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The map label for this gene is coaE

Identifier: 57233957

GI number: 57233957

Start: 1201421

End: 1202017

Strand: Direct

Name: coaE

Synonym: DET1323

Alternate gene names: 57233957

Gene position: 1201421-1202017 (Clockwise)

Preceding gene: 57233972

Following gene: 57233955

Centisome position: 81.74

GC content: 50.25

Gene sequence:

>597_bases
ATGAAAATTGTAGGCATTACCGGTGGTATCGGCAGTGGCAAGACTACCGTTTGCCGTTATTTAAAGGAACTAGGGGTTAA
TATAATTGACGCCGACGAGATTGGCCACCGCGTACTCCAGAATAAAGGTATCCGCACCAGGATAACTGACGTTTTCGGCA
ATGAGGTCATGAACCCTGACGGGAGTATTAACCGCAAGATACTGGGCGAACTGGTCTTCGGATATCCCGAAAGGCTGGAG
CACCTGAATAAAATCACCCACCCCCTGATAGAACAGGCCATTGCTTCCCTGCTGGAAGAATACCGCCAAAAAGGCATAAA
AGCCGTAGCTATAGAAGCCCCCCTGCTGGTAGAGGCCGGCTGGTTAAAGCTGGTAAATGAAGTCTGGCTTATTACCGCTC
CCAAAGAAAGCATTTTCAAACGGCTGCGCAACCGTATGGGGCTGAGCCGCGAGCAGGTTATGGCCCGTATCCAGTCCCAG
GCCACTGATAATGAACGCCTCAAATACGCAAGTATTGTCATAAACAACAACTGCCGCTTTGAAGACCTGAAAAGCTGTGT
GCAGCTGCTGGCTAAGGAACGGCTGGAGCTGGCTTAA

Upstream 100 bases:

>100_bases
CTGCCTGCCAGCGAAATATGAAAATCTGTTCAGGACATCCAAAAGTATTTGAAGCCGGAATTTACTTGACCTGATTTTTT
TAAAAGACTAGACTAATTCA

Downstream 100 bases:

>100_bases
GGTAATCAAGCCCTTCCGAAAGAGGCTTGGGGTCAAAGCCGAACTCTGTCTTTACGGCATCTTCGGCAGTTATATTGTCT
ACCGACAAAGCTTTCAACTC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPDGSINRKILGELVFGYPERLE
HLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAGWLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQ
ATDNERLKYASIVINNNCRFEDLKSCVQLLAKERLELA

Sequences:

>Translated_198_residues
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPDGSINRKILGELVFGYPERLE
HLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAGWLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQ
ATDNERLKYASIVINNNCRFEDLKSCVQLLAKERLELA
>Mature_198_residues
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPDGSINRKILGELVFGYPERLE
HLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAGWLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQ
ATDNERLKYASIVINNNCRFEDLKSCVQLLAKERLELA

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI110227607, Length=177, Percent_Identity=33.8983050847458, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI110227605, Length=177, Percent_Identity=33.8983050847458, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227603, Length=177, Percent_Identity=33.8983050847458, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227601, Length=177, Percent_Identity=33.8983050847458, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI205277394, Length=177, Percent_Identity=33.8983050847458, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI191252797, Length=195, Percent_Identity=35.3846153846154, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI191252795, Length=195, Percent_Identity=35.3846153846154, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1786292, Length=197, Percent_Identity=36.5482233502538, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17554944, Length=191, Percent_Identity=32.4607329842932, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25143409, Length=193, Percent_Identity=29.0155440414508, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320402, Length=199, Percent_Identity=32.1608040201005, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644728, Length=187, Percent_Identity=32.620320855615, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24658602, Length=182, Percent_Identity=31.8681318681319, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_DEHE1 (Q3Z6W5)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182034.1
- ProteinModelPortal:   Q3Z6W5
- SMR:   Q3Z6W5
- STRING:   Q3Z6W5
- GeneID:   3229422
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1323
- NMPDR:   fig|243164.3.peg.487
- TIGR:   DET1323
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q3Z6W5
- ProtClustDB:   PRK00081
- BioCyc:   DETH243164:DET_1323-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22320; Mature: 22320

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPD
CEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GSINRKILGELVFGYPERLEHLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
WLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQATDNERLKYASIVINNNCRF
HHHHHHHHHEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCH
EDLKSCVQLLAKERLELA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPD
CEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GSINRKILGELVFGYPERLEHLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
WLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQATDNERLKYASIVINNNCRF
HHHHHHHHHEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEEEEEEEECCCCCH
EDLKSCVQLLAKERLELA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA