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The map label for this gene is Hgd [H]

Identifier: 56965569

GI number: 56965569

Start: 3972460

End: 3973311

Strand: Direct

Name: Hgd [H]

Synonym: ABC3811

Alternate gene names: 56965569

Gene position: 3972460-3973311 (Clockwise)

Preceding gene: 56965568

Following gene: 56965570

Centisome position: 92.3

GC content: 48.71

Gene sequence:

>852_bases
ATGAAAACAGTTGGTCTTATTGGCTGTGGCGCCATGGGAAAAGGGATGGCTACGTCCCTTTTGAGCGCCGGCTATACCGT
TTATATTTATGACGACATGTCCAAATGGCGAGAACCATTGGAAAAACAAGGAGCATGCTTTGTGGAAAACAGCGCTGCTG
TAGCAAAAAAGGCAAAGTATGTCTTGCTATCTCTCCCTTCACCGAACATAGTTGCCGACACCGTTGCAGGCAAAGAAGGC
GTGCTTTGTCATTTACAAACGGGTGGCTTTTTATTAGATCTGAGCACGACAGATGTGCAAACGACATTAGCGATGGAAAA
AGCCGCTGCTGCCAAAGGAATTTATTACCTAGACTGCCCTGTCAGCGGGGGGCCTGCTGGAGCTGATGCCGGAACGCTAA
CAATCATGGTTGGCGGCGACAAACAAGCTTACTTCAGTGTAAAACCGCTACTTGACATACTCGGCGATACCATTCTGTAT
GTGGGCGATTCTGGGGCCGGGCAAACGGTCAAACTGTGCAACAACATGCTTGTTGCCGGGATTACGACGCTGCTGAGCGA
AACAATGGCGGTTGCTAGCGACCATGGCGTATCTAGACGGCTTCTTGCCCAAATCATCCAACAAAGTTCTGGCCATAATC
GCGTCCTTGACGTTTTTGGGGAAAATTTAATTTCCGGCTCATACGACAATGTGTTGTTCTACTTAAAGCATATGGCTAAA
GATCTTGAACTCTACATGGCATTGTCGCAAGATTCGCGCAAACCCCAGCATGCTGCTGGCACTGTCAACCAGCTCTACCG
CTCAGCGCTTCATCAAGGCAAAGGCGATAAAGACGCCACTGCTGTTTACTAA

Upstream 100 bases:

>100_bases
CAAGAAAAATTCGAGTATTGGGCCGAGGGAACAAGGAAGCACTGCCCTTGACTTTTGGGTTGATACAAAAGCAGTCTATC
TTAAACCTTAGGAGGTAGTG

Downstream 100 bases:

>100_bases
TTACCTGGAAATGATTCTGCACCATCGATTTCCCTGTTCATAAGAAAGGCGGGAACTATGAATAAACAAAAACGTTTCCT
CACCGACTGGCGACTTCACT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKYVLLSLPSPNIVADTVAGKEG
VLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCPVSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILY
VGDSGAGQTVKLCNNMLVAGITTLLSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVFGENLISGSYDNVLFYLKHMAK
DLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAVY

Sequences:

>Translated_283_residues
MKTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKYVLLSLPSPNIVADTVAGKEG
VLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCPVSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILY
VGDSGAGQTVKLCNNMLVAGITTLLSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVFGENLISGSYDNVLFYLKHMAK
DLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAVY
>Mature_283_residues
MKTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKYVLLSLPSPNIVADTVAGKEG
VLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCPVSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILY
VGDSGAGQTVKLCNNMLVAGITTLLSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVFGENLISGSYDNVLFYLKHMAK
DLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAVY

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=32.6388888888889, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=28.0141843971631, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI1786719, Length=279, Percent_Identity=30.4659498207885, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693186, Length=243, Percent_Identity=30.4526748971193, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=25.4416961130742, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=27.972027972028, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788341, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=276, Percent_Identity=31.5217391304348, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=30.6896551724138, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=30.6896551724138, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=22.1830985915493, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 29941; Mature: 29941

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKY
CCCEEEEECCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEECCHHHHHCCCE
VLLSLPSPNIVADTVAGKEGVLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCP
EEEECCCCCEEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHCCEEEEECC
VSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILYVGDSGAGQTVKLCNNMLVAG
CCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
ITTLLSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVFGENLISGSYDNVLFYLKHMAK
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
DLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAVY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKY
CCCEEEEECCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEECCHHHHHCCCE
VLLSLPSPNIVADTVAGKEGVLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCP
EEEECCCCCEEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHCCEEEEECC
VSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILYVGDSGAGQTVKLCNNMLVAG
CCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
ITTLLSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVFGENLISGSYDNVLFYLKHMAK
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
DLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAVY
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA