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The map label for this gene is gmhB [H]

Identifier: 57235025

GI number: 57235025

Start: 194508

End: 195740

Strand: Direct

Name: gmhB [H]

Synonym: DET0202

Alternate gene names: 57235025

Gene position: 194508-195740 (Clockwise)

Preceding gene: 57235027

Following gene: 57235024

Centisome position: 13.23

GC content: 51.5

Gene sequence:

>1233_bases
ATGAACCAAAAGGCTGTATTTATTGACCGTGACGGCACAATTGTAGAAGACGTGCCGTATTGCAATTCCCCTAGAAAGAT
ACGCTTGCTGGAAGGGGCGGGCAAAGCTATTAGACGATTGAATGACCAGGGCTTCCTGGTCATTTTGATTACAAACCAGT
CCGGGGTTGCCAGAGGCTATTTTTCGGAAGAGACTTTAGGCGAAATCCACAACAAGCTCAAAGAAGATTTGGGCTATTTC
GGTGCTCATTTGGATGATATTTTTTACTGTCCGCATCACCCTGCCCAGAGTTGCACCTGCCGTAAACCGGCCACCGGCCT
TATTGACCAGGCAGTTGCAAAATACGGCCTGGATATCAGCGGTTCATACTTTATAGGTGACCGGCTGATAGATATTCAGG
CGGCCAACCGTTCAGGCTGCCAGGCGGTGCTGGTGCCGTATACTTTGCCCGAAACAGATTATTTTAAGCTGGAAATTTCT
GTTGACAGCCGCCCCTCTTTTCTGGCAGGTGATATTTCAGCCGCGGTGGATTGGGTGCTGGCGGATGCACTGGGCAAGGC
GTCTGTTTCGGTAGTTATACCCACCCTGAATGAAGAAAAAAATATCTGCAGTGTTCTGCCCCGCTTAAGGTGCGTGCCGG
GTATTGCCGAAGTTATTTTGGTGGACGGCAGGTCTACTGATAAAACTGTTGAAAATGCCCTGCGGCTATGGCCGGAAATA
AAGGTCATAAATCAGCCTGGCCGGGGTAAGGGTGATGCCATGCGGGCGGGTTTTGAAGCTGCTTGCGGGGATATAGTGGT
TACTCTGGATGCAGACGGGTCACTGGCTCCGGAGGAGATTCCCTGCTATGTGGGGCCTCTGTTTGACGGGTATCAGATGG
TCAAAGGTTCGCGCTTCTGCCGGGGCGGTGGCACTTCGGATATGCCGCTCTTCCGCCGTTTTGGCAATTTTGTCTTTACC
AAAATGGCTAATCTGGTGTGCGGCTGCCGTTATACAGACCTGGTTTACGGTTACCATGCCTTCCGCCGCCAGATACTGGG
AAGCCTGTGTTTGAAAAGTGACGGGTTTGAGATAGATACCGAAATGTATATCCGGGCCACCCGCAAGGGCTTGAAAGTAA
AGGAAGTACCCAGCTACGAAGCAAAAAGGCTGGAAGGGGCGGGTAAACTCCGCAGTTTCCATGATGGCGCCCGCATCTTG
CGGACTATACTGCGGGAGAGCGTTAATGGCTGA

Upstream 100 bases:

>100_bases
CCAAATGACCATGACAAAGCGTAATATTTAGGCAAAAACTATTGACAAATGGCACCTGATGGTCTTATTATAGTGACAAT
AAGCGAAAAACAGGGTACAA

Downstream 100 bases:

>100_bases
CCCGTTTATTTCGGTAGTGGTTTCAGCATACAGCATGGAGCGTTATACCGACCTGTTATCCCTCATAGACAGCCTTAAAT
CCCAGGCTTATACCAATTTT

Product: histidinol-phosphate phosphatase family protein/glycosyl transferase, group 2 family protein

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNQKAVFIDRDGTIVEDVPYCNSPRKIRLLEGAGKAIRRLNDQGFLVILITNQSGVARGYFSEETLGEIHNKLKEDLGYF
GAHLDDIFYCPHHPAQSCTCRKPATGLIDQAVAKYGLDISGSYFIGDRLIDIQAANRSGCQAVLVPYTLPETDYFKLEIS
VDSRPSFLAGDISAAVDWVLADALGKASVSVVIPTLNEEKNICSVLPRLRCVPGIAEVILVDGRSTDKTVENALRLWPEI
KVINQPGRGKGDAMRAGFEAACGDIVVTLDADGSLAPEEIPCYVGPLFDGYQMVKGSRFCRGGGTSDMPLFRRFGNFVFT
KMANLVCGCRYTDLVYGYHAFRRQILGSLCLKSDGFEIDTEMYIRATRKGLKVKEVPSYEAKRLEGAGKLRSFHDGARIL
RTILRESVNG

Sequences:

>Translated_410_residues
MNQKAVFIDRDGTIVEDVPYCNSPRKIRLLEGAGKAIRRLNDQGFLVILITNQSGVARGYFSEETLGEIHNKLKEDLGYF
GAHLDDIFYCPHHPAQSCTCRKPATGLIDQAVAKYGLDISGSYFIGDRLIDIQAANRSGCQAVLVPYTLPETDYFKLEIS
VDSRPSFLAGDISAAVDWVLADALGKASVSVVIPTLNEEKNICSVLPRLRCVPGIAEVILVDGRSTDKTVENALRLWPEI
KVINQPGRGKGDAMRAGFEAACGDIVVTLDADGSLAPEEIPCYVGPLFDGYQMVKGSRFCRGGGTSDMPLFRRFGNFVFT
KMANLVCGCRYTDLVYGYHAFRRQILGSLCLKSDGFEIDTEMYIRATRKGLKVKEVPSYEAKRLEGAGKLRSFHDGARIL
RTILRESVNG
>Mature_410_residues
MNQKAVFIDRDGTIVEDVPYCNSPRKIRLLEGAGKAIRRLNDQGFLVILITNQSGVARGYFSEETLGEIHNKLKEDLGYF
GAHLDDIFYCPHHPAQSCTCRKPATGLIDQAVAKYGLDISGSYFIGDRLIDIQAANRSGCQAVLVPYTLPETDYFKLEIS
VDSRPSFLAGDISAAVDWVLADALGKASVSVVIPTLNEEKNICSVLPRLRCVPGIAEVILVDGRSTDKTVENALRLWPEI
KVINQPGRGKGDAMRAGFEAACGDIVVTLDADGSLAPEEIPCYVGPLFDGYQMVKGSRFCRGGGTSDMPLFRRFGNFVFT
KMANLVCGCRYTDLVYGYHAFRRQILGSLCLKSDGFEIDTEMYIRATRKGLKVKEVPSYEAKRLEGAGKLRSFHDGARIL
RTILRESVNG

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0463

COG function: function code M; Glycosyltransferases involved in cell wall biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786399, Length=138, Percent_Identity=39.1304347826087, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082027, Length=142, Percent_Identity=34.5070422535211, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71999402, Length=215, Percent_Identity=32.093023255814, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585265, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: NA

Molecular weight: Translated: 45112; Mature: 45112

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKAVFIDRDGTIVEDVPYCNSPRKIRLLEGAGKAIRRLNDQGFLVILITNQSGVARGY
CCCCEEEEECCCCEEECCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCCCCCC
FSEETLGEIHNKLKEDLGYFGAHLDDIFYCPHHPAQSCTCRKPATGLIDQAVAKYGLDIS
CCHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GSYFIGDRLIDIQAANRSGCQAVLVPYTLPETDYFKLEISVDSRPSFLAGDISAAVDWVL
CCEEECCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEEECCCCCEEHHHHHHHHHHHH
ADALGKASVSVVIPTLNEEKNICSVLPRLRCVPGIAEVILVDGRSTDKTVENALRLWPEI
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCE
KVINQPGRGKGDAMRAGFEAACGDIVVTLDADGSLAPEEIPCYVGPLFDGYQMVKGSRFC
EEECCCCCCCCHHHHCCHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCEE
RGGGTSDMPLFRRFGNFVFTKMANLVCGCRYTDLVYGYHAFRRQILGSLCLKSDGFEIDT
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECH
EMYIRATRKGLKVKEVPSYEAKRLEGAGKLRSFHDGARILRTILRESVNG
HHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQKAVFIDRDGTIVEDVPYCNSPRKIRLLEGAGKAIRRLNDQGFLVILITNQSGVARGY
CCCCEEEEECCCCEEECCCCCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCCCCCC
FSEETLGEIHNKLKEDLGYFGAHLDDIFYCPHHPAQSCTCRKPATGLIDQAVAKYGLDIS
CCHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GSYFIGDRLIDIQAANRSGCQAVLVPYTLPETDYFKLEISVDSRPSFLAGDISAAVDWVL
CCEEECCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEEEECCCCCEEHHHHHHHHHHHH
ADALGKASVSVVIPTLNEEKNICSVLPRLRCVPGIAEVILVDGRSTDKTVENALRLWPEI
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCE
KVINQPGRGKGDAMRAGFEAACGDIVVTLDADGSLAPEEIPCYVGPLFDGYQMVKGSRFC
EEECCCCCCCCHHHHCCHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCEE
RGGGTSDMPLFRRFGNFVFTKMANLVCGCRYTDLVYGYHAFRRQILGSLCLKSDGFEIDT
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECH
EMYIRATRKGLKVKEVPSYEAKRLEGAGKLRSFHDGARILRTILRESVNG
HHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12101286 [H]