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The map label for this gene is yccK [H]

Identifier: 57234995

GI number: 57234995

Start: 210340

End: 211314

Strand: Direct

Name: yccK [H]

Synonym: DET0217

Alternate gene names: 57234995

Gene position: 210340-211314 (Clockwise)

Preceding gene: 57234996

Following gene: 57234993

Centisome position: 14.31

GC content: 50.67

Gene sequence:

>975_bases
ATGGATAATATTTTAGATAAGAAATGGGCTTACCGTGAACTTGGTCAAACGGGCATAGGGCTTAGTCCTTTGGGTTTGGG
CAGCTGGCAGTTCTCCCGCGGCAAGGGGGCGGCTATCGGTGTTTGGGGTATGCTGAACCAGGCCAAAGTAAATGAGATTG
TGCTTAATTCGCTTGCGGGCGGCATAAACTGGTTTGATACCGCCGAAGCTTATGGCATGGGGCAAAGCGAAGAGTCTCTG
GCCGAAGCTTTGAAGCAGGCGGGTATCCGGCCGGGTGAGTGTTTTATAGCTACCAAATGGCAGCCTACCATGCGCTCAGC
CTCTTCTCTGAAGACCCTTTTGCCCATACGTGAGGGCTTTCTAAGCCCGTATAAGGTAGATTTGTATCAGGTGCATTTCC
CGGGGCTTTTTGCCTCCATTGATGCCCAGATGGATAACATGGCCGCTTTGTATAAAGAAGGCCGGATACGGGCTATAGGC
GTCAGCAACTTTAATGCTTCCCAGATGCGTATTGCCCAGAAACGTTTAAACAAACACGGCCTGTCACTGGCTTCAAATCA
GGTCAAGTATAATCTGCTTGACCGGCAGATTGAGACAAACGGGGTGCTAGAGACTGCCCGCGAACTGGGTATCAGCCTGA
TTGCTTATTCTCCGCTGGCCATGGGTGTTCTTTCAGGTAAATACCAGCGTAATCCGGAGTATCTGGAGATGGTGCCTTTT
ATCCGCCGTAAAACTATCCGTCGCGCGCTGGAAAAGAGTATGCCGGTTATCGCCAAGCTCTCTGAAATATCTGCCAGGTA
CAATGCGGATATAGCTCAGGTAGCTTTGGCATGGGTAATTTACGGGCAGGGGGACACTGTTTTCGCTTTAGCCGGTGCCA
GTACCCCGGTGCAGGCACGTGAAAACCTTAGAGCCCTGGATATAAAACTGACCGCCGCTGAAATAGCTGAATTAAACAGT
GTTTCCGGGTCTTAG

Upstream 100 bases:

>100_bases
CAGTTTTGCTGGCGGCTTCGGGCTTGCCTTTGGCAGCCCCAGCGGCTAACATTTAGACGCGGTCTGTTAAGTATATAAAG
ATTATCGGGAGCGGCCGGAT

Downstream 100 bases:

>100_bases
GTTTGTCCGGGAGGGTCTGTTTGGGAAGGAGGTATTTGCCGCTGGCAGCAGGGACGGGCGTCCAGTTCGAAAACTCCCCC
CTCTATCCGCAGGGCTTTAC

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDNILDKKWAYRELGQTGIGLSPLGLGSWQFSRGKGAAIGVWGMLNQAKVNEIVLNSLAGGINWFDTAEAYGMGQSEESL
AEALKQAGIRPGECFIATKWQPTMRSASSLKTLLPIREGFLSPYKVDLYQVHFPGLFASIDAQMDNMAALYKEGRIRAIG
VSNFNASQMRIAQKRLNKHGLSLASNQVKYNLLDRQIETNGVLETARELGISLIAYSPLAMGVLSGKYQRNPEYLEMVPF
IRRKTIRRALEKSMPVIAKLSEISARYNADIAQVALAWVIYGQGDTVFALAGASTPVQARENLRALDIKLTAAEIAELNS
VSGS

Sequences:

>Translated_324_residues
MDNILDKKWAYRELGQTGIGLSPLGLGSWQFSRGKGAAIGVWGMLNQAKVNEIVLNSLAGGINWFDTAEAYGMGQSEESL
AEALKQAGIRPGECFIATKWQPTMRSASSLKTLLPIREGFLSPYKVDLYQVHFPGLFASIDAQMDNMAALYKEGRIRAIG
VSNFNASQMRIAQKRLNKHGLSLASNQVKYNLLDRQIETNGVLETARELGISLIAYSPLAMGVLSGKYQRNPEYLEMVPF
IRRKTIRRALEKSMPVIAKLSEISARYNADIAQVALAWVIYGQGDTVFALAGASTPVQARENLRALDIKLTAAEIAELNS
VSGS
>Mature_324_residues
MDNILDKKWAYRELGQTGIGLSPLGLGSWQFSRGKGAAIGVWGMLNQAKVNEIVLNSLAGGINWFDTAEAYGMGQSEESL
AEALKQAGIRPGECFIATKWQPTMRSASSLKTLLPIREGFLSPYKVDLYQVHFPGLFASIDAQMDNMAALYKEGRIRAIG
VSNFNASQMRIAQKRLNKHGLSLASNQVKYNLLDRQIETNGVLETARELGISLIAYSPLAMGVLSGKYQRNPEYLEMVPF
IRRKTIRRALEKSMPVIAKLSEISARYNADIAQVALAWVIYGQGDTVFALAGASTPVQARENLRALDIKLTAAEIAELNS
VSGS

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436962, Length=327, Percent_Identity=25.9938837920489, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI27436964, Length=326, Percent_Identity=25.7668711656442, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI27436966, Length=326, Percent_Identity=25.4601226993865, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4504825, Length=329, Percent_Identity=25.2279635258359, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI27436969, Length=329, Percent_Identity=25.531914893617, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI27436971, Length=329, Percent_Identity=23.7082066869301, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI223468663, Length=331, Percent_Identity=25.3776435045317, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788070, Length=327, Percent_Identity=32.7217125382263, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87081735, Length=320, Percent_Identity=30.625, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789375, Length=328, Percent_Identity=27.4390243902439, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789199, Length=350, Percent_Identity=27.7142857142857, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788081, Length=286, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87082198, Length=313, Percent_Identity=26.1980830670927, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI48994888, Length=283, Percent_Identity=25.4416961130742, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6325169, Length=330, Percent_Identity=23.9393939393939, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319958, Length=301, Percent_Identity=24.2524916943522, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325384, Length=188, Percent_Identity=29.2553191489362, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=26.3345195729537, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24644950, Length=331, Percent_Identity=26.2839879154079, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646159, Length=331, Percent_Identity=25.3776435045317, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35489; Mature: 35489

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNILDKKWAYRELGQTGIGLSPLGLGSWQFSRGKGAAIGVWGMLNQAKVNEIVLNSLAG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHC
GINWFDTAEAYGMGQSEESLAEALKQAGIRPGECFIATKWQPTMRSASSLKTLLPIREGF
CCCCHHCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
LSPYKVDLYQVHFPGLFASIDAQMDNMAALYKEGRIRAIGVSNFNASQMRIAQKRLNKHG
CCCEEEEEEEEECCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHC
LSLASNQVKYNLLDRQIETNGVLETARELGISLIAYSPLAMGVLSGKYQRNPEYLEMVPF
CHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHH
IRRKTIRRALEKSMPVIAKLSEISARYNADIAQVALAWVIYGQGDTVFALAGASTPVQAR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHEEHEEECCCCEEEEEECCCCCHHHH
ENLRALDIKLTAAEIAELNSVSGS
CCCEEEEEEEEHHHHHHHHCCCCC
>Mature Secondary Structure
MDNILDKKWAYRELGQTGIGLSPLGLGSWQFSRGKGAAIGVWGMLNQAKVNEIVLNSLAG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHC
GINWFDTAEAYGMGQSEESLAEALKQAGIRPGECFIATKWQPTMRSASSLKTLLPIREGF
CCCCHHCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHC
LSPYKVDLYQVHFPGLFASIDAQMDNMAALYKEGRIRAIGVSNFNASQMRIAQKRLNKHG
CCCEEEEEEEEECCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHC
LSLASNQVKYNLLDRQIETNGVLETARELGISLIAYSPLAMGVLSGKYQRNPEYLEMVPF
CHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHH
IRRKTIRRALEKSMPVIAKLSEISARYNADIAQVALAWVIYGQGDTVFALAGASTPVQAR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHEEHEEECCCCEEEEEECCCCCHHHH
ENLRALDIKLTAAEIAELNSVSGS
CCCEEEEEEEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]