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The map label for this gene is copR [H]

Identifier: 57234028

GI number: 57234028

Start: 1128024

End: 1128701

Strand: Direct

Name: copR [H]

Synonym: DET1231

Alternate gene names: 57234028

Gene position: 1128024-1128701 (Clockwise)

Preceding gene: 57234030

Following gene: 57234017

Centisome position: 76.75

GC content: 41.74

Gene sequence:

>678_bases
ATGCTGATGAAACTGCTGTTAATCGAAGATGATGCCAATCTGGCAAAAGTCATTACTTCCGGTCTTGAAGAAAATGGATA
TGCAGTCAATTGGGAGTCCAATGGCAAACTTGGAGCTGAAATGGCTTTGGCCTATACCTTTGATGTCATCATCCTGGATA
TAATGCTGCCTGAACTTGATGGTTTCGCTGTATGCCATAAAATCCGCTCCAATGGCAATCAAACCCCCATCATAATGCTG
ACCGCCAGGTATCAGGAAGCTGACAAAGTAAATGGGCTTAACTGCGGAGCGGATGATTACCTGGTGAAACCTTTCAGCTT
CCCCGAACTGCTTGCCCGCCTGAGAGCCTTGCTAAGACGGGCCAATAACCAGCATTCTCCCTCTATCAAGCTCAGGAAAC
TTACTTTAAACACAGTGGACAGAAGAGCTTTTTACGATGGCAGGGAAATAGAGCTTACGGCTAAAGAATACGGCATTCTT
GAATATTTGGTACTGAACAAGAACTGCATAATTACCAAGAATATGATTGAAGAGCATATCTGGGAATCTGAAAGTGACAT
TTTTTCCAATGTCATAGAAGTGTTAATCAGCCGTATCCGCAAGAAACTGGACAACAATAATAAAAATTCTCTTATAAAAA
CGGTAAAAGGGTTAGGGTATATTATTGAGGATAAATAG

Upstream 100 bases:

>100_bases
TTTACAAACTTAATCTGAACTGAAAATGAATAACCCGGATAAACTTTCTACAAATGCAGACATTTTCGTTAATCTGCACC
CGGACTGAATGCTATAATAT

Downstream 100 bases:

>100_bases
CCTGCGAACTAAGTCAGCCGTCTTTTTCGCCGTTATCATCAGCTTTCAGACTGAAACAGCCTGATATATTTTTCTTAATA
GGCTTGTTAATTACCTGATT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MLMKLLLIEDDANLAKVITSGLEENGYAVNWESNGKLGAEMALAYTFDVIILDIMLPELDGFAVCHKIRSNGNQTPIIML
TARYQEADKVNGLNCGADDYLVKPFSFPELLARLRALLRRANNQHSPSIKLRKLTLNTVDRRAFYDGREIELTAKEYGIL
EYLVLNKNCIITKNMIEEHIWESESDIFSNVIEVLISRIRKKLDNNNKNSLIKTVKGLGYIIEDK

Sequences:

>Translated_225_residues
MLMKLLLIEDDANLAKVITSGLEENGYAVNWESNGKLGAEMALAYTFDVIILDIMLPELDGFAVCHKIRSNGNQTPIIML
TARYQEADKVNGLNCGADDYLVKPFSFPELLARLRALLRRANNQHSPSIKLRKLTLNTVDRRAFYDGREIELTAKEYGIL
EYLVLNKNCIITKNMIEEHIWESESDIFSNVIEVLISRIRKKLDNNNKNSLIKTVKGLGYIIEDK
>Mature_225_residues
MLMKLLLIEDDANLAKVITSGLEENGYAVNWESNGKLGAEMALAYTFDVIILDIMLPELDGFAVCHKIRSNGNQTPIIML
TARYQEADKVNGLNCGADDYLVKPFSFPELLARLRALLRRANNQHSPSIKLRKLTLNTVDRRAFYDGREIELTAKEYGIL
EYLVLNKNCIITKNMIEEHIWESESDIFSNVIEVLISRIRKKLDNNNKNSLIKTVKGLGYIIEDK

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.6396396396396, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=41.743119266055, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.9090909090909, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.4841628959276, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1790860, Length=217, Percent_Identity=32.258064516129, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=29.9107142857143, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=29.646017699115, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=30.6306306306306, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=29.1845493562232, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.0172413793103, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790437, Length=129, Percent_Identity=27.1317829457364, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790299, Length=131, Percent_Identity=29.7709923664122, Blast_Score=60, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=34.3137254901961, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25592; Mature: 25592

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKLLLIEDDANLAKVITSGLEENGYAVNWESNGKLGAEMALAYTFDVIILDIMLPELD
CEEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GFAVCHKIRSNGNQTPIIMLTARYQEADKVNGLNCGADDYLVKPFSFPELLARLRALLRR
HHHHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
ANNQHSPSIKLRKLTLNTVDRRAFYDGREIELTAKEYGILEYLVLNKNCIITKNMIEEHI
CCCCCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHHHCCEEEEEECCCEEEEHHHHHHHH
WESESDIFSNVIEVLISRIRKKLDNNNKNSLIKTVKGLGYIIEDK
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MLMKLLLIEDDANLAKVITSGLEENGYAVNWESNGKLGAEMALAYTFDVIILDIMLPELD
CEEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GFAVCHKIRSNGNQTPIIMLTARYQEADKVNGLNCGADDYLVKPFSFPELLARLRALLRR
HHHHHHHHHHCCCCCCEEEEEECCCCHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
ANNQHSPSIKLRKLTLNTVDRRAFYDGREIELTAKEYGILEYLVLNKNCIITKNMIEEHI
CCCCCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHHHCCEEEEEECCCEEEEHHHHHHHH
WESESDIFSNVIEVLISRIRKKLDNNNKNSLIKTVKGLGYIIEDK
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]