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The map label for this gene is hom [H]

Identifier: 57237157

GI number: 57237157

Start: 151181

End: 152428

Strand: Reverse

Name: hom [H]

Synonym: CJE0145

Alternate gene names: 57237157

Gene position: 152428-151181 (Counterclockwise)

Preceding gene: 57237158

Following gene: 57237156

Centisome position: 8.57

GC content: 31.49

Gene sequence:

>1248_bases
ATGAAAGTAGCGATTCTTGGTTATGGCACTGTTGGAAGTGCGGTGGTTAAATTTCTTTTAGAAAATGATAAACTCATTCG
TGCAAGATGTGGGCAAAGCATAACTCCTGTGATCGCTCTTGCTAGAAGTCCTAAAAAAAATGCTTTAATTCCAATTACTC
ATAGCGTTGCAGAAATTTTAAATGCTGATGTAGATGTTTTTGTAGAATTAATGGGTGGGGTGGATGAAGCTTTTAAAATA
GTGAGTGAAATTTTAAAAAAGAAAAAAGCTGTTGTTACTGCAAATAAAGCTATGCTTGCTTATCATCGTTATGAACTTGA
AAATTTGGCTAAAAATTTAGCTTTTGGTTATGAAGCAAGTGTGGCTGGAGGAATTCCTATTATCAAGGTTTTAAAAGAAG
GTTTAAGTGCAAATAATATTTTGGCTATAAAAGGGATTTTAAATGGTACGAGTAATTATATTTTAAGTTCTATGAGTCAA
AAAAATATGAGTTTTAAACAAGCTTTGCAAATAGCTCAAAATTTAGGTTATGCAGAGGCTGATCCAACTTTTGACATAGA
AGGGCAAGATGCAGCACATAAACTGCTTGTTTTATCAAGTATCGCTTATAATCTTAAAGCTAAACCTGAAGATATTTTGA
TCGAGGGTATTAGTGAAATTGCACCTGAAGATATGTATTTTGCTAATGAGTTTGAATTTACCATAAAACTTTTAGGTATA
GCTAAGGTGCGTGAAAATAAAGTAGAATTAAGGGTGCATCCTACTATGATAGATAAAGAAAAAATGCTTGCAAAAGTTGA
TGGAGTGATGAATGCTATAAGCATTAATGGAGATTTGTTGGGTGAAAGTTTGTATTATGGAGCAGGAGCAGGAGGAGAGG
CCACTGCAAGTGCTGTGATTTCAGATCTTATGGATATAGCAAGAGATCAGGTAAAAGCACCAATGCTTGGTTTTGTGAAT
ACTTTAGAATACAAGCTTTTAAGCAAAGATGAAATTTATACAAAATATTATTTAAGGGTGAAAGTTGAAGATAAAATAGG
GATTTTATCTAAAATCACACAATTGATGAGTGAAAATAATATTTCTATCGATAGTTTTTTACAAAAACCTAAAAAAAATG
ATGAAAATTACAGCACTTTGTTTTTTACTACACATTTAACTTATGAAAAAAGCATACAAAATTTGCTTGAAATTTTACGC
AAACAAGATTTTATAAAAACCAAGCCTTTTATGATGCGTATAGAATAA

Upstream 100 bases:

>100_bases
CGAAGCAGGTGATGAGTATGTAAGAATTGCTTTAATTGAAAATGAAAATCGCATACGCCAAGCTGCACGTAATATCAAAA
AATATTTAAAAGAGTAAGTT

Downstream 100 bases:

>100_bases
TGGGTGTAAAAGCTTATTTAGATGGAATTTTAGGGGAAGATAAGGCTTGTAAATTTTTAAAAAAACAAGGCTTTGAAATT
TTAAAAAGAAATTTCCATTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKVAILGYGTVGSAVVKFLLENDKLIRARCGQSITPVIALARSPKKNALIPITHSVAEILNADVDVFVELMGGVDEAFKI
VSEILKKKKAVVTANKAMLAYHRYELENLAKNLAFGYEASVAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMSQ
KNMSFKQALQIAQNLGYAEADPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISEIAPEDMYFANEFEFTIKLLGI
AKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDLLGESLYYGAGAGGEATASAVISDLMDIARDQVKAPMLGFVN
TLEYKLLSKDEIYTKYYLRVKVEDKIGILSKITQLMSENNISIDSFLQKPKKNDENYSTLFFTTHLTYEKSIQNLLEILR
KQDFIKTKPFMMRIE

Sequences:

>Translated_415_residues
MKVAILGYGTVGSAVVKFLLENDKLIRARCGQSITPVIALARSPKKNALIPITHSVAEILNADVDVFVELMGGVDEAFKI
VSEILKKKKAVVTANKAMLAYHRYELENLAKNLAFGYEASVAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMSQ
KNMSFKQALQIAQNLGYAEADPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISEIAPEDMYFANEFEFTIKLLGI
AKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDLLGESLYYGAGAGGEATASAVISDLMDIARDQVKAPMLGFVN
TLEYKLLSKDEIYTKYYLRVKVEDKIGILSKITQLMSENNISIDSFLQKPKKNDENYSTLFFTTHLTYEKSIQNLLEILR
KQDFIKTKPFMMRIE
>Mature_415_residues
MKVAILGYGTVGSAVVKFLLENDKLIRARCGQSITPVIALARSPKKNALIPITHSVAEILNADVDVFVELMGGVDEAFKI
VSEILKKKKAVVTANKAMLAYHRYELENLAKNLAFGYEASVAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMSQ
KNMSFKQALQIAQNLGYAEADPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISEIAPEDMYFANEFEFTIKLLGI
AKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDLLGESLYYGAGAGGEATASAVISDLMDIARDQVKAPMLGFVN
TLEYKLLSKDEIYTKYYLRVKVEDKIGILSKITQLMSENNISIDSFLQKPKKNDENYSTLFFTTHLTYEKSIQNLLEILR
KQDFIKTKPFMMRIE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=252, Percent_Identity=31.3492063492063, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=259, Percent_Identity=26.6409266409266, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45919; Mature: 45919

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAILGYGTVGSAVVKFLLENDKLIRARCGQSITPVIALARSPKKNALIPITHSVAEIL
CEEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHH
NADVDVFVELMGGVDEAFKIVSEILKKKKAVVTANKAMLAYHRYELENLAKNLAFGYEAS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCCC
VAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMSQKNMSFKQALQIAQNLGYAEA
CCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISEIAPEDMYFANEFEFTIKLLGI
CCCEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEEEH
AKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDLLGESLYYGAGAGGEATASAVI
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHEEECCCHHHCCHHEECCCCCCHHHHHHHH
SDLMDIARDQVKAPMLGFVNTLEYKLLSKDEIYTKYYLRVKVEDKIGILSKITQLMSENN
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCC
ISIDSFLQKPKKNDENYSTLFFTTHLTYEKSIQNLLEILRKQDFIKTKPFMMRIE
CCHHHHHCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
>Mature Secondary Structure
MKVAILGYGTVGSAVVKFLLENDKLIRARCGQSITPVIALARSPKKNALIPITHSVAEIL
CEEEEEECCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHH
NADVDVFVELMGGVDEAFKIVSEILKKKKAVVTANKAMLAYHRYELENLAKNLAFGYEAS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCCC
VAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMSQKNMSFKQALQIAQNLGYAEA
CCCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISEIAPEDMYFANEFEFTIKLLGI
CCCEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEEEH
AKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDLLGESLYYGAGAGGEATASAVI
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHEEECCCHHHCCHHEECCCCCCHHHHHHHH
SDLMDIARDQVKAPMLGFVNTLEYKLLSKDEIYTKYYLRVKVEDKIGILSKITQLMSENN
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHCCC
ISIDSFLQKPKKNDENYSTLFFTTHLTYEKSIQNLLEILRKQDFIKTKPFMMRIE
CCHHHHHCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]