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The map label for this gene is cobC [H]

Identifier: 57234513

GI number: 57234513

Start: 638642

End: 639244

Strand: Direct

Name: cobC [H]

Synonym: DET0693

Alternate gene names: 57234513

Gene position: 638642-639244 (Clockwise)

Preceding gene: 57234514

Following gene: 57234512

Centisome position: 43.45

GC content: 49.25

Gene sequence:

>603_bases
ATGAAACTGATACTGGTGCGTCACGGGGAGACCGAAACAGATAACTGCCGCTGTTACTGGGGGCATAGTGATATCGGCCT
TTCAGACTCCGGCCATGCTCAGGCTAACTCCCTGCGGGAATATTTGTCTGCGGTCAGGATAGATGCCATTTATTCCAGCC
CTCTTAAACGCTGCATGGAAACTGCTGAAACCATTGCCTACGGGCGGCCTCTTTCAGTCAATAAAAATAATGACCTGAAG
GAAATAGATTTCGGGCGGGTAGAGGGCCTTACCTACGATGATGTTTTAGAACGCTACCCGGATATTGCCCAGAAATGGGC
TGAGGGCAGTTTTGACGTGCATTTCCCGGACGGGGAAGGCATGGAACATTTTGCCCAGCGGGTTGTTAAATTTGTAAAAA
TGCTCTCCAAGCACCGGGAGGATGAGACTTTATTACTGGTGGGGCACGGGGGTGTTTTCCGTATCCTTATCTGCCATTTT
CTGGGCATTGATTACAAACACTGGTGGCAGTTTACGCTGGGTGTTGGCTCGGTAACTGTTCTGGATATTTATCCCGAGGG
GTCTATACTGGAAAAACTGAACGATAAATCCCATCTGGGCTGA

Upstream 100 bases:

>100_bases
GATACTTACGGCTCAATTAACGAGTTTACCGAGGTAGCGGCGCTGATATTTATAGTGGCCTTGTCCGGGTATTTCAGCTG
AAATAGAGGGAGTTTATAGC

Downstream 100 bases:

>100_bases
TTTTTAACTTTTGTTCAGGCAGGGCGTTTTTATAATACCGGAGGGTCATTAAAATGAATTATTTACTTATCGGCGGTGCC
CGCAGCGGCAAAAGCAGTTA

Product: alpha-ribazole-5-phosphate phosphatase, putative

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKLILVRHGETETDNCRCYWGHSDIGLSDSGHAQANSLREYLSAVRIDAIYSSPLKRCMETAETIAYGRPLSVNKNNDLK
EIDFGRVEGLTYDDVLERYPDIAQKWAEGSFDVHFPDGEGMEHFAQRVVKFVKMLSKHREDETLLLVGHGGVFRILICHF
LGIDYKHWWQFTLGVGSVTVLDIYPEGSILEKLNDKSHLG

Sequences:

>Translated_200_residues
MKLILVRHGETETDNCRCYWGHSDIGLSDSGHAQANSLREYLSAVRIDAIYSSPLKRCMETAETIAYGRPLSVNKNNDLK
EIDFGRVEGLTYDDVLERYPDIAQKWAEGSFDVHFPDGEGMEHFAQRVVKFVKMLSKHREDETLLLVGHGGVFRILICHF
LGIDYKHWWQFTLGVGSVTVLDIYPEGSILEKLNDKSHLG
>Mature_200_residues
MKLILVRHGETETDNCRCYWGHSDIGLSDSGHAQANSLREYLSAVRIDAIYSSPLKRCMETAETIAYGRPLSVNKNNDLK
EIDFGRVEGLTYDDVLERYPDIAQKWAEGSFDVHFPDGEGMEHFAQRVVKFVKMLSKHREDETLLLVGHGGVFRILICHF
LGIDYKHWWQFTLGVGSVTVLDIYPEGSILEKLNDKSHLG

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI118582286, Length=161, Percent_Identity=32.9192546583851, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4758902, Length=161, Percent_Identity=32.9192546583851, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI64762406, Length=161, Percent_Identity=31.6770186335404, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI64762445, Length=161, Percent_Identity=31.6770186335404, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4758900, Length=161, Percent_Identity=29.1925465838509, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI224282149, Length=161, Percent_Identity=29.1925465838509, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1786857, Length=197, Percent_Identity=30.4568527918782, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1790856, Length=205, Percent_Identity=28.780487804878, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324857, Length=210, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24643264, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643254, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643260, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643258, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643256, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643262, Length=161, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643252, Length=161, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137706, Length=161, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 22758; Mature: 22758

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLILVRHGETETDNCRCYWGHSDIGLSDSGHAQANSLREYLSAVRIDAIYSSPLKRCME
CEEEEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAETIAYGRPLSVNKNNDLKEIDFGRVEGLTYDDVLERYPDIAQKWAEGSFDVHFPDGEG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHCCCCCEEECCCCCC
MEHFAQRVVKFVKMLSKHREDETLLLVGHGGVFRILICHFLGIDYKHWWQFTLGVGSVTV
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHEEEEECCCCEEE
LDIYPEGSILEKLNDKSHLG
EEECCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MKLILVRHGETETDNCRCYWGHSDIGLSDSGHAQANSLREYLSAVRIDAIYSSPLKRCME
CEEEEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAETIAYGRPLSVNKNNDLKEIDFGRVEGLTYDDVLERYPDIAQKWAEGSFDVHFPDGEG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHCCCCCEEECCCCCC
MEHFAQRVVKFVKMLSKHREDETLLLVGHGGVFRILICHFLGIDYKHWWQFTLGVGSVTV
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHEEEEECCCCEEE
LDIYPEGSILEKLNDKSHLG
EEECCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]