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The map label for this gene is galK [H]

Identifier: 56964983

GI number: 56964983

Start: 3340225

End: 3341403

Strand: Direct

Name: galK [H]

Synonym: ABC3219

Alternate gene names: 56964983

Gene position: 3340225-3341403 (Clockwise)

Preceding gene: 56964975

Following gene: 56964984

Centisome position: 77.61

GC content: 47.67

Gene sequence:

>1179_bases
ATGAACACGAATGAGCTTGCCGCTGAATTTGAAACGATTTTTGGCTCTTTGCCAGACCAGCTTTTTTTCGCGCCAGGACG
TGTGAACTTGATTGGCGAACATACCGATTACAATGGTGGTTTTGTCTTTCCCGCCGCTTTAACAATGGGCACTTACTTAG
CAGTCCGCCGCACAAACACCAATGAATTTCGTTTAGCGAGCCAAAATTTTAGCCAACGGGTTGCTTTCCCAAACAAAGAA
CTTTCGTACAATAAAGAAGATGATTGGGGCAATTATCCTAAAGGCGTGATCGCTTATTTTCAACATCATGGCTTTGATTT
AGGCGGCGCCGATCTTTATTTTTTTGGAAACATCCCCAATGGGGCAGGATTGTCTTCTTCAGCCTCGATCGAGATGGTGA
CAGCCTATATGATCTCTTCCCTTACAGGCGCCAATTGGGATCGCCTCGACCTTGTAAAAGCATGCCAGCATGTTGAAAAC
AACTTTATCGGTGTGAACAGCGGCATTATGGACCAATTTGCTGTGGGCATGGGCAAAGCTGACCATGCGCTTTTTTTGCA
AACGGACTCGTTGCAGTACGAACTTGTGCCATTAACATTGGGCAATTACGATATCGTGATTACCAATTCAAATAAACGCA
GAGGGCTAGCTGACTCCAAATACAATGAACGACGGGCCGAGTGTGAACAAGCGCTCGCTGACCTTCAAGCAGCTGGTCTT
GACATTCGTACATTAAGTGATGTCACACCAGCGTTGCTCGCAAAACACCACCACGCTTTCTCGACGGCGACAGTTGCCAA
ACGAGCTAGCCATGTTGTCAGCGAAAACCAACGTGTGCTTGAAGCCGTAACAGCGCTAAAAGCAGGAAACCTCCGTGACT
TCGGGCAACTGATGAATGAATCTCATCAATCGCTGGCAAACGATTACGAAGTGACTGGCTTAGAGCTTGATGCGTTATAT
CAGTTGCAACACCGGGCCCCTGGCTGCATCGGCACACGAATGACTGGAGCAGGATTTGGCGGCTGTACTGTCAGCCTTGT
ACAAACAGACAAAATGGAAGCGTTTCAAGCACACGTTAAAAAAGGCTACGAAAGCGAATTTGGCTTTCAACCAAGCTTCT
ATATTAGCCGCGCCGGTGATGGCGTAACCGAACTGCCTTTGGCCACTGCGGCAGATTGA

Upstream 100 bases:

>100_bases
TGTTATTGTTCGTTTTTGTTGATATAATCATAGAAAGTTTTGCAACCGCTGTCAAATCACACTTGCTTATCTGTCTTTTT
ACGTTAAAAGGAGTGACTCT

Downstream 100 bases:

>100_bases
GGTTCAACCAGATGAAAAAACAGATTTACACACAAATTGAAAAATTGCTTGCTTACGGCGTTCAAAAAAAACTGCTCCCT
CTTGCTGATGTGGACTATAG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNTNELAAEFETIFGSLPDQLFFAPGRVNLIGEHTDYNGGFVFPAALTMGTYLAVRRTNTNEFRLASQNFSQRVAFPNKE
LSYNKEDDWGNYPKGVIAYFQHHGFDLGGADLYFFGNIPNGAGLSSSASIEMVTAYMISSLTGANWDRLDLVKACQHVEN
NFIGVNSGIMDQFAVGMGKADHALFLQTDSLQYELVPLTLGNYDIVITNSNKRRGLADSKYNERRAECEQALADLQAAGL
DIRTLSDVTPALLAKHHHAFSTATVAKRASHVVSENQRVLEAVTALKAGNLRDFGQLMNESHQSLANDYEVTGLELDALY
QLQHRAPGCIGTRMTGAGFGGCTVSLVQTDKMEAFQAHVKKGYESEFGFQPSFYISRAGDGVTELPLATAAD

Sequences:

>Translated_392_residues
MNTNELAAEFETIFGSLPDQLFFAPGRVNLIGEHTDYNGGFVFPAALTMGTYLAVRRTNTNEFRLASQNFSQRVAFPNKE
LSYNKEDDWGNYPKGVIAYFQHHGFDLGGADLYFFGNIPNGAGLSSSASIEMVTAYMISSLTGANWDRLDLVKACQHVEN
NFIGVNSGIMDQFAVGMGKADHALFLQTDSLQYELVPLTLGNYDIVITNSNKRRGLADSKYNERRAECEQALADLQAAGL
DIRTLSDVTPALLAKHHHAFSTATVAKRASHVVSENQRVLEAVTALKAGNLRDFGQLMNESHQSLANDYEVTGLELDALY
QLQHRAPGCIGTRMTGAGFGGCTVSLVQTDKMEAFQAHVKKGYESEFGFQPSFYISRAGDGVTELPLATAAD
>Mature_392_residues
MNTNELAAEFETIFGSLPDQLFFAPGRVNLIGEHTDYNGGFVFPAALTMGTYLAVRRTNTNEFRLASQNFSQRVAFPNKE
LSYNKEDDWGNYPKGVIAYFQHHGFDLGGADLYFFGNIPNGAGLSSSASIEMVTAYMISSLTGANWDRLDLVKACQHVEN
NFIGVNSGIMDQFAVGMGKADHALFLQTDSLQYELVPLTLGNYDIVITNSNKRRGLADSKYNERRAECEQALADLQAAGL
DIRTLSDVTPALLAKHHHAFSTATVAKRASHVVSENQRVLEAVTALKAGNLRDFGQLMNESHQSLANDYEVTGLELDALY
QLQHRAPGCIGTRMTGAGFGGCTVSLVQTDKMEAFQAHVKKGYESEFGFQPSFYISRAGDGVTELPLATAAD

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=394, Percent_Identity=39.3401015228426, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4503897, Length=437, Percent_Identity=28.8329519450801, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI48527957, Length=437, Percent_Identity=28.8329519450801, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1786972, Length=375, Percent_Identity=37.0666666666667, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71989053, Length=436, Percent_Identity=28.6697247706422, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319494, Length=272, Percent_Identity=30.1470588235294, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=190, Percent_Identity=32.1052631578947, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24661292, Length=441, Percent_Identity=26.3038548752834, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21355577, Length=441, Percent_Identity=26.3038548752834, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24661285, Length=441, Percent_Identity=26.3038548752834, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42840; Mature: 42840

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNELAAEFETIFGSLPDQLFFAPGRVNLIGEHTDYNGGFVFPAALTMGTYLAVRRTNT
CCCHHHHHHHHHHHCCCCHHHEECCCCEEEEECCCCCCCCEEHHHHHHHHHEEEEEECCC
NEFRLASQNFSQRVAFPNKELSYNKEDDWGNYPKGVIAYFQHHGFDLGGADLYFFGNIPN
CCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GAGLSSSASIEMVTAYMISSLTGANWDRLDLVKACQHVENNFIGVNSGIMDQFAVGMGKA
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCC
DHALFLQTDSLQYELVPLTLGNYDIVITNSNKRRGLADSKYNERRAECEQALADLQAAGL
CCEEEEEECCCEEEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DIRTLSDVTPALLAKHHHAFSTATVAKRASHVVSENQRVLEAVTALKAGNLRDFGQLMNE
CEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SHQSLANDYEVTGLELDALYQLQHRAPGCIGTRMTGAGFGGCTVSLVQTDKMEAFQAHVK
HHHHHHCCCEECCEEHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHH
KGYESEFGFQPSFYISRAGDGVTELPLATAAD
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTNELAAEFETIFGSLPDQLFFAPGRVNLIGEHTDYNGGFVFPAALTMGTYLAVRRTNT
CCCHHHHHHHHHHHCCCCHHHEECCCCEEEEECCCCCCCCEEHHHHHHHHHEEEEEECCC
NEFRLASQNFSQRVAFPNKELSYNKEDDWGNYPKGVIAYFQHHGFDLGGADLYFFGNIPN
CCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GAGLSSSASIEMVTAYMISSLTGANWDRLDLVKACQHVENNFIGVNSGIMDQFAVGMGKA
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCC
DHALFLQTDSLQYELVPLTLGNYDIVITNSNKRRGLADSKYNERRAECEQALADLQAAGL
CCEEEEEECCCEEEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DIRTLSDVTPALLAKHHHAFSTATVAKRASHVVSENQRVLEAVTALKAGNLRDFGQLMNE
CEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SHQSLANDYEVTGLELDALYQLQHRAPGCIGTRMTGAGFGGCTVSLVQTDKMEAFQAHVK
HHHHHHCCCEECCEEHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHH
KGYESEFGFQPSFYISRAGDGVTELPLATAAD
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]