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The map label for this gene is typA [H]

Identifier: 57233898

GI number: 57233898

Start: 1182700

End: 1184529

Strand: Direct

Name: typA [H]

Synonym: DET1298

Alternate gene names: 57233898

Gene position: 1182700-1184529 (Clockwise)

Preceding gene: 57233901

Following gene: 57234003

Centisome position: 80.47

GC content: 50.22

Gene sequence:

>1830_bases
TTGGAAAACTACCAGAGAACCGATATCCGTAATATTGCTATTATTGCCCACGTAGACCACGGCAAAACCAGCCTGGTAGA
CGTGATGCTTAAACAAAGCCGCATTTTCCGTGAAAACCAGCACGTTGGCGAGCTTATTATGGACCGAAACACCCTTGAAC
GGGAAAAAGGCATTACTATTCTGGCCAAAAACACCGCCATAACCTACCGCGGAGTAAAGATAAACATCATTGATACTCCC
GGACATGCTGACTTTTCGGGTGAGGTTGAGCGGGTACTGAATATGGCAGACGGCTGTCTCTTGGTGATTGACAGTATAGA
CGGCCCTATGCCCCAAACCCGTTTTGTGCTTAAGGAAGCCATGCAGAAAAAGCTGAAGCCTATTGTAGTTATAAACAAGA
TAGACCGCGAAAATGCCCGCCCTGAAATAGTGCTGGGGCTGGTACAGGACTTGTTTCTGGAGCTGGCTACCACCGAGGAA
CAGCTGGACTTCCCGGTAGTTTATACCTCTGCCCGCGAAGGGTATGCCGTAAATACCCCCGGTACAAAAAGCACTGACCT
TATCCCCCTGTTTGAGTGCATACTGGATAAAATTCCCCCGCCCAGCATCGCCCAGGGTGAATTCCAAATGCTTATTTCCA
ACCTGGATTATGATACCCACAAAGGGCGGATAGCTATCGGGCGCATTCAGCGGGGTAAAATATGCTCCCATGACCGGGTA
GTTAATATAGATTCCCAAAATAAAGCTCACCCTTTTGAAGTGGGTCAGGTATTTACCTTTATGGGATTGGGCAAACAGGA
AGTGGAGTGTGCCGAAGCAGGTGAGATAGTAGCCATTACCGGTCTGGAAAACGCCTCAATAGGTGATACCGTCACCAGCC
CTCTCCAGCCTGAGGCCCTGCCCCGCATTGAAATAGGCGAACCTACTGTCAGAATGACTTTCGGGGTCAATACCTCACCT
TTCGGGGGGCGGGAAGGTAAATTCTGCACCTCACGCCAGCTTCGGGAAAGGCTTTTCCGTGAACTGGAGACCAATATAGG
GCTGAGGGTTGAGGAAACTGATTCGCCGGACTCATTTTTGATTTCCGGGCGGGGCGAACTCCACCTGTCCATCCTGGTAG
AGACCATGCGCCGCGAAGGGTATGAATTTGAAATATCCAAACCCGAAGCCATCACGAAAGATATAAACGGCAAAGTCTAT
GAGCCGGTGGAAACTCTGACGATAGATGTCCGCGAGGATTTTGTGGGAGAGGTCACCGAACTTCTGGGTAAACGCCAGGC
CCGCATGACTGATATGCACAATGACGGCGAAGGAAACGTAAGGCTGGAATATAACATACCCACCCGCGGTCTTATCGGCT
TCCGCAACTCGTTCCTGACAGCTACCAGAGGCACAGGCGTACTGAACAGCCAGTTTCTGGATTTTCAGCCCTGGTGCGGT
GAAATAGAGCAAAGCCGGACCGGCGCATTGGTGGCAGCCGAAGCAGGTTTGTCCTGCACTTACGGGCTTAATAACTCACA
GGAACGGGGCATACTGATGATAGATGCCAATGTACCTGTGTACGAGGGCATGATAGTCGGCCTGCATGCCAGAGGTCTTG
ACCTGGCAGTAAATGTCTGCAAGCAGAAAAAGATGACCAATATCCGTTCGTCTACTTCGGACATTGCCATAAAACTGGTG
CCGCCTATGAAACTCAGCCTTGAGCAATCTATGGATTTTATCGCCGAAGATGAGCTGGTTGAGGTCACTCCCAAAAGTAT
CCGCCTGCGGAAGAAGATACTGGATACCGAAATGAGACTTAGGGCTCGCAAACGCACTGAAAGTAATTAG

Upstream 100 bases:

>100_bases
ACCGACTGGTTTCTTCCGTTTAATTCCCGCTTTTTCATTCTTTTGTGATTTGCAGGGCGAAGTATGCCCTGGTAACCAGG
CTATTTTCAGGAGAAAGATT

Downstream 100 bases:

>100_bases
CCGTATTTGGGCTGATAGCCTTTACCAGGGGGCAATCTAAAGTTGCCCCTTTTGTATGAAACGAGGTGGGTTTAAGCAGC
GCAGACAGCTATCCGATACA

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MENYQRTDIRNIAIIAHVDHGKTSLVDVMLKQSRIFRENQHVGELIMDRNTLEREKGITILAKNTAITYRGVKINIIDTP
GHADFSGEVERVLNMADGCLLVIDSIDGPMPQTRFVLKEAMQKKLKPIVVINKIDRENARPEIVLGLVQDLFLELATTEE
QLDFPVVYTSAREGYAVNTPGTKSTDLIPLFECILDKIPPPSIAQGEFQMLISNLDYDTHKGRIAIGRIQRGKICSHDRV
VNIDSQNKAHPFEVGQVFTFMGLGKQEVECAEAGEIVAITGLENASIGDTVTSPLQPEALPRIEIGEPTVRMTFGVNTSP
FGGREGKFCTSRQLRERLFRELETNIGLRVEETDSPDSFLISGRGELHLSILVETMRREGYEFEISKPEAITKDINGKVY
EPVETLTIDVREDFVGEVTELLGKRQARMTDMHNDGEGNVRLEYNIPTRGLIGFRNSFLTATRGTGVLNSQFLDFQPWCG
EIEQSRTGALVAAEAGLSCTYGLNNSQERGILMIDANVPVYEGMIVGLHARGLDLAVNVCKQKKMTNIRSSTSDIAIKLV
PPMKLSLEQSMDFIAEDELVEVTPKSIRLRKKILDTEMRLRARKRTESN

Sequences:

>Translated_609_residues
MENYQRTDIRNIAIIAHVDHGKTSLVDVMLKQSRIFRENQHVGELIMDRNTLEREKGITILAKNTAITYRGVKINIIDTP
GHADFSGEVERVLNMADGCLLVIDSIDGPMPQTRFVLKEAMQKKLKPIVVINKIDRENARPEIVLGLVQDLFLELATTEE
QLDFPVVYTSAREGYAVNTPGTKSTDLIPLFECILDKIPPPSIAQGEFQMLISNLDYDTHKGRIAIGRIQRGKICSHDRV
VNIDSQNKAHPFEVGQVFTFMGLGKQEVECAEAGEIVAITGLENASIGDTVTSPLQPEALPRIEIGEPTVRMTFGVNTSP
FGGREGKFCTSRQLRERLFRELETNIGLRVEETDSPDSFLISGRGELHLSILVETMRREGYEFEISKPEAITKDINGKVY
EPVETLTIDVREDFVGEVTELLGKRQARMTDMHNDGEGNVRLEYNIPTRGLIGFRNSFLTATRGTGVLNSQFLDFQPWCG
EIEQSRTGALVAAEAGLSCTYGLNNSQERGILMIDANVPVYEGMIVGLHARGLDLAVNVCKQKKMTNIRSSTSDIAIKLV
PPMKLSLEQSMDFIAEDELVEVTPKSIRLRKKILDTEMRLRARKRTESN
>Mature_609_residues
MENYQRTDIRNIAIIAHVDHGKTSLVDVMLKQSRIFRENQHVGELIMDRNTLEREKGITILAKNTAITYRGVKINIIDTP
GHADFSGEVERVLNMADGCLLVIDSIDGPMPQTRFVLKEAMQKKLKPIVVINKIDRENARPEIVLGLVQDLFLELATTEE
QLDFPVVYTSAREGYAVNTPGTKSTDLIPLFECILDKIPPPSIAQGEFQMLISNLDYDTHKGRIAIGRIQRGKICSHDRV
VNIDSQNKAHPFEVGQVFTFMGLGKQEVECAEAGEIVAITGLENASIGDTVTSPLQPEALPRIEIGEPTVRMTFGVNTSP
FGGREGKFCTSRQLRERLFRELETNIGLRVEETDSPDSFLISGRGELHLSILVETMRREGYEFEISKPEAITKDINGKVY
EPVETLTIDVREDFVGEVTELLGKRQARMTDMHNDGEGNVRLEYNIPTRGLIGFRNSFLTATRGTGVLNSQFLDFQPWCG
EIEQSRTGALVAAEAGLSCTYGLNNSQERGILMIDANVPVYEGMIVGLHARGLDLAVNVCKQKKMTNIRSSTSDIAIKLV
PPMKLSLEQSMDFIAEDELVEVTPKSIRLRKKILDTEMRLRARKRTESN

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=323, Percent_Identity=31.2693498452012, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI94966754, Length=135, Percent_Identity=41.4814814814815, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4503483, Length=148, Percent_Identity=35.1351351351351, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI18390331, Length=142, Percent_Identity=40.8450704225352, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI25306287, Length=133, Percent_Identity=38.3458646616541, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI19923640, Length=133, Percent_Identity=38.3458646616541, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI25306283, Length=133, Percent_Identity=38.3458646616541, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=37.5, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=38.0530973451327, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=38.0530973451327, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=38.0530973451327, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI94966752, Length=130, Percent_Identity=32.3076923076923, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI34147630, Length=274, Percent_Identity=27.3722627737226, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI48994988, Length=600, Percent_Identity=52.5, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1788922, Length=536, Percent_Identity=28.7313432835821, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1789738, Length=139, Percent_Identity=38.1294964028777, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790835, Length=150, Percent_Identity=30.6666666666667, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790412, Length=261, Percent_Identity=27.2030651340996, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789737, Length=261, Percent_Identity=27.2030651340996, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=320, Percent_Identity=31.25, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556745, Length=445, Percent_Identity=25.6179775280899, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=178, Percent_Identity=34.8314606741573, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71988811, Length=129, Percent_Identity=40.3100775193798, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=129, Percent_Identity=40.3100775193798, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=139, Percent_Identity=41.726618705036, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=32.089552238806, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17556456, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994658, Length=132, Percent_Identity=36.3636363636364, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=513, Percent_Identity=25.7309941520468, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=185, Percent_Identity=37.8378378378378, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=185, Percent_Identity=37.8378378378378, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322359, Length=163, Percent_Identity=38.0368098159509, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=154, Percent_Identity=37.012987012987, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323098, Length=143, Percent_Identity=39.1608391608392, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=229, Percent_Identity=29.6943231441048, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324550, Length=171, Percent_Identity=32.1637426900585, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78706572, Length=510, Percent_Identity=25.0980392156863, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI28574573, Length=141, Percent_Identity=37.5886524822695, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=36.3636363636364, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=36.3636363636364, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=36.3636363636364, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24582462, Length=143, Percent_Identity=41.2587412587413, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=38.8059701492537, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221458488, Length=163, Percent_Identity=39.2638036809816, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363316, Length=231, Percent_Identity=30.7359307359307, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17864358, Length=231, Percent_Identity=30.7359307359307, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921738, Length=232, Percent_Identity=30.1724137931034, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68061; Mature: 68061

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENYQRTDIRNIAIIAHVDHGKTSLVDVMLKQSRIFRENQHVGELIMDRNTLEREKGITI
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCEE
LAKNTAITYRGVKINIIDTPGHADFSGEVERVLNMADGCLLVIDSIDGPMPQTRFVLKEA
EEECCEEEEECEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
MQKKLKPIVVINKIDRENARPEIVLGLVQDLFLELATTEEQLDFPVVYTSAREGYAVNTP
HHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCEEECCC
GTKSTDLIPLFECILDKIPPPSIAQGEFQMLISNLDYDTHKGRIAIGRIQRGKICSHDRV
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCE
VNIDSQNKAHPFEVGQVFTFMGLGKQEVECAEAGEIVAITGLENASIGDTVTSPLQPEAL
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCC
PRIEIGEPTVRMTFGVNTSPFGGREGKFCTSRQLRERLFRELETNIGLRVEETDSPDSFL
CCEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
ISGRGELHLSILVETMRREGYEFEISKPEAITKDINGKVYEPVETLTIDVREDFVGEVTE
EECCCCEEHHHHHHHHHHCCCEEEECCCCHHHHCCCCCEECCCEEEEEEHHHHHHHHHHH
LLGKRQARMTDMHNDGEGNVRLEYNIPTRGLIGFRNSFLTATRGTGVLNSQFLDFQPWCG
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCC
EIEQSRTGALVAAEAGLSCTYGLNNSQERGILMIDANVPVYEGMIVGLHARGLDLAVNVC
CHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHH
KQKKMTNIRSSTSDIAIKLVPPMKLSLEQSMDFIAEDELVEVTPKSIRLRKKILDTEMRL
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
RARKRTESN
HHHHCCCCC
>Mature Secondary Structure
MENYQRTDIRNIAIIAHVDHGKTSLVDVMLKQSRIFRENQHVGELIMDRNTLEREKGITI
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCEE
LAKNTAITYRGVKINIIDTPGHADFSGEVERVLNMADGCLLVIDSIDGPMPQTRFVLKEA
EEECCEEEEECEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
MQKKLKPIVVINKIDRENARPEIVLGLVQDLFLELATTEEQLDFPVVYTSAREGYAVNTP
HHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCEEEECCCCCEEECCC
GTKSTDLIPLFECILDKIPPPSIAQGEFQMLISNLDYDTHKGRIAIGRIQRGKICSHDRV
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCE
VNIDSQNKAHPFEVGQVFTFMGLGKQEVECAEAGEIVAITGLENASIGDTVTSPLQPEAL
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCC
PRIEIGEPTVRMTFGVNTSPFGGREGKFCTSRQLRERLFRELETNIGLRVEETDSPDSFL
CCEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEE
ISGRGELHLSILVETMRREGYEFEISKPEAITKDINGKVYEPVETLTIDVREDFVGEVTE
EECCCCEEHHHHHHHHHHCCCEEEECCCCHHHHCCCCCEECCCEEEEEEHHHHHHHHHHH
LLGKRQARMTDMHNDGEGNVRLEYNIPTRGLIGFRNSFLTATRGTGVLNSQFLDFQPWCG
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCC
EIEQSRTGALVAAEAGLSCTYGLNNSQERGILMIDANVPVYEGMIVGLHARGLDLAVNVC
CHHCCCCCEEEEECCCCEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHH
KQKKMTNIRSSTSDIAIKLVPPMKLSLEQSMDFIAEDELVEVTPKSIRLRKKILDTEMRL
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHH
RARKRTESN
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]