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The map label for this gene is vraR [H]

Identifier: 56963890

GI number: 56963890

Start: 2246338

End: 2246952

Strand: Direct

Name: vraR [H]

Synonym: ABC2125

Alternate gene names: 56963890

Gene position: 2246338-2246952 (Clockwise)

Preceding gene: 56963889

Following gene: 56963895

Centisome position: 52.19

GC content: 46.34

Gene sequence:

>615_bases
ATGAACATTCTTATTGTTGATGACGATGCGCTCGTTTGCCAGAGTCTCGAACTGCTTCTTGGCAACGAAGATGATTTTAC
TGTCGTAGGCACTGCCAACAATGGCCGTGAAGCACTTGTACAAATAGAGAAAAAAGCGCCTGACCTCGTATTGATGGATA
TTCGCATGCCCGAAATGGATGGCATTGAAAGTACAAAAGAAATCAAAAGCCGCTGGCCAGAAATGTTAATTATGATGCTA
ACAACGTTCCAAGATGAACAAAACATTCGCCTCGCTTTGCAGGCTGGAGCAGAAGGGTATTTGCTCAAATCGACAGCGGT
AGCCAATATGGCCAAGCAAATCCGTGCCTTAAGCGCCGGTTCATCTGTACTGGACGCCGATGTGCTCAAGCAATTGGTGA
AACCCCATGCCGACGCCCTCGCCGGATTAACAAAGCGGGAAAGTGAGATTGCCGAATGCATTGCCCAAGGGCTTTCAAAC
AAAGAAATTGCAGCCCATCTATTTTTAAGTGTCGGTACTGTACGGAATACACTCTCTGTCATTCTTGACAAGCTCGAACT
GCGGGATCGCACCCAACTGGCGATCTACTATTGGAAACATCAAACAAACAGATAA

Upstream 100 bases:

>100_bases
AAATCCGTGCACGCGCCGCTGGCGGGAGCTTGTCTGTAAATCGCTCATCGGGCTATTCGATTGTTTGTGTCCTGCCAATC
CAAGAAAGGAAAGATGCGAG

Downstream 100 bases:

>100_bases
TAGGCGTGGGCCAACTTCAATAGAAGACTCTGTGTTGTGTTTCATACAAAAAAAGCGCAGGGCTGTCCCCTGCACTTTTA
GTCCGTAGTTAACGCTTGTC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MNILIVDDDALVCQSLELLLGNEDDFTVVGTANNGREALVQIEKKAPDLVLMDIRMPEMDGIESTKEIKSRWPEMLIMML
TTFQDEQNIRLALQAGAEGYLLKSTAVANMAKQIRALSAGSSVLDADVLKQLVKPHADALAGLTKRESEIAECIAQGLSN
KEIAAHLFLSVGTVRNTLSVILDKLELRDRTQLAIYYWKHQTNR

Sequences:

>Translated_204_residues
MNILIVDDDALVCQSLELLLGNEDDFTVVGTANNGREALVQIEKKAPDLVLMDIRMPEMDGIESTKEIKSRWPEMLIMML
TTFQDEQNIRLALQAGAEGYLLKSTAVANMAKQIRALSAGSSVLDADVLKQLVKPHADALAGLTKRESEIAECIAQGLSN
KEIAAHLFLSVGTVRNTLSVILDKLELRDRTQLAIYYWKHQTNR
>Mature_204_residues
MNILIVDDDALVCQSLELLLGNEDDFTVVGTANNGREALVQIEKKAPDLVLMDIRMPEMDGIESTKEIKSRWPEMLIMML
TTFQDEQNIRLALQAGAEGYLLKSTAVANMAKQIRALSAGSSVLDADVLKQLVKPHADALAGLTKRESEIAECIAQGLSN
KEIAAHLFLSVGTVRNTLSVILDKLELRDRTQLAIYYWKHQTNR

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=32.3076923076923, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788222, Length=206, Percent_Identity=30.5825242718447, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=29.126213592233, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787473, Length=207, Percent_Identity=32.3671497584541, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=37.007874015748, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=26.6331658291457, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=24.6305418719212, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=102, Percent_Identity=40.1960784313725, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082052, Length=133, Percent_Identity=32.3308270676692, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=102, Percent_Identity=37.2549019607843, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22621; Mature: 22621

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIVDDDALVCQSLELLLGNEDDFTVVGTANNGREALVQIEKKAPDLVLMDIRMPEMD
CEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHEEHHCCCCCEEEEEECCCCCC
GIESTKEIKSRWPEMLIMMLTTFQDEQNIRLALQAGAEGYLLKSTAVANMAKQIRALSAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCC
SSVLDADVLKQLVKPHADALAGLTKRESEIAECIAQGLSNKEIAAHLFLSVGTVRNTLSV
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ILDKLELRDRTQLAIYYWKHQTNR
HHHHHHCCCCCEEEEEEEECCCCC
>Mature Secondary Structure
MNILIVDDDALVCQSLELLLGNEDDFTVVGTANNGREALVQIEKKAPDLVLMDIRMPEMD
CEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHEEHHCCCCCEEEEEECCCCCC
GIESTKEIKSRWPEMLIMMLTTFQDEQNIRLALQAGAEGYLLKSTAVANMAKQIRALSAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCC
SSVLDADVLKQLVKPHADALAGLTKRESEIAECIAQGLSNKEIAAHLFLSVGTVRNTLSV
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ILDKLELRDRTQLAIYYWKHQTNR
HHHHHHCCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]