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The map label for this gene is aceA [H]

Identifier: 56964737

GI number: 56964737

Start: 3092762

End: 3094033

Strand: Direct

Name: aceA [H]

Synonym: ABC2973

Alternate gene names: 56964737

Gene position: 3092762-3094033 (Clockwise)

Preceding gene: 56964715

Following gene: 56964756

Centisome position: 71.86

GC content: 49.21

Gene sequence:

>1272_bases
ATGCTAGAAGAAAAACAACTCGTAGAAAGCTGGGAGCATGAAGAACGCTGGAAAGGGATCATAAGGCCGTATGAGGCTGC
TGATGTTATGCGGCTAAGGGGCACGCTCGAGATTGAATACACAATTGCCAGGCGCGGTGCCGAAAAGCTGTGGAAACTTC
TCCATACAGAGGATTTCGTCCCAGCGCTAGGCGCTTTAACTGGAAACCAAGCGATGCAGCAAGTAAAAGCCGGATTGAAA
GCGATTTATTTAAGCGGTTGGCAAGTGGCTGCTGATGCCAATTTGGCAGGGAGTATGTATCCTGATCAAAGCCTTTATCC
GGCAAACAGCGTACCCGAAGTCGTCAAAAAAATCAACCGTACGCTGCAACGCGCGGATCAAATTTCCCACATGGAAGGAA
AAGAAGACATCGATTGGTATGCCCCAATTGTGGCCGATGCGGAGGCAGGCTTTGGTGGACAGCTAAATGTGTTCGAGTTA
ATGAAAAGCATGATTGAAGCAGGCGCCGCAGGAGTTCACTTTGAAGATCAGCTATCTTCTGAGAAAAAGTGCGGGCATTT
AGGCGGAAAAGTGCTGCTTCCGACGCAAACAGCAGTACGTAATTTGATTGCCGCCCGTCTCGCAGCAGACGTGATGGGAG
TACCGACCATTCTTATTGCTCGTACAGATGCCAATGCCGCTGACCTAATCACAAGCGACGTCGATTCATATGATGCACCG
TTTTTAACGGGAGAACGAACAGCGGAAGGGTTTTTCAAAACAAAGTCAGGTCTTGATCAGGCGATTGCGAGAGGCTTAGC
GTATGCGCCGTATGCTGATTTAATCTGGTGTGAAACGTCTGAGCCAAATATTGAAGAAGCACGTCGGTTCGCACAAGCGA
TCCACGAGAAATTCCCAGGCAAACTGCTCGCCTACAATTGCTCCCCTTCGTTTAACTGGAAAGCCAAACTGGATGACCAC
ACCATTTTAAACTTCCAGAAACAACTCGGTGAAATGGGCTATAAATTTCAATTTGTCACACTGGCCGGCTTCCACGCCTT
AAACCACGGCATGTTTGAATTATCCCGCCAATATAAGGACCGCGGAATGGCGGCGTACTCTGATCTTCAGCAGGCTGAAT
TTGCCAGTGAAGCCCACGGCTACACGGCAACAAGGCATCAGCGCGAAGTCGGCACAAGCTACTTTGATGAAGTTGCCCAA
GTCGTAACAGGCGGGACTTCATCGACCACTGCCCTGAAGGGATCGACTGAAGCGGAACAGTTTCAATCTTAA

Upstream 100 bases:

>100_bases
CTAAACGGAGGACGCAACGATGACACGTTTTGATAATGGCAGGATAGTTAATTGGGCAGCTGAAGCTAGATGAAAAAACG
TATAATTGGGGGAATGTGCG

Downstream 100 bases:

>100_bases
AAACGTGAAAAAGCCGCCCGTTAATGGGTGGCTTACTTGTGGTCTAGCAGAATAGCAATTGACATCTTGGCCAGGTCATC
GTATTTTACCAAGGGAAATC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLEEKQLVESWEHEERWKGIIRPYEAADVMRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANLAGSMYPDQSLYPANSVPEVVKKINRTLQRADQISHMEGKEDIDWYAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKSGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDH
TILNFQKQLGEMGYKFQFVTLAGFHALNHGMFELSRQYKDRGMAAYSDLQQAEFASEAHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS

Sequences:

>Translated_423_residues
MLEEKQLVESWEHEERWKGIIRPYEAADVMRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANLAGSMYPDQSLYPANSVPEVVKKINRTLQRADQISHMEGKEDIDWYAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKSGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDH
TILNFQKQLGEMGYKFQFVTLAGFHALNHGMFELSRQYKDRGMAAYSDLQQAEFASEAHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS
>Mature_423_residues
MLEEKQLVESWEHEERWKGIIRPYEAADVMRLRGTLEIEYTIARRGAEKLWKLLHTEDFVPALGALTGNQAMQQVKAGLK
AIYLSGWQVAADANLAGSMYPDQSLYPANSVPEVVKKINRTLQRADQISHMEGKEDIDWYAPIVADAEAGFGGQLNVFEL
MKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
FLTGERTAEGFFKTKSGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPGKLLAYNCSPSFNWKAKLDDH
TILNFQKQLGEMGYKFQFVTLAGFHALNHGMFELSRQYKDRGMAAYSDLQQAEFASEAHGYTATRHQREVGTSYFDEVAQ
VVTGGTSSTTALKGSTEAEQFQS

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=427, Percent_Identity=65.1053864168618, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1786525, Length=262, Percent_Identity=27.8625954198473, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982926, Length=415, Percent_Identity=64.578313253012, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17561814, Length=415, Percent_Identity=64.578313253012, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6320908, Length=324, Percent_Identity=37.3456790123457, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325263, Length=259, Percent_Identity=37.4517374517375, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46778; Mature: 46778

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEEKQLVESWEHEERWKGIIRPYEAADVMRLRGTLEIEYTIARRGAEKLWKLLHTEDFV
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHH
PALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLAGSMYPDQSLYPANSVPEVVKKINR
HHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLQRADQISHMEGKEDIDWYAPIVADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQLSS
HHHHHHHHHHCCCCCCCCHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
EKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
HHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCC
FLTGERTAEGFFKTKSGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPG
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KLLAYNCSPSFNWKAKLDDHTILNFQKQLGEMGYKFQFVTLAGFHALNHGMFELSRQYKD
CEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
RGMAAYSDLQQAEFASEAHGYTATRHQREVGTSYFDEVAQVVTGGTSSTTALKGSTEAEQ
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
FQS
HCC
>Mature Secondary Structure
MLEEKQLVESWEHEERWKGIIRPYEAADVMRLRGTLEIEYTIARRGAEKLWKLLHTEDFV
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHH
PALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLAGSMYPDQSLYPANSVPEVVKKINR
HHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLQRADQISHMEGKEDIDWYAPIVADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQLSS
HHHHHHHHHHCCCCCCCCHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
EKKCGHLGGKVLLPTQTAVRNLIAARLAADVMGVPTILIARTDANAADLITSDVDSYDAP
HHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCC
FLTGERTAEGFFKTKSGLDQAIARGLAYAPYADLIWCETSEPNIEEARRFAQAIHEKFPG
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KLLAYNCSPSFNWKAKLDDHTILNFQKQLGEMGYKFQFVTLAGFHALNHGMFELSRQYKD
CEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHH
RGMAAYSDLQQAEFASEAHGYTATRHQREVGTSYFDEVAQVVTGGTSSTTALKGSTEAEQ
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
FQS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]