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The map label for this gene is ddl [H]

Identifier: 57234544

GI number: 57234544

Start: 583767

End: 584783

Strand: Direct

Name: ddl [H]

Synonym: DET0629

Alternate gene names: 57234544

Gene position: 583767-584783 (Clockwise)

Preceding gene: 57234545

Following gene: 57234543

Centisome position: 39.72

GC content: 50.54

Gene sequence:

>1017_bases
ATGCAGATAGGGCTGTCATACGATCTTAAACAGGCGTTAAATCCGGTTAGCGGCGGCCCTGATGATGCGCTGGAAGAATA
TGACTCACCGGAGACGGTTGAAGCTATCACTAATGCTTTAACCCAGGCCGGGCATACGGTTTACCGCTTGGGTGGGGGAA
AAGAGTTTTTACGCAGGGTACAGGAACAAAAACTTGACCTGGTTTTCAATATTGCGGAGGGTTTGGGCAATTACCGCAGC
CGTGAGGCTCAAATTCCCGGTATTTTAGAGATGTTAGATATACCGTACACCGGCTCAGATCCGCAGACACTGGCGGTCTG
TCTGGATAAACCCCTGACTAAGAAACTGGTAGCTGATGCCGGTATAAAAACTGCCCGGTGGCAGTTAGTCACCAGCTGCG
AAGAGCTTTCGGCTATAGACTGGTCAGGGTTCCCCTTGCCGGCTTTTCTTAAGCCTGCCTGTGAGGGTTCTAGCAAGGGT
GTCAGGTTTGCTTCACGCGCCGGAAGTGCCAAAGAAATAGTAAGCATGGCGGCAGAGCTGCTTACTGCCTATGAGCAGCC
TGTTTTGATAGAAGAATTTATAAGCGGCGAAGAGATTACGGTAGGGGTTATCGGTAATATACAGCCCAAAGTTTTGGGTA
TCATGCGGGTTGTCCCCAAAACCAAAACTGATTATTTTGTCTACTCTGTAGAGGTGAAACGCAACTGGCGGCAGATGGTG
GAGTATGAGGTACCGGCGGCTTTGCCTGCTGAGACTTTATCCCGCATTGAAAAGGCTACGCTGGATGCGTATAAGGTGCT
GGGCTGCCGTGACCTGTGCCGTATGGATTTCAGGGTCAGCCCTGACGGCATACCTTATTTTCTGGAAGTAAACCCTTTGC
CCGGTCTGAACCCTGTCAGCGGAGATTTGCCGATTATGGCATCTAAACTGGGTATCAGTCATGCTGAGTTGGTGTTAAAA
ATACTTGACACTGCTCTGGCCCGCCACAGTCTGACTGCGGCAAACTGCCTGCCTTAG

Upstream 100 bases:

>100_bases
GATATAATCCGTTTTAAAAATCCGGGTGACCCCAAAGTTTACAGCAATACCGGCCGGACAGATTTACTTAATAATGCCGC
TAAAATAAAGAGAGAAACAG

Downstream 100 bases:

>100_bases
GTTAAATAAAATGTTATATAAAGGCCTCCTCCGGGAGGCTTTTTATTTTAAGGGATAATTAACCCCCGTGATTCTTGCTA
TTTGAAAAAGCCGAAGCTAT

Product: D-ala D-ala ligase

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MQIGLSYDLKQALNPVSGGPDDALEEYDSPETVEAITNALTQAGHTVYRLGGGKEFLRRVQEQKLDLVFNIAEGLGNYRS
REAQIPGILEMLDIPYTGSDPQTLAVCLDKPLTKKLVADAGIKTARWQLVTSCEELSAIDWSGFPLPAFLKPACEGSSKG
VRFASRAGSAKEIVSMAAELLTAYEQPVLIEEFISGEEITVGVIGNIQPKVLGIMRVVPKTKTDYFVYSVEVKRNWRQMV
EYEVPAALPAETLSRIEKATLDAYKVLGCRDLCRMDFRVSPDGIPYFLEVNPLPGLNPVSGDLPIMASKLGISHAELVLK
ILDTALARHSLTAANCLP

Sequences:

>Translated_338_residues
MQIGLSYDLKQALNPVSGGPDDALEEYDSPETVEAITNALTQAGHTVYRLGGGKEFLRRVQEQKLDLVFNIAEGLGNYRS
REAQIPGILEMLDIPYTGSDPQTLAVCLDKPLTKKLVADAGIKTARWQLVTSCEELSAIDWSGFPLPAFLKPACEGSSKG
VRFASRAGSAKEIVSMAAELLTAYEQPVLIEEFISGEEITVGVIGNIQPKVLGIMRVVPKTKTDYFVYSVEVKRNWRQMV
EYEVPAALPAETLSRIEKATLDAYKVLGCRDLCRMDFRVSPDGIPYFLEVNPLPGLNPVSGDLPIMASKLGISHAELVLK
ILDTALARHSLTAANCLP
>Mature_338_residues
MQIGLSYDLKQALNPVSGGPDDALEEYDSPETVEAITNALTQAGHTVYRLGGGKEFLRRVQEQKLDLVFNIAEGLGNYRS
REAQIPGILEMLDIPYTGSDPQTLAVCLDKPLTKKLVADAGIKTARWQLVTSCEELSAIDWSGFPLPAFLKPACEGSSKG
VRFASRAGSAKEIVSMAAELLTAYEQPVLIEEFISGEEITVGVIGNIQPKVLGIMRVVPKTKTDYFVYSVEVKRNWRQMV
EYEVPAALPAETLSRIEKATLDAYKVLGCRDLCRMDFRVSPDGIPYFLEVNPLPGLNPVSGDLPIMASKLGISHAELVLK
ILDTALARHSLTAANCLP

Specific function: Cell wall formation [H]

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786579, Length=271, Percent_Identity=29.8892988929889, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786280, Length=299, Percent_Identity=28.4280936454849, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185 [H]

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N [H]

EC number: =6.3.2.4 [H]

Molecular weight: Translated: 36882; Mature: 36882

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50975 ATP_GRASP ; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGLSYDLKQALNPVSGGPDDALEEYDSPETVEAITNALTQAGHTVYRLGGGKEFLRRV
CCCCCCCCHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
QEQKLDLVFNIAEGLGNYRSREAQIPGILEMLDIPYTGSDPQTLAVCLDKPLTKKLVADA
HHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHCCCCCCCCCCEEHEECCCHHHHHHHHHC
GIKTARWQLVTSCEELSAIDWSGFPLPAFLKPACEGSSKGVRFASRAGSAKEIVSMAAEL
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHH
LTAYEQPVLIEEFISGEEITVGVIGNIQPKVLGIMRVVPKTKTDYFVYSVEVKRNWRQMV
HHHHCCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHH
EYEVPAALPAETLSRIEKATLDAYKVLGCRDLCRMDFRVSPDGIPYFLEVNPLPGLNPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCCCCC
GDLPIMASKLGISHAELVLKILDTALARHSLTAANCLP
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MQIGLSYDLKQALNPVSGGPDDALEEYDSPETVEAITNALTQAGHTVYRLGGGKEFLRRV
CCCCCCCCHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
QEQKLDLVFNIAEGLGNYRSREAQIPGILEMLDIPYTGSDPQTLAVCLDKPLTKKLVADA
HHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHCCCCCCCCCCEEHEECCCHHHHHHHHHC
GIKTARWQLVTSCEELSAIDWSGFPLPAFLKPACEGSSKGVRFASRAGSAKEIVSMAAEL
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHH
LTAYEQPVLIEEFISGEEITVGVIGNIQPKVLGIMRVVPKTKTDYFVYSVEVKRNWRQMV
HHHHCCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHH
EYEVPAALPAETLSRIEKATLDAYKVLGCRDLCRMDFRVSPDGIPYFLEVNPLPGLNPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCCCCCC
GDLPIMASKLGISHAELVLKILDTALARHSLTAANCLP
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]