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The map label for this gene is cysK [H]

Identifier: 57234060

GI number: 57234060

Start: 1038336

End: 1039298

Strand: Direct

Name: cysK [H]

Synonym: DET1135

Alternate gene names: 57234060

Gene position: 1038336-1039298 (Clockwise)

Preceding gene: 57234090

Following gene: 57234058

Centisome position: 70.65

GC content: 52.86

Gene sequence:

>963_bases
ATGGATAATATAACGCCTGAGCATAATAAACATACCAACCAAAATATCGCTCCGGATATTACTAAACTTATAGGCAATAC
CCCGCTGGTGCGTCTGAACAGGATAGGCAGCGGGCTGAAAGCCGAAATTGTGCTGAAACTGGAATCATTTAATCCCACCC
ACAGTGCCAAAGACCGCCCCGCCCTGCATATGATAGAAAAGGCCGAGCAGGAAGGCAAGCTTCGCCCCGGAAGCATCATA
ATAGAATCCACCAGCGGCAATACCGGAATAGCCCTTGCCGCGGTTTGTGCCGCCAGAGGCTACCGCCTGATGCTGACCAT
GCCTGAAAGCTTCTCACTGGAAAGAAGGCGTTTGCTCCGCCTGCTGGGGGCGGAACTGGTACTTACCCCGAAAGAACTTG
GTATGCAGGGGGCTCTGGAAAAAGCAGCCGAACTCAAAAACAAGCTCCCAGAGACTTTTATACCCGGCCAGTTTGTAAAT
CCGGCTAATCCGGAAAGCCACTGCCAGACTACTGCCGCAGAAATCTGGCGGGATACAAACGGCAAAGTAGATATACTGAT
AGCGGGCGTAGGCACAGGCGGCACTCTAAGCGGCACAGCCAAAGGCCTAAAAGCAGTCAAACCTTCGGTACAGATAATAG
CGGTAGAACCGGTCGAATCACCGGTACTTTCAGGCGGAGAACCCCACCCCCATCTTATTCAGGGCATAGGGGCAGGCTTT
ATACCCCGCATACTTTCCGTGGAACTGATAGACAAAGTCATACAGGTGCCCGGAGAAGAAGCAGTGAAAATGGCACTCCG
CCTGGCGCGTGAAGAGGGTATTATGGCGGGTATTTCATCCGGGGCAGCACTCTGGGCAGCGCTGGAAACAGCTAAACAGG
GCGAAAACTGCGGCAAGCTTATTGTAGCCATTATGCCTGACAGCGGCGAACGCTATTTATCCAGCCTGCCGCTGGGTGAC
TGA

Upstream 100 bases:

>100_bases
GAATAAGGCTATTTTTAAAACATTCTTGACAAACTTGCGGCCATGCCCGACAATCCTATTTATACCGGGTTTTGAGTAGT
TACTCTGAAAGGGTCAGGGC

Downstream 100 bases:

>100_bases
AATCACTGCCCGGACAAGGCCTATAATCCAGCAGGCCCAAAAAAGTTCAGTCCGCTAAAAGGGGCTTACCGGACAGGGAA
TTTTCAGCCTATCCCAGAAT

Product: cysteine synthase A

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MDNITPEHNKHTNQNIAPDITKLIGNTPLVRLNRIGSGLKAEIVLKLESFNPTHSAKDRPALHMIEKAEQEGKLRPGSII
IESTSGNTGIALAAVCAARGYRLMLTMPESFSLERRRLLRLLGAELVLTPKELGMQGALEKAAELKNKLPETFIPGQFVN
PANPESHCQTTAAEIWRDTNGKVDILIAGVGTGGTLSGTAKGLKAVKPSVQIIAVEPVESPVLSGGEPHPHLIQGIGAGF
IPRILSVELIDKVIQVPGEEAVKMALRLAREEGIMAGISSGAALWAALETAKQGENCGKLIVAIMPDSGERYLSSLPLGD

Sequences:

>Translated_320_residues
MDNITPEHNKHTNQNIAPDITKLIGNTPLVRLNRIGSGLKAEIVLKLESFNPTHSAKDRPALHMIEKAEQEGKLRPGSII
IESTSGNTGIALAAVCAARGYRLMLTMPESFSLERRRLLRLLGAELVLTPKELGMQGALEKAAELKNKLPETFIPGQFVN
PANPESHCQTTAAEIWRDTNGKVDILIAGVGTGGTLSGTAKGLKAVKPSVQIIAVEPVESPVLSGGEPHPHLIQGIGAGF
IPRILSVELIDKVIQVPGEEAVKMALRLAREEGIMAGISSGAALWAALETAKQGENCGKLIVAIMPDSGERYLSSLPLGD
>Mature_320_residues
MDNITPEHNKHTNQNIAPDITKLIGNTPLVRLNRIGSGLKAEIVLKLESFNPTHSAKDRPALHMIEKAEQEGKLRPGSII
IESTSGNTGIALAAVCAARGYRLMLTMPESFSLERRRLLRLLGAELVLTPKELGMQGALEKAAELKNKLPETFIPGQFVN
PANPESHCQTTAAEIWRDTNGKVDILIAGVGTGGTLSGTAKGLKAVKPSVQIIAVEPVESPVLSGGEPHPHLIQGIGAGF
IPRILSVELIDKVIQVPGEEAVKMALRLAREEGIMAGISSGAALWAALETAKQGENCGKLIVAIMPDSGERYLSSLPLGD

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=326, Percent_Identity=42.3312883435583, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI295821200, Length=326, Percent_Identity=42.3312883435583, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI4557415, Length=326, Percent_Identity=42.3312883435583, Blast_Score=235, Evalue=3e-62,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=55.0955414012739, Blast_Score=283, Evalue=9e-78,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=41.5282392026578, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17535051, Length=295, Percent_Identity=51.5254237288136, Blast_Score=296, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=49.5049504950495, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=46.9798657718121, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=47.6351351351351, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17561720, Length=293, Percent_Identity=48.122866894198, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=209, Percent_Identity=46.4114832535885, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=36.741214057508, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=306, Percent_Identity=35.2941176470588, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=115, Percent_Identity=48.695652173913, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=36.7088607594937, Blast_Score=185, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=35.8433734939759, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=38.2911392405063, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=38.2911392405063, Blast_Score=201, Evalue=8e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34034; Mature: 34034

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNITPEHNKHTNQNIAPDITKLIGNTPLVRLNRIGSGLKAEIVLKLESFNPTHSAKDRP
CCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCH
ALHMIEKAEQEGKLRPGSIIIESTSGNTGIALAAVCAARGYRLMLTMPESFSLERRRLLR
HHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
LLGAELVLTPKELGMQGALEKAAELKNKLPETFIPGQFVNPANPESHCQTTAAEIWRDTN
HHCCCEEECHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GKVDILIAGVGTGGTLSGTAKGLKAVKPSVQIIAVEPVESPVLSGGEPHPHLIQGIGAGF
CCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHCCCHH
IPRILSVELIDKVIQVPGEEAVKMALRLAREEGIMAGISSGAALWAALETAKQGENCGKL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCEE
IVAIMPDSGERYLSSLPLGD
EEEEECCCCHHHHHCCCCCC
>Mature Secondary Structure
MDNITPEHNKHTNQNIAPDITKLIGNTPLVRLNRIGSGLKAEIVLKLESFNPTHSAKDRP
CCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCH
ALHMIEKAEQEGKLRPGSIIIESTSGNTGIALAAVCAARGYRLMLTMPESFSLERRRLLR
HHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
LLGAELVLTPKELGMQGALEKAAELKNKLPETFIPGQFVNPANPESHCQTTAAEIWRDTN
HHCCCEEECHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GKVDILIAGVGTGGTLSGTAKGLKAVKPSVQIIAVEPVESPVLSGGEPHPHLIQGIGAGF
CCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHCCCHH
IPRILSVELIDKVIQVPGEEAVKMALRLAREEGIMAGISSGAALWAALETAKQGENCGKL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCEE
IVAIMPDSGERYLSSLPLGD
EEEEECCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]