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The map label for this gene is gpsA

Identifier: 57233848

GI number: 57233848

Start: 1263733

End: 1264812

Strand: Direct

Name: gpsA

Synonym: DET1397

Alternate gene names: 57233848

Gene position: 1263733-1264812 (Clockwise)

Preceding gene: 57233849

Following gene: 57233843

Centisome position: 85.98

GC content: 53.24

Gene sequence:

>1080_bases
ATGTCTAAAGTTTGTATTATAGGCACTACTACCTGGGGCATTACCCTGGGTACGGTCATAGCCCATAAAGGGCGCGAAGT
AATGCTCTGGGCACGCACCGAGGACGAAGCCGCACTTCTCTCAGCCCAGCGCCGTCCGGCTGATTTTTTGCCGGAAGATT
ATTATTTCCCCGAATACCTGAACGTAACCGCCAGTTTGGAGGAAGCCCTATCCGGAGCAGACATGGTTCTTATGGCTGTG
CCTTCCCAGCGGATGCGCCCCAATATACGGCTGGCTGCACCTTTGCTGACTAAAAACATGCTGGTCTGCAGCGCCTCCAA
GGGGCTGGAAATAGGTACTGCCAAGCGTATGAGCCAGGTAATTGCCGACGAGATTTCCCCGGATTTTTCCCAGAATATAT
GTGTTCTTTCGGGGCCGAATCTGGCTATGGAAATACTAAAGGGGCTGCCGGCTGTAACTGTACTGGCTGCCGATACTGAA
AAGACGGCTAAAAAAGCCGCCAAACTGGTAACCGCCAGTAACTTTTGCGCTTACACCAATACGGATATCATAGGGGTGGA
GCTGGGCGGCTCACTCAAGAATATTATCGCTCTGGGGGCAGGCATAGCGGACGGGCTGAGCTTCGGCAACAATGCCAAGA
GCGCCCTGATTACCCGCGGCCTTACCGAGATTTCCGCCCTGGGGGCGGCTTTGGGGGCAAACCCTCTGACATTTTCGGGT
CTGGCCGGACTGGGTGACCTGATTGCCACCTGTTCCAGCAACCTGTCACGCAACCATTTTGTGGGGGTGGAATTAACCAA
AGGCCGCAGCCTGAATGACATTATGTACAGCATGAGCAATGTAGCCGAAGGTGTTTCCACTACCGCAGTAGCCTATGAGC
TGGCCCGCTCTATGGATTTGGAAATGCCGGTAACCGAAAACATTTACAACGTGCTTTATAATAACGCAGACCCGAAGGAA
GCCGCCAGAAAACTGATGGCTGCCCAGGCTGCCCATGAACTGGCCGGACGCAAGTGGGATTTGTTTAAAATGTTCCGCAG
GCGCAGAACCCGCAAAACACCTGAACTTAATCCGGATTAG

Upstream 100 bases:

>100_bases
TAAACGGCTTTTAGCGGGTAAAGAACGCAAGCTCAACGAAAAATCCCGTTAAACACCCCTTGTCTAAAACCAATCCGGCA
TTAGAAAGCTTAGGTTTTTC

Downstream 100 bases:

>100_bases
AAAACTTAAAGACCGGCTACTTTTTATCCTCGGCGAAAGACTTCTCCAGCTCCTCAAAGAGCTGTTTCTGTTTACGGCTG
AGCTTCTCAGGAGTAACAAC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSKVCIIGTTTWGITLGTVIAHKGREVMLWARTEDEAALLSAQRRPADFLPEDYYFPEYLNVTASLEEALSGADMVLMAV
PSQRMRPNIRLAAPLLTKNMLVCSASKGLEIGTAKRMSQVIADEISPDFSQNICVLSGPNLAMEILKGLPAVTVLAADTE
KTAKKAAKLVTASNFCAYTNTDIIGVELGGSLKNIIALGAGIADGLSFGNNAKSALITRGLTEISALGAALGANPLTFSG
LAGLGDLIATCSSNLSRNHFVGVELTKGRSLNDIMYSMSNVAEGVSTTAVAYELARSMDLEMPVTENIYNVLYNNADPKE
AARKLMAAQAAHELAGRKWDLFKMFRRRRTRKTPELNPD

Sequences:

>Translated_359_residues
MSKVCIIGTTTWGITLGTVIAHKGREVMLWARTEDEAALLSAQRRPADFLPEDYYFPEYLNVTASLEEALSGADMVLMAV
PSQRMRPNIRLAAPLLTKNMLVCSASKGLEIGTAKRMSQVIADEISPDFSQNICVLSGPNLAMEILKGLPAVTVLAADTE
KTAKKAAKLVTASNFCAYTNTDIIGVELGGSLKNIIALGAGIADGLSFGNNAKSALITRGLTEISALGAALGANPLTFSG
LAGLGDLIATCSSNLSRNHFVGVELTKGRSLNDIMYSMSNVAEGVSTTAVAYELARSMDLEMPVTENIYNVLYNNADPKE
AARKLMAAQAAHELAGRKWDLFKMFRRRRTRKTPELNPD
>Mature_358_residues
SKVCIIGTTTWGITLGTVIAHKGREVMLWARTEDEAALLSAQRRPADFLPEDYYFPEYLNVTASLEEALSGADMVLMAVP
SQRMRPNIRLAAPLLTKNMLVCSASKGLEIGTAKRMSQVIADEISPDFSQNICVLSGPNLAMEILKGLPAVTVLAADTEK
TAKKAAKLVTASNFCAYTNTDIIGVELGGSLKNIIALGAGIADGLSFGNNAKSALITRGLTEISALGAALGANPLTFSGL
AGLGDLIATCSSNLSRNHFVGVELTKGRSLNDIMYSMSNVAEGVSTTAVAYELARSMDLEMPVTENIYNVLYNNADPKEA
ARKLMAAQAAHELAGRKWDLFKMFRRRRTRKTPELNPD

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=340, Percent_Identity=26.4705882352941, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33695088, Length=333, Percent_Identity=26.7267267267267, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790037, Length=327, Percent_Identity=39.7553516819572, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17507425, Length=362, Percent_Identity=26.7955801104972, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564399, Length=340, Percent_Identity=25.5882352941176, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564403, Length=347, Percent_Identity=25.0720461095101, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193210136, Length=347, Percent_Identity=25.0720461095101, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193210134, Length=329, Percent_Identity=24.9240121580547, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324513, Length=344, Percent_Identity=27.906976744186, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320181, Length=346, Percent_Identity=24.8554913294798, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136204, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136202, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136200, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551945, Length=334, Percent_Identity=23.9520958083832, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI22026922, Length=352, Percent_Identity=22.1590909090909, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281362270, Length=234, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_DEHE1 (Q3Z6P3)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182106.1
- ProteinModelPortal:   Q3Z6P3
- STRING:   Q3Z6P3
- GeneID:   3229312
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1397
- NMPDR:   fig|243164.3.peg.1350
- TIGR:   DET1397
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q3Z6P3
- ProtClustDB:   PRK00094
- BioCyc:   DETH243164:DET_1397-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 38493; Mature: 38362

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 193-193 BINDING 107-107 BINDING 107-107 BINDING 142-142 BINDING 257-257 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVCIIGTTTWGITLGTVIAHKGREVMLWARTEDEAALLSAQRRPADFLPEDYYFPEYL
CCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHH
NVTASLEEALSGADMVLMAVPSQRMRPNIRLAAPLLTKNMLVCSASKGLEIGTAKRMSQV
HHHHHHHHHCCCCCEEEEECCHHHHCCCCEEECHHHHCCEEEEECCCCCCCCHHHHHHHH
IADEISPDFSQNICVLSGPNLAMEILKGLPAVTVLAADTEKTAKKAAKLVTASNFCAYTN
HHHHCCCCCCCCEEEEECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECC
TDIIGVELGGSLKNIIALGAGIADGLSFGNNAKSALITRGLTEISALGAALGANPLTFSG
CCEEEEECCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAGLGDLIATCSSNLSRNHFVGVELTKGRSLNDIMYSMSNVAEGVSTTAVAYELARSMDL
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EMPVTENIYNVLYNNADPKEAARKLMAAQAAHELAGRKWDLFKMFRRRRTRKTPELNPD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SKVCIIGTTTWGITLGTVIAHKGREVMLWARTEDEAALLSAQRRPADFLPEDYYFPEYL
CCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHH
NVTASLEEALSGADMVLMAVPSQRMRPNIRLAAPLLTKNMLVCSASKGLEIGTAKRMSQV
HHHHHHHHHCCCCCEEEEECCHHHHCCCCEEECHHHHCCEEEEECCCCCCCCHHHHHHHH
IADEISPDFSQNICVLSGPNLAMEILKGLPAVTVLAADTEKTAKKAAKLVTASNFCAYTN
HHHHCCCCCCCCEEEEECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECC
TDIIGVELGGSLKNIIALGAGIADGLSFGNNAKSALITRGLTEISALGAALGANPLTFSG
CCEEEEECCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAGLGDLIATCSSNLSRNHFVGVELTKGRSLNDIMYSMSNVAEGVSTTAVAYELARSMDL
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EMPVTENIYNVLYNNADPKEAARKLMAAQAAHELAGRKWDLFKMFRRRRTRKTPELNPD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA