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The map label for this gene is glcK [H]

Identifier: 57233593

GI number: 57233593

Start: 40831

End: 41841

Strand: Direct

Name: glcK [H]

Synonym: DET0049

Alternate gene names: 57233593

Gene position: 40831-41841 (Clockwise)

Preceding gene: 57233594

Following gene: 57233592

Centisome position: 2.78

GC content: 56.38

Gene sequence:

>1011_bases
GTGAACCGGAGTAATTTAGAGGCCATACTTAAGCCCTGTTTGTGCCTGGATATAGGCGGCAGTAAAATCCGCTCGGCGGT
AGTGACCCATGACGGACGGGTGGTGGCCTGGGAACAGGAGCCTACCTGCGCCCGGAACGGGGCGGAGGGTGTATTTGAGA
ATATCTGCCGGGTGCTTGAGCGCCTGCTTGAGCGTAACAACCTTTGTATCTCCCAGTTTGAGGCCCTGTCTGCGGCGGTA
GCCGGGGGTATAGATATGCCAAACGGACTGGTTACCCAGTCTCCCCATCTGCCCGTCTGGCGGGATGTACCCCTTCGGGA
TATGCTGGCAGAGCGTTATCTTAAAACATTCCTTATAAATGATGCCTCGGCCGCCGCTTTGGCCGAACACAAACTGGGAG
CGGGGCGGGGGGTTAAAAACCTGGTTTACCTGACGGTCTCTACCGGTATCGGGGGCGGTATTATTATAAATGATGAGCTT
TATCTGGGGCAGAGCGGCTGTGCCGGTGAAATAGGGCATATGTGTCTGGATATAAACGGCACTGAAGATGTCTGCGGCAA
TGTGGGCTGTCTGGAAACGCTGGCTTCGGGTACGGCTATTGTCCGCAGGGTTCAGGCCGAACTTGCCGGGGGTGAGTTTT
CCCTGCTTTCAGAGCGGTTTAAGGCGGATTACTCCGCTTTGACGGCTGAGGATATCGGCCGGGCGGCTTCCGAAGGTGAC
AGGCTGTGCCAGGGGGTTATCCGCCGGGCAGGCGAATATTTGGGAATAGGTCTGGCCGGTATTGCCAATATATTTAACCC
TGAGCTTATTATACTGGGGGGTGGGGTTTCCAAACTGGGGGAGATTTTTATTGAGCCTGCCCGCAAAATGCTTTTCAAAC
GGGCTTTCCGTCTGGCGGGGGATGATGTCCGGCTGGTTGCTTCGTTTCTGGGGGATAATGCCGGGGTGACCGGGGCGGCA
CTTTATGCCTACGGCTGCCTGGGGGGCGGGGGTAAACCTTCTCAGGGCTGA

Upstream 100 bases:

>100_bases
CAAGTATATTGTGATGGTGTATGCCGGAATAGGCCTGATAGACTGGCTGCCTTTCCTGAAGAGCTAGGTGCTTGTTTAGC
TTTAAAAGTAAGGGGGCTTT

Downstream 100 bases:

>100_bases
ACGGGTGTTATATATAATATAGAAGACCCCCTGTCTCTTTATTAAAATTGACAGTATAACGGGCTTAAACTAAAATCGTA
TTTATCTTATCTATCTTGAA

Product: ROK family protein

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNRSNLEAILKPCLCLDIGGSKIRSAVVTHDGRVVAWEQEPTCARNGAEGVFENICRVLERLLERNNLCISQFEALSAAV
AGGIDMPNGLVTQSPHLPVWRDVPLRDMLAERYLKTFLINDASAAALAEHKLGAGRGVKNLVYLTVSTGIGGGIIINDEL
YLGQSGCAGEIGHMCLDINGTEDVCGNVGCLETLASGTAIVRRVQAELAGGEFSLLSERFKADYSALTAEDIGRAASEGD
RLCQGVIRRAGEYLGIGLAGIANIFNPELIILGGGVSKLGEIFIEPARKMLFKRAFRLAGDDVRLVASFLGDNAGVTGAA
LYAYGCLGGGGKPSQG

Sequences:

>Translated_336_residues
MNRSNLEAILKPCLCLDIGGSKIRSAVVTHDGRVVAWEQEPTCARNGAEGVFENICRVLERLLERNNLCISQFEALSAAV
AGGIDMPNGLVTQSPHLPVWRDVPLRDMLAERYLKTFLINDASAAALAEHKLGAGRGVKNLVYLTVSTGIGGGIIINDEL
YLGQSGCAGEIGHMCLDINGTEDVCGNVGCLETLASGTAIVRRVQAELAGGEFSLLSERFKADYSALTAEDIGRAASEGD
RLCQGVIRRAGEYLGIGLAGIANIFNPELIILGGGVSKLGEIFIEPARKMLFKRAFRLAGDDVRLVASFLGDNAGVTGAA
LYAYGCLGGGGKPSQG
>Mature_336_residues
MNRSNLEAILKPCLCLDIGGSKIRSAVVTHDGRVVAWEQEPTCARNGAEGVFENICRVLERLLERNNLCISQFEALSAAV
AGGIDMPNGLVTQSPHLPVWRDVPLRDMLAERYLKTFLINDASAAALAEHKLGAGRGVKNLVYLTVSTGIGGGIIINDEL
YLGQSGCAGEIGHMCLDINGTEDVCGNVGCLETLASGTAIVRRVQAELAGGEFSLLSERFKADYSALTAEDIGRAASEGD
RLCQGVIRRAGEYLGIGLAGIANIFNPELIILGGGVSKLGEIFIEPARKMLFKRAFRLAGDDVRLVASFLGDNAGVTGAA
LYAYGCLGGGGKPSQG

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=277, Percent_Identity=33.2129963898917, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4885285, Length=277, Percent_Identity=33.2129963898917, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI298566325, Length=277, Percent_Identity=33.2129963898917, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI298566315, Length=299, Percent_Identity=31.7725752508361, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI298566312, Length=116, Percent_Identity=35.3448275862069, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786891, Length=299, Percent_Identity=28.4280936454849, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787878, Length=281, Percent_Identity=26.3345195729537, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787363, Length=317, Percent_Identity=25.5520504731861, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081733, Length=317, Percent_Identity=26.4984227129338, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082127, Length=210, Percent_Identity=27.6190476190476, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082230, Length=266, Percent_Identity=31.9548872180451, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 35397; Mature: 35397

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSNLEAILKPCLCLDIGGSKIRSAVVTHDGRVVAWEQEPTCARNGAEGVFENICRVLE
CCCCHHHHHHHHHHEEECCCHHHHHHHEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHH
RLLERNNLCISQFEALSAAVAGGIDMPNGLVTQSPHLPVWRDVPLRDMLAERYLKTFLIN
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
DASAAALAEHKLGAGRGVKNLVYLTVSTGIGGGIIINDELYLGQSGCAGEIGHMCLDING
CCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEECCEEEECCCCCCCCCCCEEEECCC
TEDVCGNVGCLETLASGTAIVRRVQAELAGGEFSLLSERFKADYSALTAEDIGRAASEGD
CHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLCQGVIRRAGEYLGIGLAGIANIFNPELIILGGGVSKLGEIFIEPARKMLFKRAFRLAG
HHHHHHHHHCHHHHCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
DDVRLVASFLGDNAGVTGAALYAYGCLGGGGKPSQG
CHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNRSNLEAILKPCLCLDIGGSKIRSAVVTHDGRVVAWEQEPTCARNGAEGVFENICRVLE
CCCCHHHHHHHHHHEEECCCHHHHHHHEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHH
RLLERNNLCISQFEALSAAVAGGIDMPNGLVTQSPHLPVWRDVPLRDMLAERYLKTFLIN
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
DASAAALAEHKLGAGRGVKNLVYLTVSTGIGGGIIINDELYLGQSGCAGEIGHMCLDING
CCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEECCEEEECCCCCCCCCCCEEEECCC
TEDVCGNVGCLETLASGTAIVRRVQAELAGGEFSLLSERFKADYSALTAEDIGRAASEGD
CHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLCQGVIRRAGEYLGIGLAGIANIFNPELIILGGGVSKLGEIFIEPARKMLFKRAFRLAG
HHHHHHHHHCHHHHCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
DDVRLVASFLGDNAGVTGAALYAYGCLGGGGKPSQG
CHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]