Click here to switch to the map view.

The map label for this gene is ppiD [C]

Identifier: 57236997

GI number: 57236997

Start: 729782

End: 731272

Strand: Direct

Name: ppiD [C]

Synonym: CJE0793

Alternate gene names: 57236997

Gene position: 729782-731272 (Clockwise)

Preceding gene: 57236994

Following gene: 57236998

Centisome position: 41.05

GC content: 26.89

Gene sequence:

>1491_bases
ATGCTTACTTGGATGCAACATCACAAAAAATATCTTGTTGTTACTATATGGGTTAGTACTATAGCTTTTGTTGGCGCTGG
CTTTTTAGGTTGGGGTGCTTATGATTTTAATCTCAATAGAAGTTCGAGTGTTGCAACTGTAGGAAATGAAAAGATAGGTT
TTAGCGAATTTGATACTAGATATAGACAAATTTTAAGTTATTATAATCAAATTAGCAATGGTGCTTTAACTCCAGAAAAT
GCTGAGCAACTAGGCATTAAAAATATAGCTTTAAGCTCTCTTGTTGAAGATAAGCTTTTGTTAAATTTTGCCAAAGATTT
GGGTATTGGTGTAAACGAGAATGAAATTTTACAAAAACTTGCAAATACTAGAGAATTTCAAGATCCTACAGGGGATTTTA
ACAAAACAATTTATTATGAACTTTTAAATGCCAATAATTTAGCTCCAAAAGATTATGAAACACAACTTGCAAATGAAGTA
ATTACCGATAAACTTAATCAAATTTTTAATATTCCTAGCAAAGATGAGGAATTAAAAATGTTAGCTTCTAGTTATTTTAT
GCAAGATGCTTTAAGTATTGCAAAAATTGATTATGACAAAAAAAATATTAAGATTAACGAAGAGGATTTAAAAAAGCTTT
GGAATGAACATAAAGAAGATTATAAAACTAAAAAAATATATGAAATTTCAACTTATTTTTTGCCAGTTAGCAATGAGAAA
ATTGACGACAAAGAATTAGAAAAATTTTATAATCAAGATGAAAATAAACTAAAATATAAAGATTTTGCAGGTAAAGTGAT
GGATTTTCAGTCTGCTAAAAATGAAGTTGCTAAAGATTACGCCTTAATGCAACTAAAGAATGTGGCTAATGCTAAATTTT
TAGATTTAAAAAATGGGAAAGATAATTTTCAAAAAGATCAAAATATTAGTGAATCTGATGTTTATTATCCAATTGATCTT
TTGAGTAAAGCTAAAAATGGAGATGTTTTACGGCCAGCACCTTATAATAACGGATATATCATAGTTAAACTAAATAAAGT
AGATCCTATAAGAAATAAAACTTTTGAAGAAGCTAGAGAAGAAGTTTTACCTATGTATTTAAGCGAACAAACTAGAAAAA
ATTTAGAAGAAAAAGCTAAAAATAGTTTAGTAAATTTTAAAGGCGATGATATAGGCTTTGTAAGTCGAGATAGTTCTCGC
GAGAGTGTAAAGGTTAGCGATAAAATATTAAACGATTCTGAATTTGCTTATTTTTTAATGAATGTATTTAATACTGATCA
AAATAGTTCTTATGTGGTCATTAATGACAATAAAGCAATATTATATAAAATAAATAAACAAAAATTAGATATGAACTCCG
ATAAATTTGAACAATACAAAACTATGCTTGAACAAAATTTGCAAAATTTAAAAGCAAATGAGCTTAAGCAAGAACTTGTT
GATGAACTTAAAAAGATATATCCGATAAAAATTTATTATAAAGGGAATTGA

Upstream 100 bases:

>100_bases
ATTTAAAGAACAAATATTTTTTGGTAAAAATTTTATAATTAAACTCCACTTAAACACTTCTACGATACAATATCTGGTTT
AAATTTAATCAAGGAATGAT

Downstream 100 bases:

>100_bases
TTTTGAATATATTAGGAATTGACTTAGGCTCAACCCAGACTTGTGCCATTATTGCTCAAAAAGATGAAGATGGATTAAAA
ATTATTGGTTTTTCCAAGTC

Product: peptidyl-prolyl cis-trans isomerase D,-like protein

Products: peptidylproline (omega=0) [C]

Alternate protein names: None

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLTWMQHHKKYLVVTIWVSTIAFVGAGFLGWGAYDFNLNRSSSVATVGNEKIGFSEFDTRYRQILSYYNQISNGALTPEN
AEQLGIKNIALSSLVEDKLLLNFAKDLGIGVNENEILQKLANTREFQDPTGDFNKTIYYELLNANNLAPKDYETQLANEV
ITDKLNQIFNIPSKDEELKMLASSYFMQDALSIAKIDYDKKNIKINEEDLKKLWNEHKEDYKTKKIYEISTYFLPVSNEK
IDDKELEKFYNQDENKLKYKDFAGKVMDFQSAKNEVAKDYALMQLKNVANAKFLDLKNGKDNFQKDQNISESDVYYPIDL
LSKAKNGDVLRPAPYNNGYIIVKLNKVDPIRNKTFEEAREEVLPMYLSEQTRKNLEEKAKNSLVNFKGDDIGFVSRDSSR
ESVKVSDKILNDSEFAYFLMNVFNTDQNSSYVVINDNKAILYKINKQKLDMNSDKFEQYKTMLEQNLQNLKANELKQELV
DELKKIYPIKIYYKGN

Sequences:

>Translated_496_residues
MLTWMQHHKKYLVVTIWVSTIAFVGAGFLGWGAYDFNLNRSSSVATVGNEKIGFSEFDTRYRQILSYYNQISNGALTPEN
AEQLGIKNIALSSLVEDKLLLNFAKDLGIGVNENEILQKLANTREFQDPTGDFNKTIYYELLNANNLAPKDYETQLANEV
ITDKLNQIFNIPSKDEELKMLASSYFMQDALSIAKIDYDKKNIKINEEDLKKLWNEHKEDYKTKKIYEISTYFLPVSNEK
IDDKELEKFYNQDENKLKYKDFAGKVMDFQSAKNEVAKDYALMQLKNVANAKFLDLKNGKDNFQKDQNISESDVYYPIDL
LSKAKNGDVLRPAPYNNGYIIVKLNKVDPIRNKTFEEAREEVLPMYLSEQTRKNLEEKAKNSLVNFKGDDIGFVSRDSSR
ESVKVSDKILNDSEFAYFLMNVFNTDQNSSYVVINDNKAILYKINKQKLDMNSDKFEQYKTMLEQNLQNLKANELKQELV
DELKKIYPIKIYYKGN
>Mature_496_residues
MLTWMQHHKKYLVVTIWVSTIAFVGAGFLGWGAYDFNLNRSSSVATVGNEKIGFSEFDTRYRQILSYYNQISNGALTPEN
AEQLGIKNIALSSLVEDKLLLNFAKDLGIGVNENEILQKLANTREFQDPTGDFNKTIYYELLNANNLAPKDYETQLANEV
ITDKLNQIFNIPSKDEELKMLASSYFMQDALSIAKIDYDKKNIKINEEDLKKLWNEHKEDYKTKKIYEISTYFLPVSNEK
IDDKELEKFYNQDENKLKYKDFAGKVMDFQSAKNEVAKDYALMQLKNVANAKFLDLKNGKDNFQKDQNISESDVYYPIDL
LSKAKNGDVLRPAPYNNGYIIVKLNKVDPIRNKTFEEAREEVLPMYLSEQTRKNLEEKAKNSLVNFKGDDIGFVSRDSSR
ESVKVSDKILNDSEFAYFLMNVFNTDQNSSYVVINDNKAILYKINKQKLDMNSDKFEQYKTMLEQNLQNLKANELKQELV
DELKKIYPIKIYYKGN

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786645, Length=443, Percent_Identity=20.7674943566591, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 57512; Mature: 57512

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTWMQHHKKYLVVTIWVSTIAFVGAGFLGWGAYDFNLNRSSSVATVGNEKIGFSEFDTR
CCCHHHHCCCEEEEEEHHHHHHHHHCCHHHCCEEEECCCCCCCEEECCCCCCCCHHHHHH
YRQILSYYNQISNGALTPENAEQLGIKNIALSSLVEDKLLLNFAKDLGIGVNENEILQKL
HHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ANTREFQDPTGDFNKTIYYELLNANNLAPKDYETQLANEVITDKLNQIFNIPSKDEELKM
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LASSYFMQDALSIAKIDYDKKNIKINEEDLKKLWNEHKEDYKTKKIYEISTYFLPVSNEK
HHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCC
IDDKELEKFYNQDENKLKYKDFAGKVMDFQSAKNEVAKDYALMQLKNVANAKFLDLKNGK
CCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DNFQKDQNISESDVYYPIDLLSKAKNGDVLRPAPYNNGYIIVKLNKVDPIRNKTFEEARE
CHHHHCCCCCCCCCEEEHHHHHCCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHH
EVLPMYLSEQTRKNLEEKAKNSLVNFKGDDIGFVSRDSSRESVKVSDKILNDSEFAYFLM
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEECCCCCCCEEHHHHHCCCCHHHHHHH
NVFNTDQNSSYVVINDNKAILYKINKQKLDMNSDKFEQYKTMLEQNLQNLKANELKQELV
HHHCCCCCCCEEEEECCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DELKKIYPIKIYYKGN
HHHHHHCEEEEEECCC
>Mature Secondary Structure
MLTWMQHHKKYLVVTIWVSTIAFVGAGFLGWGAYDFNLNRSSSVATVGNEKIGFSEFDTR
CCCHHHHCCCEEEEEEHHHHHHHHHCCHHHCCEEEECCCCCCCEEECCCCCCCCHHHHHH
YRQILSYYNQISNGALTPENAEQLGIKNIALSSLVEDKLLLNFAKDLGIGVNENEILQKL
HHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ANTREFQDPTGDFNKTIYYELLNANNLAPKDYETQLANEVITDKLNQIFNIPSKDEELKM
HHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LASSYFMQDALSIAKIDYDKKNIKINEEDLKKLWNEHKEDYKTKKIYEISTYFLPVSNEK
HHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCC
IDDKELEKFYNQDENKLKYKDFAGKVMDFQSAKNEVAKDYALMQLKNVANAKFLDLKNGK
CCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
DNFQKDQNISESDVYYPIDLLSKAKNGDVLRPAPYNNGYIIVKLNKVDPIRNKTFEEARE
CHHHHCCCCCCCCCEEEHHHHHCCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHH
EVLPMYLSEQTRKNLEEKAKNSLVNFKGDDIGFVSRDSSRESVKVSDKILNDSEFAYFLM
HHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEECCCCCCCEEHHHHHCCCCHHHHHHH
NVFNTDQNSSYVVINDNKAILYKINKQKLDMNSDKFEQYKTMLEQNLQNLKANELKQELV
HHHCCCCCCCEEEEECCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DELKKIYPIKIYYKGN
HHHHHHCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA