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The map label for this gene is rnc

Identifier: 57234229

GI number: 57234229

Start: 931014

End: 931727

Strand: Direct

Name: rnc

Synonym: DET1025

Alternate gene names: 57234229

Gene position: 931014-931727 (Clockwise)

Preceding gene: 57234233

Following gene: 57234228

Centisome position: 63.35

GC content: 48.04

Gene sequence:

>714_bases
ATGTTAGATTTAACTGAACTTGAAAAATCCCTGGGAGTAAAGTTTGAAAATCTGTCCCTTTTGGAGCAGGCGCTCATACA
TACTTCATGGGTAAACGAAAACCCAAACCACTTAAGCGGCTCTAACGAAAGAATGGAATTTCTGGGTGATGCCGTACTGG
GTGTAATATTTGCAGACCGGCTTTACCATGATTTCCCTGATATTCAGGAAGGTGACCTGACCCGTTTCCGTTCCCTGCTG
GTGCGGCGGGAAAGTCTGGTAAGAGTAGCTTTGGGCATCAATCTTGGCAAATACCTCTATCTGGGGCGGGGTGAAGATGC
CTCCAAGGGGCGTTTTAAGCCGGCCAATCTGGCGGGTGCATTTGAAGCCGTGCTGGCAGCCATATATCTGGATAAAGGGA
TAGATGCAACCAGGGAAGTTATCTTCCGCCTTTTTAAGACCGAAATGGAACGGGTGCAAACCCTGAGTTCCAACATTGAT
TACAAATCACGCCTGCAGGAGCTTGTGCAAGCCCAATTTCAGCTTACACCCCGCTACCGTATTATAGATTTCAGCGGGCC
GGAACATAACCATCTGTTTATAGCCGAAGTCTATACCGAAGACAAAGTGCTGGCGGAAGGTTCGGGGCGCAGCAAAAAAG
AAGCCGAAACCAGCGCCGCTAAAGAAGCCTTGCAGCAGTTTGAAAACAGCTTTACAGCCGAAGATAACATTTGA

Upstream 100 bases:

>100_bases
TATCAGGACTATCATAAATGCTTTTTAATTTTAAGTCAAGAAAACCCTGCATTTGTTCCTGCTTGACATGTATTTGCCGA
ATGGCATAATCTTATCTGAA

Downstream 100 bases:

>100_bases
TAAACTTTTAGCATTGTAGGAGGACACGTATGGGTGGCAGAGATTTTCAATCACGCGAGACCAAAAAACAGAAGAAAGAT
TCCAAAAAACCGGCAGTTTC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MLDLTELEKSLGVKFENLSLLEQALIHTSWVNENPNHLSGSNERMEFLGDAVLGVIFADRLYHDFPDIQEGDLTRFRSLL
VRRESLVRVALGINLGKYLYLGRGEDASKGRFKPANLAGAFEAVLAAIYLDKGIDATREVIFRLFKTEMERVQTLSSNID
YKSRLQELVQAQFQLTPRYRIIDFSGPEHNHLFIAEVYTEDKVLAEGSGRSKKEAETSAAKEALQQFENSFTAEDNI

Sequences:

>Translated_237_residues
MLDLTELEKSLGVKFENLSLLEQALIHTSWVNENPNHLSGSNERMEFLGDAVLGVIFADRLYHDFPDIQEGDLTRFRSLL
VRRESLVRVALGINLGKYLYLGRGEDASKGRFKPANLAGAFEAVLAAIYLDKGIDATREVIFRLFKTEMERVQTLSSNID
YKSRLQELVQAQFQLTPRYRIIDFSGPEHNHLFIAEVYTEDKVLAEGSGRSKKEAETSAAKEALQQFENSFTAEDNI
>Mature_237_residues
MLDLTELEKSLGVKFENLSLLEQALIHTSWVNENPNHLSGSNERMEFLGDAVLGVIFADRLYHDFPDIQEGDLTRFRSLL
VRRESLVRVALGINLGKYLYLGRGEDASKGRFKPANLAGAFEAVLAAIYLDKGIDATREVIFRLFKTEMERVQTLSSNID
YKSRLQELVQAQFQLTPRYRIIDFSGPEHNHLFIAEVYTEDKVLAEGSGRSKKEAETSAAKEALQQFENSFTAEDNI

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788920, Length=228, Percent_Identity=34.2105263157895, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=235, Percent_Identity=31.4893617021277, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=239, Percent_Identity=31.7991631799163, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137682, Length=244, Percent_Identity=32.3770491803279, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17738129, Length=261, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_DEHE1 (Q3Z7Q8)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181741.1
- ProteinModelPortal:   Q3Z7Q8
- SMR:   Q3Z7Q8
- STRING:   Q3Z7Q8
- GeneID:   3229696
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1025
- NMPDR:   fig|243164.3.peg.594
- TIGR:   DET1025
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q3Z7Q8
- ProtClustDB:   CLSK837151
- BioCyc:   DETH243164:DET_1025-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26849; Mature: 26849

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLTELEKSLGVKFENLSLLEQALIHTSWVNENPNHLSGSNERMEFLGDAVLGVIFADR
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LYHDFPDIQEGDLTRFRSLLVRRESLVRVALGINLGKYLYLGRGEDASKGRFKPANLAGA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHH
FEAVLAAIYLDKGIDATREVIFRLFKTEMERVQTLSSNIDYKSRLQELVQAQFQLTPRYR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEE
IIDFSGPEHNHLFIAEVYTEDKVLAEGSGRSKKEAETSAAKEALQQFENSFTAEDNI
EEECCCCCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDLTELEKSLGVKFENLSLLEQALIHTSWVNENPNHLSGSNERMEFLGDAVLGVIFADR
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LYHDFPDIQEGDLTRFRSLLVRRESLVRVALGINLGKYLYLGRGEDASKGRFKPANLAGA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHH
FEAVLAAIYLDKGIDATREVIFRLFKTEMERVQTLSSNIDYKSRLQELVQAQFQLTPRYR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEE
IIDFSGPEHNHLFIAEVYTEDKVLAEGSGRSKKEAETSAAKEALQQFENSFTAEDNI
EEECCCCCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA