Click here to switch to the map view.

The map label for this gene is panC

Identifier: 57234370

GI number: 57234370

Start: 738293

End: 739099

Strand: Direct

Name: panC

Synonym: DET0804

Alternate gene names: 57234370

Gene position: 738293-739099 (Clockwise)

Preceding gene: 57234371

Following gene: 57234464

Centisome position: 50.23

GC content: 48.45

Gene sequence:

>807_bases
ATGCAAAAACTGCACCGTGAAATCTGCGGACCGGTTGGCCTGGTGCCGACTATGGGCTATCTGCACGAAGGGCATTTGTC
ACTGATTAGGGCTTCTAAAAAACAGGATCTAAATACGGTCGCCAGTATCTTTGTTAATCCCACCCAGTTCGGGCCGCATG
AGGATTTTAAAAAGTACCCCCGTGACGAAAAACGGGATATGGCCATGCTGGAAAATGCCGGTGTGGATTATGTCTTTGCC
CCGTCCGTTGAGGAAATGTATCCACCCGGCTTTGATTCATGGGTAGAGCCTGGTGTTTTGCAGGAACGTCTGGAAGGGGC
TGTCCGTCCGGGGCATTTCCGCGGGGTATGTACTGTTGTGGCGAAACTTTTTACAATAATCTGCCCTGCCAAAGCCTATT
TCGGGCAGAAAGATTACCAGCAGTACCTCATAATAAAAAAAATGGCCTCAGACCTTAATCTGGACGTATCAGTGGAAATG
CTGCCCATAGTGCGTGAGAGTGACGGTCTGGCACTAAGCAGCCGTAATACCTATCTTTCTGCTTCAGAGCGTAAGGCGGC
TTTGGTGCTTTACCGCTCCCTGCTCACAGCCAAAAGCTTGTTTGCTGCAAAAGAGTACAACCCGGAGATTATTCGCAGAA
AAATGACTGAGGAAATACAGCGCGAATCCCTGGCGGAAATAGATTATGTCAGCTTGTCAGACCAGGATACCCTGGGTGAG
GCGGATAAAGTATCTATAAAAACTATTGCCCTGGTAGCTGCCAGATTCGGCAAAACCCGTCTGATAGACAATATGTTTTT
AGCCTAA

Upstream 100 bases:

>100_bases
TTGCAAAAGGTGAATTTCCCACTTTGAAAGAAAGCTTCACCCTTGATAAAAAGGTATTGGAGGAACTGAAAAAGTGCGTA
TCATCAGAACAGTAGCCGAG

Downstream 100 bases:

>100_bases
GCTGCCCCCGCAGGTTTTTTCTTTGGCGGTTCTTTGATAAATACCAGCAAACCGATAACGGCAAGCAAGGCCAGTGCCGC
CCCGAAGTAAAATGGTGCTG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MQKLHREICGPVGLVPTMGYLHEGHLSLIRASKKQDLNTVASIFVNPTQFGPHEDFKKYPRDEKRDMAMLENAGVDYVFA
PSVEEMYPPGFDSWVEPGVLQERLEGAVRPGHFRGVCTVVAKLFTIICPAKAYFGQKDYQQYLIIKKMASDLNLDVSVEM
LPIVRESDGLALSSRNTYLSASERKAALVLYRSLLTAKSLFAAKEYNPEIIRRKMTEEIQRESLAEIDYVSLSDQDTLGE
ADKVSIKTIALVAARFGKTRLIDNMFLA

Sequences:

>Translated_268_residues
MQKLHREICGPVGLVPTMGYLHEGHLSLIRASKKQDLNTVASIFVNPTQFGPHEDFKKYPRDEKRDMAMLENAGVDYVFA
PSVEEMYPPGFDSWVEPGVLQERLEGAVRPGHFRGVCTVVAKLFTIICPAKAYFGQKDYQQYLIIKKMASDLNLDVSVEM
LPIVRESDGLALSSRNTYLSASERKAALVLYRSLLTAKSLFAAKEYNPEIIRRKMTEEIQRESLAEIDYVSLSDQDTLGE
ADKVSIKTIALVAARFGKTRLIDNMFLA
>Mature_268_residues
MQKLHREICGPVGLVPTMGYLHEGHLSLIRASKKQDLNTVASIFVNPTQFGPHEDFKKYPRDEKRDMAMLENAGVDYVFA
PSVEEMYPPGFDSWVEPGVLQERLEGAVRPGHFRGVCTVVAKLFTIICPAKAYFGQKDYQQYLIIKKMASDLNLDVSVEM
LPIVRESDGLALSSRNTYLSASERKAALVLYRSLLTAKSLFAAKEYNPEIIRRKMTEEIQRESLAEIDYVSLSDQDTLGE
ADKVSIKTIALVAARFGKTRLIDNMFLA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=255, Percent_Identity=45.0980392156863, Blast_Score=212, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322046, Length=248, Percent_Identity=43.5483870967742, Blast_Score=191, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_DEHE1 (Q3Z8B3)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181536.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q3Z8B3
- SMR:   Q3Z8B3
- STRING:   Q3Z8B3
- GeneID:   3229837
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0804
- NMPDR:   fig|243164.3.peg.996
- TIGR:   DET0804
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q3Z8B3
- ProtClustDB:   PRK00380
- BioCyc:   DETH243164:DET_0804-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30142; Mature: 30142

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: ACT_SITE 25-25 BINDING 49-49 BINDING 49-49 BINDING 141-141 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLHREICGPVGLVPTMGYLHEGHLSLIRASKKQDLNTVASIFVNPTQFGPHEDFKKYP
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCC
RDEKRDMAMLENAGVDYVFAPSVEEMYPPGFDSWVEPGVLQERLEGAVRPGHFRGVCTVV
CCHHHHHHHHHHCCCCEEECCCHHHHCCCCCCHHCCCHHHHHHHHCCCCCCCHHHHHHHH
AKLFTIICPAKAYFGQKDYQQYLIIKKMASDLNLDVSVEMLPIVRESDGLALSSRNTYLS
HHHHHHHCCHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEECCCCEEC
ASERKAALVLYRSLLTAKSLFAAKEYNPEIIRRKMTEEIQRESLAEIDYVSLSDQDTLGE
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
ADKVSIKTIALVAARFGKTRLIDNMFLA
CCHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MQKLHREICGPVGLVPTMGYLHEGHLSLIRASKKQDLNTVASIFVNPTQFGPHEDFKKYP
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCC
RDEKRDMAMLENAGVDYVFAPSVEEMYPPGFDSWVEPGVLQERLEGAVRPGHFRGVCTVV
CCHHHHHHHHHHCCCCEEECCCHHHHCCCCCCHHCCCHHHHHHHHCCCCCCCHHHHHHHH
AKLFTIICPAKAYFGQKDYQQYLIIKKMASDLNLDVSVEMLPIVRESDGLALSSRNTYLS
HHHHHHHCCHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEECCCCEEC
ASERKAALVLYRSLLTAKSLFAAKEYNPEIIRRKMTEEIQRESLAEIDYVSLSDQDTLGE
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
ADKVSIKTIALVAARFGKTRLIDNMFLA
CCHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA