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The map label for this gene is atpA

Identifier: 57234628

GI number: 57234628

Start: 516254

End: 517765

Strand: Direct

Name: atpA

Synonym: DET0562

Alternate gene names: 57234628

Gene position: 516254-517765 (Clockwise)

Preceding gene: 57234629

Following gene: 57234627

Centisome position: 35.13

GC content: 50.73

Gene sequence:

>1512_bases
TTGAGCGCACGTGGTCAAGATATAGTATCTATTATTAAAGAGCAGATAAAAGAATTCGGGGCTCCGGTCAGTATGACCAG
CGTCGGTTCGGTTATCGAAGTAGGCGATGGTATCGCCCGTATTCATGGTCTTTCCAACGCCAAGTACAACGAACTTCTGG
AATTTCCCGGCGGTGTTATGGGCATTGCCCTTAACCTTGAAGAAGACAGCGTAGCCGCTGTTATCCTGGGTGATGATGCC
AATATTAAAGAAGGCGATGAAGTAAAGGCTACCGGCCGTATATCTGAAATTACGGTTGGTAAAGGTATGATAGGCCGCGT
GGTAGACCCCTTGGGCCGCCCTCTGGACGGCAAAGGTCCTATCAAGGCTGAAACAGTCCGTCCTCTTGAACGCATCGCCC
CCAACGTAGTTGACCGTAAATCGGTAAATACCCCGGTTCAGACCGGTATTAAGGCTATTGATGCCATGATACCCATCGGC
CGCGGTCAGCGTGAGCTGATTATTGGTGACCGTTCAACCGGTAAAACCGCCATTGCCCTGGATACCATTATTAACCAGAA
GGGCGGAGACCTGGTTTGTATTTATGTGGCTATCGGCCAGAAAGCTTCTAAAGTAGCCCGGACAGTAGCTTTGCTTGAGC
AGTACGGCGCTATGGAGCACACTATTGTGGTTGCGGCCAACTCTTCTGATGCGGTTGCTTTGCAGTATCTGGCACCTTAT
GCCGGCTGCGCTATCGGCGAAGAGTTTATGGAACAGGGTCAGGATGCTCTGGTAGTCTATGATGACCTTACCAAGCACGC
TTGGGCTTACCGCCAGCTTTCCCTCCTTCTGCGCCGCCCGCCCGGCCGTGAGGCTTATCCGGGTGACGTGTTTTACCTGC
ACAGCCGGTTGCTGGAACGGGCTGCCCGCCTTAACGACAAGCTCGGCGGCGGTTCGCTGACTGCTTTGCCTATTATTGAA
ACTCAGGCCGGAGACGTTTCGGCTTATGTACCTACCAACGTTATCTCCATTACTGATGGTCAGATTTACCTTGAACCTGA
TATGTTTAACTCCGGTATCCGCCCTGCGGTCAACGTAGGTATATCGGTATCCCGAGTAGGTTCAAGCGCCCAGACTAAGG
CCATGAAAAAGGTTGCCAGCAAGCTGAAGATGGATATGGGTCAGTATCGTGAACTGGCCGCTTTTGCCCAGTTTGGTACT
TCCGAACTGGATAAAGCTACCCGTATGCAGCTTGAACGCGGTCAAAGAATCACCGAGGTACTTAAACAGGGACAGTACCA
GCCGGTACCTATGGCTAATCAGGTTGCTATCCTGTATGCCGCACTCAACGGGTACCTTGACAGTGTAGAAGTGGCTAAAG
TACGTGATTTTGAAAGCGGGCTTTATCGCTTCCTTGAAGCGAACTTTGCTTCAGTGCTGAACAATATCACCAAGGAAAAT
GCCATCTCTGCTGAAACCGAGACAGCCCTTAAGACCGCTTTGGATGATTACAAGAAGGGTTTAGTAGTATAA

Upstream 100 bases:

>100_bases
GGGGATAAACTGATAGATGGTTCTGTCAGCCGGAGGCTGGTCTTACTGCAAAACGAAATCAGTCAGGGACGTATTTGATA
ACCCTCAGGAGGTGGCGTAA

Downstream 100 bases:

>100_bases
ATTTCGAACCTGGCGGGAAGTTAAATGGCTAATATAAGAATAATAAAAAGGCGTATCCGCAGTGTCCGTAACATAGCCAA
GATTACCAGGGCTATGGAAA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MSARGQDIVSIIKEQIKEFGAPVSMTSVGSVIEVGDGIARIHGLSNAKYNELLEFPGGVMGIALNLEEDSVAAVILGDDA
NIKEGDEVKATGRISEITVGKGMIGRVVDPLGRPLDGKGPIKAETVRPLERIAPNVVDRKSVNTPVQTGIKAIDAMIPIG
RGQRELIIGDRSTGKTAIALDTIINQKGGDLVCIYVAIGQKASKVARTVALLEQYGAMEHTIVVAANSSDAVALQYLAPY
AGCAIGEEFMEQGQDALVVYDDLTKHAWAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDKLGGGSLTALPIIE
TQAGDVSAYVPTNVISITDGQIYLEPDMFNSGIRPAVNVGISVSRVGSSAQTKAMKKVASKLKMDMGQYRELAAFAQFGT
SELDKATRMQLERGQRITEVLKQGQYQPVPMANQVAILYAALNGYLDSVEVAKVRDFESGLYRFLEANFASVLNNITKEN
AISAETETALKTALDDYKKGLVV

Sequences:

>Translated_503_residues
MSARGQDIVSIIKEQIKEFGAPVSMTSVGSVIEVGDGIARIHGLSNAKYNELLEFPGGVMGIALNLEEDSVAAVILGDDA
NIKEGDEVKATGRISEITVGKGMIGRVVDPLGRPLDGKGPIKAETVRPLERIAPNVVDRKSVNTPVQTGIKAIDAMIPIG
RGQRELIIGDRSTGKTAIALDTIINQKGGDLVCIYVAIGQKASKVARTVALLEQYGAMEHTIVVAANSSDAVALQYLAPY
AGCAIGEEFMEQGQDALVVYDDLTKHAWAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDKLGGGSLTALPIIE
TQAGDVSAYVPTNVISITDGQIYLEPDMFNSGIRPAVNVGISVSRVGSSAQTKAMKKVASKLKMDMGQYRELAAFAQFGT
SELDKATRMQLERGQRITEVLKQGQYQPVPMANQVAILYAALNGYLDSVEVAKVRDFESGLYRFLEANFASVLNNITKEN
AISAETETALKTALDDYKKGLVV
>Mature_502_residues
SARGQDIVSIIKEQIKEFGAPVSMTSVGSVIEVGDGIARIHGLSNAKYNELLEFPGGVMGIALNLEEDSVAAVILGDDAN
IKEGDEVKATGRISEITVGKGMIGRVVDPLGRPLDGKGPIKAETVRPLERIAPNVVDRKSVNTPVQTGIKAIDAMIPIGR
GQRELIIGDRSTGKTAIALDTIINQKGGDLVCIYVAIGQKASKVARTVALLEQYGAMEHTIVVAANSSDAVALQYLAPYA
GCAIGEEFMEQGQDALVVYDDLTKHAWAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDKLGGGSLTALPIIET
QAGDVSAYVPTNVISITDGQIYLEPDMFNSGIRPAVNVGISVSRVGSSAQTKAMKKVASKLKMDMGQYRELAAFAQFGTS
ELDKATRMQLERGQRITEVLKQGQYQPVPMANQVAILYAALNGYLDSVEVAKVRDFESGLYRFLEANFASVLNNITKENA
ISAETETALKTALDDYKKGLVV

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=57.455268389662, Blast_Score=587, Evalue=1e-168,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=57.455268389662, Blast_Score=587, Evalue=1e-168,
Organism=Homo sapiens, GI19913426, Length=358, Percent_Identity=26.2569832402235, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19913428, Length=309, Percent_Identity=27.5080906148867, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI32189394, Length=381, Percent_Identity=24.6719160104987, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI19913424, Length=340, Percent_Identity=25, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1790172, Length=509, Percent_Identity=56.5815324165029, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1788251, Length=328, Percent_Identity=28.0487804878049, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790170, Length=412, Percent_Identity=24.0291262135922, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=56.4612326043738, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=56.4612326043738, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=52.6838966202783, Blast_Score=529, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17510931, Length=378, Percent_Identity=25.9259259259259, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=307, Percent_Identity=28.0130293159609, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=418, Percent_Identity=23.444976076555, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=58, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=77, Percent_Identity=37.6623376623377, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=503, Percent_Identity=56.6600397614314, Blast_Score=579, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319603, Length=415, Percent_Identity=26.5060240963855, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322581, Length=416, Percent_Identity=25.4807692307692, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24658560, Length=498, Percent_Identity=56.2248995983936, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=309, Percent_Identity=27.5080906148867, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646341, Length=309, Percent_Identity=27.5080906148867, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136796, Length=309, Percent_Identity=27.5080906148867, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24638766, Length=384, Percent_Identity=24.7395833333333, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574560, Length=410, Percent_Identity=25.3658536585366, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI20129479, Length=325, Percent_Identity=27.3846153846154, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583992, Length=340, Percent_Identity=23.8235294117647, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583988, Length=347, Percent_Identity=23.342939481268, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583986, Length=347, Percent_Identity=23.342939481268, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583984, Length=347, Percent_Identity=23.342939481268, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_DEHE1 (Q3Z8Z4)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181305.1
- ProteinModelPortal:   Q3Z8Z4
- SMR:   Q3Z8Z4
- STRING:   Q3Z8Z4
- GeneID:   3230096
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0562
- NMPDR:   fig|243164.3.peg.420
- TIGR:   DET0562
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q3Z8Z4
- ProtClustDB:   PRK09281
- BioCyc:   DETH243164:DET_0562-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54086; Mature: 53955

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARGQDIVSIIKEQIKEFGAPVSMTSVGSVIEVGDGIARIHGLSNAKYNELLEFPGGVM
CCCCHHHHHHHHHHHHHHHCCCEEHHHCCCHHHHCCCHHHHHCCCCCCHHHHHHCCCCEE
GIALNLEEDSVAAVILGDDANIKEGDEVKATGRISEITVGKGMIGRVVDPLGRPLDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCC
IKAETVRPLERIAPNVVDRKSVNTPVQTGIKAIDAMIPIGRGQRELIIGDRSTGKTAIAL
CCHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKGGDLVCIYVAIGQKASKVARTVALLEQYGAMEHTIVVAANSSDAVALQYLAPY
HHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHH
AGCAIGEEFMEQGQDALVVYDDLTKHAWAYRQLSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARLNDKLGGGSLTALPIIETQAGDVSAYVPTNVISITDGQIYLEPDMFNSGIRPAVNVG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHCC
ISVSRVGSSAQTKAMKKVASKLKMDMGQYRELAAFAQFGTSELDKATRMQLERGQRITEV
EEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
LKQGQYQPVPMANQVAILYAALNGYLDSVEVAKVRDFESGLYRFLEANFASVLNNITKEN
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISAETETALKTALDDYKKGLVV
CCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SARGQDIVSIIKEQIKEFGAPVSMTSVGSVIEVGDGIARIHGLSNAKYNELLEFPGGVM
CCCHHHHHHHHHHHHHHHCCCEEHHHCCCHHHHCCCHHHHHCCCCCCHHHHHHCCCCEE
GIALNLEEDSVAAVILGDDANIKEGDEVKATGRISEITVGKGMIGRVVDPLGRPLDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCC
IKAETVRPLERIAPNVVDRKSVNTPVQTGIKAIDAMIPIGRGQRELIIGDRSTGKTAIAL
CCHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKGGDLVCIYVAIGQKASKVARTVALLEQYGAMEHTIVVAANSSDAVALQYLAPY
HHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEHHHHHHH
AGCAIGEEFMEQGQDALVVYDDLTKHAWAYRQLSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARLNDKLGGGSLTALPIIETQAGDVSAYVPTNVISITDGQIYLEPDMFNSGIRPAVNVG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHCC
ISVSRVGSSAQTKAMKKVASKLKMDMGQYRELAAFAQFGTSELDKATRMQLERGQRITEV
EEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
LKQGQYQPVPMANQVAILYAALNGYLDSVEVAKVRDFESGLYRFLEANFASVLNNITKEN
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISAETETALKTALDDYKKGLVV
CCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA