNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRL
QYDNAQASEQSYKRIYEIAKERYDIGEMSLQDYLEARQNWLNAAVAFNNTKYSYANSIVDVIKAFGGGFEQSEDTSKNIK
EESKNLDMSFRE
>Mature_492_residues
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDFDDENLNKVVDLALKNNNDLK
LAFIHMEQAAAQLGIDFSSLLPKFDGSASGSRAKTAINAPSNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSGF
KASEYDYEAARLSVISNTVQTYFNLANAYENENALKETYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEA
KLNKENYLKALKILTSNDLNDILYKNQSYQVFNLKEFDIPTGISSTILLQRPDIGSSLEKLTQQNYLVGVARTAFLPSLS
LTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIYQNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRL
QYDNAQASEQSYKRIYEIAKERYDIGEMSLQDYLEARQNWLNAAVAFNNTKYSYANSIVDVIKAFGGGFEQSEDTSKNIK
EESKNLDMSFRE

Specific function: The outer membrane component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solven

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=456, Percent_Identity=27.1929824561404, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI2367348, Length=493, Percent_Identity=22.5152129817444, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55409; Mature: 55409

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDF
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCC
DDENLNKVVDLALKNNNDLKLAFIHMEQAAAQLGIDFSSLLPKFDGSASGSRAKTAINAP
CCCCHHHHEEEEEECCCCEEEEEEEHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEECCC
SNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSGFKASEYDYEAARLSVISNTVQ
CCCCCCEECCCCEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TYFNLANAYENENALKETYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEA
HHHHHHHHHCCCHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHH
KLNKENYLKALKILTSNDLNDILYKNQSYQVFNLKEFDIPTGISSTILLQRPDIGSSLEK
HCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHH
LTQQNYLVGVARTAFLPSLSLTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIY
HHHCCCEEEEHHHHHCCCCCEEEEEECCCCCHHHHHCCCCEEEECCCCEEEEEEEHHHHH
QNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRLQYDNAQASEQSYKRIYEIAK
CCCCEEEECCCCCEEEECHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHH
ERYDIGEMSLQDYLEARQNWLNAAVAFNNTKYSYANSIVDVIKAFGGGFEQSEDTSKNIK
HHCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
EESKNLDMSFRE
HHHHCCCCCCCC
>Mature Secondary Structure
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDF
CCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCC
DDENLNKVVDLALKNNNDLKLAFIHMEQAAAQLGIDFSSLLPKFDGSASGSRAKTAINAP
CCCCHHHHEEEEEECCCCEEEEEEEHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEECCC
SNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSGFKASEYDYEAARLSVISNTVQ
CCCCCCEECCCCEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TYFNLANAYENENALKETYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEA
HHHHHHHHHCCCHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHH
KLNKENYLKALKILTSNDLNDILYKNQSYQVFNLKEFDIPTGISSTILLQRPDIGSSLEK
HCCHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHH
LTQQNYLVGVARTAFLPSLSLTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIY
HHHCCCEEEEHHHHHCCCCCEEEEEECCCCCHHHHHCCCCEEEECCCCEEEEEEEHHHHH
QNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRLQYDNAQASEQSYKRIYEIAK
CCCCEEEECCCCCEEEECHHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHHHHHHH
ERYDIGEMSLQDYLEARQNWLNAAVAFNNTKYSYANSIVDVIKAFGGGFEQSEDTSKNIK
HHCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
EESKNLDMSFRE
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]