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The map label for this gene is nrd-1 [H]

Identifier: 57234945

GI number: 57234945

Start: 234242

End: 235999

Strand: Direct

Name: nrd-1 [H]

Synonym: DET0244

Alternate gene names: 57234945

Gene position: 234242-235999 (Clockwise)

Preceding gene: 57234946

Following gene: 57234944

Centisome position: 15.94

GC content: 54.1

Gene sequence:

>1758_bases
ATGAAACTAAGCCAAAATGCCAGGATTGTGCTTGAGAAACGTTACCTCAAACGGGACGGGGACGGGAATATTGCCGAATC
CTCGGAGGATATGTTCCGCAGGGTAGCGGACACGGTGGCGGCGGCTGAAAATGCCTATAACCCGCCTGGTAAGGCTGCCT
GTATGGCAGAAGAGTTTTACGGCATGATGACCGGATTTGAGTTCCTGCCCAATTCGCCCACCCTTCTGAATGCCGGGCGG
GAACTGGGGCTTTTATCCTCCTGTTTTGTATTGCCGGTGGCAGATTCGGTTGCGGGGATAGCGAAAGCTGTCGGCGAAGC
CATGGTTATCCACCAGTACGGGGGCGGTACCGGCTTTGCTTTTGATGCCATACGGCCGGAAGATGACCCGGTAAAAAGCG
GCCATAAGGTGGCCGGCGGGCCGGTCAGGCTGGTGGGGGTCTTTTCGGAAGCGGTCAACTACATAAAGCAGGCCGGGGTG
CGCTGCGGCTGCAATTCGGCCAGTCTGCCGGTAAATCACCCGGACATTTTAAAATTTATCCGGGCTAAAGATGAAGGCAG
TCACTCCGCCAACTTCGGCATCAATATTGCCCTGACGGATGATTTTATCCGGAAAGTCCGGCGCGGAGAAGATTATGAGC
TGGTTAACCCGCGCACCGGAAGGGTCAGCGGCAGTTTATCCGCCGCCGAGGTCTTTTACCGCATAGCCCGAAGCTCTTGG
GAAACGGGTGACCCGGGGATAATGTTTATTGACCGCATAAATAAAGATAACCCCACCCCCCGGCTTGGGGAATTTATAAC
TACCGACCCCTGCGGTGGACAGCCTTTGCTACCGTACGAATCAGCCACTTTGGGGACAATAAACCTGTCCGGTATGCTCT
TGAAAGAAGGCAACTGCTGCCGGGTGGATTACCCGCGGCTTGGCGGGCTGATTGCCAAAGCTGTCCGCTTTCTGGATGAC
GTACTGGAGGTAAACCGCTATCCGTCAGCCGAGGTTGAAAAAGCGGCTAGGGCCACCCGCAAAATAGGTCTGGGGTTTAT
GGGCTTTGCCGAGATGCTGATAAAGCTGGGTATCCGCTATGATTCAGCGGAAGCGGTATCCGCAGCAGATGAGCTTATGG
CTTTTGTAAAAGAAGCTGCCTGCCAGGCCACCGAAGAGCTGGCTCTGGAACGGGGGGCTTTTCCGGCTTTTGCAGGCAGT
ATATATGCCCAAAAGGGTGCCAAACCCAGACGGAATGCCACCTGCCTTACCTTTACCAATACCGGCACTACCAGCATTAT
TGCCGATACCTCGGTCGGTATTCACCCCATATATTCGCTGGTTATGGTCCGCAACATACTGGACGGGCAGCGGCTGCTGG
ATATAAACCATGCTTTTGAAGAAACCGCCAGAGAGAGGGGCTTTTTCAGCCCGGCGCTTATAGAAAAACTGCTTACTGGG
GAAAGTCCCTGTAACTGCCCGGAGATACCGGAGGATTACCGCCGGTTGCTGGTTACCGCCCGGGATATTCAGCCGGAATG
GTGTATCAGGGTGCAGGCAGCTTTCCAGAAATATACTGACAATGCTATTTCCCAAACGGTCAATTTCCCTGCCGATGCCT
CGGTTGAGGATATCGCAGATTTATTCCTTAAAGCCCACGAGCTGGGTCTTAAAGGGGTTACGGCTTACCGTGACAGCAGC
CGGGAATTGCAGGTGCTTTGCACCGGTGCGGACTGCCGGGATATAGCCAGAAAGTATTTTGAGGATTGCTGTGTTTAA

Upstream 100 bases:

>100_bases
CCGCTTCAGTTGCCCGCAGATACCTTGATAACGTGGTTACTATGGCCTCTGACAGCCGGGATAACGGCTGGAAGCCGGAA
GTAATTTTTTAGGAATAAAT

Downstream 100 bases:

>100_bases
GGTATCTGGGAAGCCCCAGCCCGGTCTTGTACAGGTCTTTTACGGTGACGGGCGGGGCAAGACCTCGGCCGCTATGGGTG
AGATTGTGCGGGCTGTTTCT

Product: ribonucleotide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MKLSQNARIVLEKRYLKRDGDGNIAESSEDMFRRVADTVAAAENAYNPPGKAACMAEEFYGMMTGFEFLPNSPTLLNAGR
ELGLLSSCFVLPVADSVAGIAKAVGEAMVIHQYGGGTGFAFDAIRPEDDPVKSGHKVAGGPVRLVGVFSEAVNYIKQAGV
RCGCNSASLPVNHPDILKFIRAKDEGSHSANFGINIALTDDFIRKVRRGEDYELVNPRTGRVSGSLSAAEVFYRIARSSW
ETGDPGIMFIDRINKDNPTPRLGEFITTDPCGGQPLLPYESATLGTINLSGMLLKEGNCCRVDYPRLGGLIAKAVRFLDD
VLEVNRYPSAEVEKAARATRKIGLGFMGFAEMLIKLGIRYDSAEAVSAADELMAFVKEAACQATEELALERGAFPAFAGS
IYAQKGAKPRRNATCLTFTNTGTTSIIADTSVGIHPIYSLVMVRNILDGQRLLDINHAFEETARERGFFSPALIEKLLTG
ESPCNCPEIPEDYRRLLVTARDIQPEWCIRVQAAFQKYTDNAISQTVNFPADASVEDIADLFLKAHELGLKGVTAYRDSS
RELQVLCTGADCRDIARKYFEDCCV

Sequences:

>Translated_585_residues
MKLSQNARIVLEKRYLKRDGDGNIAESSEDMFRRVADTVAAAENAYNPPGKAACMAEEFYGMMTGFEFLPNSPTLLNAGR
ELGLLSSCFVLPVADSVAGIAKAVGEAMVIHQYGGGTGFAFDAIRPEDDPVKSGHKVAGGPVRLVGVFSEAVNYIKQAGV
RCGCNSASLPVNHPDILKFIRAKDEGSHSANFGINIALTDDFIRKVRRGEDYELVNPRTGRVSGSLSAAEVFYRIARSSW
ETGDPGIMFIDRINKDNPTPRLGEFITTDPCGGQPLLPYESATLGTINLSGMLLKEGNCCRVDYPRLGGLIAKAVRFLDD
VLEVNRYPSAEVEKAARATRKIGLGFMGFAEMLIKLGIRYDSAEAVSAADELMAFVKEAACQATEELALERGAFPAFAGS
IYAQKGAKPRRNATCLTFTNTGTTSIIADTSVGIHPIYSLVMVRNILDGQRLLDINHAFEETARERGFFSPALIEKLLTG
ESPCNCPEIPEDYRRLLVTARDIQPEWCIRVQAAFQKYTDNAISQTVNFPADASVEDIADLFLKAHELGLKGVTAYRDSS
RELQVLCTGADCRDIARKYFEDCCV
>Mature_585_residues
MKLSQNARIVLEKRYLKRDGDGNIAESSEDMFRRVADTVAAAENAYNPPGKAACMAEEFYGMMTGFEFLPNSPTLLNAGR
ELGLLSSCFVLPVADSVAGIAKAVGEAMVIHQYGGGTGFAFDAIRPEDDPVKSGHKVAGGPVRLVGVFSEAVNYIKQAGV
RCGCNSASLPVNHPDILKFIRAKDEGSHSANFGINIALTDDFIRKVRRGEDYELVNPRTGRVSGSLSAAEVFYRIARSSW
ETGDPGIMFIDRINKDNPTPRLGEFITTDPCGGQPLLPYESATLGTINLSGMLLKEGNCCRVDYPRLGGLIAKAVRFLDD
VLEVNRYPSAEVEKAARATRKIGLGFMGFAEMLIKLGIRYDSAEAVSAADELMAFVKEAACQATEELALERGAFPAFAGS
IYAQKGAKPRRNATCLTFTNTGTTSIIADTSVGIHPIYSLVMVRNILDGQRLLDINHAFEETARERGFFSPALIEKLLTG
ESPCNCPEIPEDYRRLLVTARDIQPEWCIRVQAAFQKYTDNAISQTVNFPADASVEDIADLFLKAHELGLKGVTAYRDSS
RELQVLCTGADCRDIARKYFEDCCV

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=603, Percent_Identity=23.5489220563847, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1789030, Length=555, Percent_Identity=25.7657657657658, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17555242, Length=601, Percent_Identity=23.1281198003328, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320914, Length=599, Percent_Identity=23.7061769616027, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6322123, Length=604, Percent_Identity=23.5099337748344, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17352481, Length=606, Percent_Identity=22.7722772277228, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 63760; Mature: 63760

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSQNARIVLEKRYLKRDGDGNIAESSEDMFRRVADTVAAAENAYNPPGKAACMAEEFY
CCCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GMMTGFEFLPNSPTLLNAGRELGLLSSCFVLPVADSVAGIAKAVGEAMVIHQYGGGTGFA
HHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
FDAIRPEDDPVKSGHKVAGGPVRLVGVFSEAVNYIKQAGVRCGCNSASLPVNHPDILKFI
ECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHH
RAKDEGSHSANFGINIALTDDFIRKVRRGEDYELVNPRTGRVSGSLSAAEVFYRIARSSW
HHCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC
ETGDPGIMFIDRINKDNPTPRLGEFITTDPCGGQPLLPYESATLGTINLSGMLLKEGNCC
CCCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEECEEEEECCCEE
RVDYPRLGGLIAKAVRFLDDVLEVNRYPSAEVEKAARATRKIGLGFMGFAEMLIKLGIRY
EECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
DSAEAVSAADELMAFVKEAACQATEELALERGAFPAFAGSIYAQKGAKPRRNATCLTFTN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEC
TGTTSIIADTSVGIHPIYSLVMVRNILDGQRLLDINHAFEETARERGFFSPALIEKLLTG
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHCC
ESPCNCPEIPEDYRRLLVTARDIQPEWCIRVQAAFQKYTDNAISQTVNFPADASVEDIAD
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LFLKAHELGLKGVTAYRDSSRELQVLCTGADCRDIARKYFEDCCV
HHHHHHHHCCCCEEHHCCCCCCEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLSQNARIVLEKRYLKRDGDGNIAESSEDMFRRVADTVAAAENAYNPPGKAACMAEEFY
CCCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GMMTGFEFLPNSPTLLNAGRELGLLSSCFVLPVADSVAGIAKAVGEAMVIHQYGGGTGFA
HHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEE
FDAIRPEDDPVKSGHKVAGGPVRLVGVFSEAVNYIKQAGVRCGCNSASLPVNHPDILKFI
ECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHH
RAKDEGSHSANFGINIALTDDFIRKVRRGEDYELVNPRTGRVSGSLSAAEVFYRIARSSW
HHCCCCCCCCCCCEEEEECHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC
ETGDPGIMFIDRINKDNPTPRLGEFITTDPCGGQPLLPYESATLGTINLSGMLLKEGNCC
CCCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEECEEEEECCCEE
RVDYPRLGGLIAKAVRFLDDVLEVNRYPSAEVEKAARATRKIGLGFMGFAEMLIKLGIRY
EECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
DSAEAVSAADELMAFVKEAACQATEELALERGAFPAFAGSIYAQKGAKPRRNATCLTFTN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEEC
TGTTSIIADTSVGIHPIYSLVMVRNILDGQRLLDINHAFEETARERGFFSPALIEKLLTG
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHCC
ESPCNCPEIPEDYRRLLVTARDIQPEWCIRVQAAFQKYTDNAISQTVNFPADASVEDIAD
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LFLKAHELGLKGVTAYRDSSRELQVLCTGADCRDIARKYFEDCCV
HHHHHHHHCCCCEEHHCCCCCCEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]