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The map label for this gene is lytC [H]

Identifier: 56965057

GI number: 56965057

Start: 3421698

End: 3422552

Strand: Direct

Name: lytC [H]

Synonym: ABC3295

Alternate gene names: 56965057

Gene position: 3421698-3422552 (Clockwise)

Preceding gene: 56965055

Following gene: 56965066

Centisome position: 79.5

GC content: 46.43

Gene sequence:

>855_bases
ATGAAATGCAATCAAATGACACTTTGTCTTTTCTTTTTTATCGTATTCGCGCTTTCTTCAGTTGTGATTTCTGAAGATGT
GCATGCCATAGCAGCAAAAACAGGAGAAGTCGATACACAAACTTCTTTAAATGTCCGTAGCGGACCGAGCACGAGCCACG
AAGTTGTCGGATCGCTGACACCTGGCGAACAAGTGGCGTATACCGACAACGGCGATGGCTGGGGCGAGCTAGTCGACGGC
AGTGGTTATATCAGCCTTCATTATATTACCAATCACGATGGAGAACCTGTCGACCGGAGCAGCGCCAAACATGACAGTGT
CCCGTTAAACAATGAACGGATTGTGTTGGACCCTGGGCACGGGGGGAAAGATAGCGGAGCTGTAGCGAACGGTTTAATGG
AAAAAGAAATTGTATTGGATATCGGCAAACGAACACGTGATATTTTAGAAAATGCTGGCTTTGCCGTATTGATGACACGA
GACGAAGATGTATTTGTCAGCTTAGAAGAGAGAACAGCAATGGCAAACGCTTGGGGAGCTGACCAGTTTATTAGCATACA
TGCAAATGGGTTCTCTAACCCAGCTGCAAATGGTGTCGAAACTTATTATTTCCCGGGAAGTGCAGCAGGCAAGCATATGG
CCGCTAATGTCCAAAACCAATTAGTTGAACACACAGATCGAACCGACCGTGGCATTTTTGAGGAAAGCTTTTATGTCATT
AGCCATACAACCATGCCAGCTATTCTGGTGGAAACAGGTTTTGTGTCGAATGCTGACGACGCGAGCCAACTTGCGGATGC
CAATTATCGACAAACAGTGGCAGAAGCGATTGCGAACAGCGTTATCGATGACTAG

Upstream 100 bases:

>100_bases
TTAGCCAACTTCCTGCGCTTTCTTTCTATGAATCTGTTTATTTTTTCTACTAGATGGCTAGACTGCTAAGGCAGGGTTAC
TTAGACAGGAGGTATTTTTT

Downstream 100 bases:

>100_bases
TACCCGTATACTGCTGTGTCGGCGACAATAACAATCAACGGACTCCCCAGTGCAGTGTGTCATCGTTGTCGTCGACATCA
CCGGACAAATGCGTCCTATT

Product: hypothetical protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKCNQMTLCLFFFIVFALSSVVISEDVHAIAAKTGEVDTQTSLNVRSGPSTSHEVVGSLTPGEQVAYTDNGDGWGELVDG
SGYISLHYITNHDGEPVDRSSAKHDSVPLNNERIVLDPGHGGKDSGAVANGLMEKEIVLDIGKRTRDILENAGFAVLMTR
DEDVFVSLEERTAMANAWGADQFISIHANGFSNPAANGVETYYFPGSAAGKHMAANVQNQLVEHTDRTDRGIFEESFYVI
SHTTMPAILVETGFVSNADDASQLADANYRQTVAEAIANSVIDD

Sequences:

>Translated_284_residues
MKCNQMTLCLFFFIVFALSSVVISEDVHAIAAKTGEVDTQTSLNVRSGPSTSHEVVGSLTPGEQVAYTDNGDGWGELVDG
SGYISLHYITNHDGEPVDRSSAKHDSVPLNNERIVLDPGHGGKDSGAVANGLMEKEIVLDIGKRTRDILENAGFAVLMTR
DEDVFVSLEERTAMANAWGADQFISIHANGFSNPAANGVETYYFPGSAAGKHMAANVQNQLVEHTDRTDRGIFEESFYVI
SHTTMPAILVETGFVSNADDASQLADANYRQTVAEAIANSVIDD
>Mature_284_residues
MKCNQMTLCLFFFIVFALSSVVISEDVHAIAAKTGEVDTQTSLNVRSGPSTSHEVVGSLTPGEQVAYTDNGDGWGELVDG
SGYISLHYITNHDGEPVDRSSAKHDSVPLNNERIVLDPGHGGKDSGAVANGLMEKEIVLDIGKRTRDILENAGFAVLMTR
DEDVFVSLEERTAMANAWGADQFISIHANGFSNPAANGVETYYFPGSAAGKHMAANVQNQLVEHTDRTDRGIFEESFYVI
SHTTMPAILVETGFVSNADDASQLADANYRQTVAEAIANSVIDD

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=219, Percent_Identity=32.8767123287671, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87082163, Length=211, Percent_Identity=33.175355450237, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790611, Length=215, Percent_Identity=26.5116279069767, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 30546; Mature: 30546

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCNQMTLCLFFFIVFALSSVVISEDVHAIAAKTGEVDTQTSLNVRSGPSTSHEVVGSLT
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHEECCC
PGEQVAYTDNGDGWGELVDGSGYISLHYITNHDGEPVDRSSAKHDSVPLNNERIVLDPGH
CCCEEEEECCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GGKDSGAVANGLMEKEIVLDIGKRTRDILENAGFAVLMTRDEDVFVSLEERTAMANAWGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHCCCCC
DQFISIHANGFSNPAANGVETYYFPGSAAGKHMAANVQNQLVEHTDRTDRGIFEESFYVI
CEEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCEEEE
SHTTMPAILVETGFVSNADDASQLADANYRQTVAEAIANSVIDD
EECCCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKCNQMTLCLFFFIVFALSSVVISEDVHAIAAKTGEVDTQTSLNVRSGPSTSHEVVGSLT
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHEECCC
PGEQVAYTDNGDGWGELVDGSGYISLHYITNHDGEPVDRSSAKHDSVPLNNERIVLDPGH
CCCEEEEECCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GGKDSGAVANGLMEKEIVLDIGKRTRDILENAGFAVLMTRDEDVFVSLEERTAMANAWGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHCCCCC
DQFISIHANGFSNPAANGVETYYFPGSAAGKHMAANVQNQLVEHTDRTDRGIFEESFYVI
CEEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCEEEE
SHTTMPAILVETGFVSNADDASQLADANYRQTVAEAIANSVIDD
EECCCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]