Click here to switch to the map view.

The map label for this gene is bioF [C]

Identifier: 57237357

GI number: 57237357

Start: 314054

End: 315196

Strand: Reverse

Name: bioF [C]

Synonym: CJE0351

Alternate gene names: 57237357

Gene position: 315196-314054 (Counterclockwise)

Preceding gene: 57237359

Following gene: 57237356

Centisome position: 17.73

GC content: 30.27

Gene sequence:

>1143_bases
ATGAGCCTTGAAAATATCTTAGAAGCCCTTGAAAAAAATCACAATCTTAGAAAACTTACAAGCCTCAAACATGAAGGAAA
TTTTGTTTTTAAAGAGGGTAAAAAGCTTTTAAATTTAGCGGGGAATGATTATTTAAATTTAAGCTCTTGCAAATCTTTAA
AAGATGAATTTTTAGATAATGTCAAAGAACAAGACTTATTTTTTTCAAGCTCAAGTTCAAGGAGCTTGAGTGGAAATTTT
ACAATTTATGAGGAATTAGAAAGCTTTTTAAAATCCAAATTTAAAGAAAAAGAAATCTTACATTTTAACAGCGGTTATCA
TCTTAATATCTCTTGTATAGCTGCACTTGTGAGCATTCCAAATACACTTTTTTTAGTAGATAAATTCATCCATGCAAGTA
TGATTGATGGACTAAAACTTGGCGGAGCAAAATTTTTTCGCTTTCATCATAACGATATGAATCATTTAGAAAATTTAATT
CAAAAACATTATGATCATTATGAAAATATCATCATTTTAAGCGAAGCATTATTTAGCATGGATGGTGATTTTTCTGATTT
TAATACACTCATCGCCTTTAAAGAAAAATACCCTAAAATCAAACTTTATATCGATGAAGCGCACAGCGTGGGTTGCTTTG
ATGAGGAGGGCTTGGGACTTGTTAAAGCTTTAAATTTGGAAGAAAAGGTTGATTTTATAGTTTTTACCTTTGGCAAGGCT
CTTGCTTCTATGGGTGCTTGCATGATTTGTAATAATCTTTATAAAAGCTTTTTTATCAACAAAGCTAGAGCTTTTATTTA
TTCTACAGCGCTGCCTCCTATCAATATAGCTTGGACAAAATTTATTTTTGAAAAAATGAGCGAGCTAAAAGAAAAAAGAG
AAAAATTACAAATCATAGGCAACTTTTTTAAAAATCAACTCATAGAAAAAAATCATCAAATTTTAGGCGATGCTTACATC
ATCTCCTTGGTTTTGGGAGAAAATCAAAAGACTATAGAATTAGCAAAAAAACTTGAAACAAATGGCATTTTTGCACCCGC
TATAAAAGAACCTACGGTGCCTAAAAATACAGCTAGAATTCGTTTTTCTTTGCATGCAGGACTTAGTAAAGAAGATTTAA
AGAAAGTGATAGAACTTTTATGA

Upstream 100 bases:

>100_bases
CTAAATCGAGTTTTTTTAAAATTTCATTTTGCATTATAACTTCTTTTTTAAATATATTTTGGCAAAATAATACTTTAAAT
TTCTGAATTTTAGGAAAAAA

Downstream 100 bases:

>100_bases
AAATAAGCAATTTAATTCAAAATGAAAACTCACAAGAACTTATCTTAGTATTTGGCGGTTTTGCTTCACATCCTAGCCAT
TTTGCACATTTAAAAAGCGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSLENILEALEKNHNLRKLTSLKHEGNFVFKEGKKLLNLAGNDYLNLSSCKSLKDEFLDNVKEQDLFFSSSSSRSLSGNF
TIYEELESFLKSKFKEKEILHFNSGYHLNISCIAALVSIPNTLFLVDKFIHASMIDGLKLGGAKFFRFHHNDMNHLENLI
QKHYDHYENIIILSEALFSMDGDFSDFNTLIAFKEKYPKIKLYIDEAHSVGCFDEEGLGLVKALNLEEKVDFIVFTFGKA
LASMGACMICNNLYKSFFINKARAFIYSTALPPINIAWTKFIFEKMSELKEKREKLQIIGNFFKNQLIEKNHQILGDAYI
ISLVLGENQKTIELAKKLETNGIFAPAIKEPTVPKNTARIRFSLHAGLSKEDLKKVIELL

Sequences:

>Translated_380_residues
MSLENILEALEKNHNLRKLTSLKHEGNFVFKEGKKLLNLAGNDYLNLSSCKSLKDEFLDNVKEQDLFFSSSSSRSLSGNF
TIYEELESFLKSKFKEKEILHFNSGYHLNISCIAALVSIPNTLFLVDKFIHASMIDGLKLGGAKFFRFHHNDMNHLENLI
QKHYDHYENIIILSEALFSMDGDFSDFNTLIAFKEKYPKIKLYIDEAHSVGCFDEEGLGLVKALNLEEKVDFIVFTFGKA
LASMGACMICNNLYKSFFINKARAFIYSTALPPINIAWTKFIFEKMSELKEKREKLQIIGNFFKNQLIEKNHQILGDAYI
ISLVLGENQKTIELAKKLETNGIFAPAIKEPTVPKNTARIRFSLHAGLSKEDLKKVIELL
>Mature_379_residues
SLENILEALEKNHNLRKLTSLKHEGNFVFKEGKKLLNLAGNDYLNLSSCKSLKDEFLDNVKEQDLFFSSSSSRSLSGNFT
IYEELESFLKSKFKEKEILHFNSGYHLNISCIAALVSIPNTLFLVDKFIHASMIDGLKLGGAKFFRFHHNDMNHLENLIQ
KHYDHYENIIILSEALFSMDGDFSDFNTLIAFKEKYPKIKLYIDEAHSVGCFDEEGLGLVKALNLEEKVDFIVFTFGKAL
ASMGACMICNNLYKSFFINKARAFIYSTALPPINIAWTKFIFEKMSELKEKREKLQIIGNFFKNQLIEKNHQILGDAYII
SLVLGENQKTIELAKKLETNGIFAPAIKEPTVPKNTARIRFSLHAGLSKEDLKKVIELL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=388, Percent_Identity=26.2886597938144, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=27.1676300578035, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4758668, Length=395, Percent_Identity=27.8481012658228, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=26.5027322404372, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4502025, Length=335, Percent_Identity=25.3731343283582, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI40316939, Length=335, Percent_Identity=25.3731343283582, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=25.78125, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=28.133704735376, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790046, Length=364, Percent_Identity=24.7252747252747, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71994529, Length=349, Percent_Identity=26.9340974212034, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=24.7956403269755, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=391, Percent_Identity=24.5524296675192, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17560914, Length=391, Percent_Identity=24.5524296675192, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=25.7692307692308, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71982625, Length=260, Percent_Identity=25.7692307692308, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=26.8698060941828, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=366, Percent_Identity=24.8633879781421, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=23.1617647058824, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662918, Length=366, Percent_Identity=26.5027322404372, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=27.9452054794521, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137420, Length=359, Percent_Identity=26.7409470752089, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653280, Length=282, Percent_Identity=21.9858156028369, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653276, Length=282, Percent_Identity=21.9858156028369, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653278, Length=282, Percent_Identity=21.9858156028369, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43420; Mature: 43289

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLENILEALEKNHNLRKLTSLKHEGNFVFKEGKKLLNLAGNDYLNLSSCKSLKDEFLDN
CCHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHC
VKEQDLFFSSSSSRSLSGNFTIYEELESFLKSKFKEKEILHFNSGYHLNISCIAALVSIP
HHHHHEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHHCC
NTLFLVDKFIHASMIDGLKLGGAKFFRFHHNDMNHLENLIQKHYDHYENIIILSEALFSM
CHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEHHHHHHC
DGDFSDFNTLIAFKEKYPKIKLYIDEAHSVGCFDEEGLGLVKALNLEEKVDFIVFTFGKA
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHCEEEEHHHHH
LASMGACMICNNLYKSFFINKARAFIYSTALPPINIAWTKFIFEKMSELKEKREKLQIIG
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NFFKNQLIEKNHQILGDAYIISLVLGENQKTIELAKKLETNGIFAPAIKEPTVPKNTARI
HHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEE
RFSLHAGLSKEDLKKVIELL
EEEEECCCCHHHHHHHHHHC
>Mature Secondary Structure 
SLENILEALEKNHNLRKLTSLKHEGNFVFKEGKKLLNLAGNDYLNLSSCKSLKDEFLDN
CHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHC
VKEQDLFFSSSSSRSLSGNFTIYEELESFLKSKFKEKEILHFNSGYHLNISCIAALVSIP
HHHHHEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHHCC
NTLFLVDKFIHASMIDGLKLGGAKFFRFHHNDMNHLENLIQKHYDHYENIIILSEALFSM
CHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEHHHHHHC
DGDFSDFNTLIAFKEKYPKIKLYIDEAHSVGCFDEEGLGLVKALNLEEKVDFIVFTFGKA
CCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHCEEEEHHHHH
LASMGACMICNNLYKSFFINKARAFIYSTALPPINIAWTKFIFEKMSELKEKREKLQIIG
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NFFKNQLIEKNHQILGDAYIISLVLGENQKTIELAKKLETNGIFAPAIKEPTVPKNTARI
HHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEE
RFSLHAGLSKEDLKKVIELL
EEEEECCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA