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The map label for this gene is pip [H]

Identifier: 56963739

GI number: 56963739

Start: 2088061

End: 2089014

Strand: Direct

Name: pip [H]

Synonym: ABC1974

Alternate gene names: 56963739

Gene position: 2088061-2089014 (Clockwise)

Preceding gene: 56963738

Following gene: 56963740

Centisome position: 48.52

GC content: 43.4

Gene sequence:

>954_bases
ATGAATACATATATAGTACGAGGCAAAAAAATCCATGTAGAGATTTTCGGAGATCGGTCACTACCGGCTGTGCTTTTTCT
TCATGGCGGGCCTGGAGAAAGCTGCTACGAATTTGTTTATCATCAGTCCAACCGTTTTTCAGATCAATTTCAATTGGTAG
CGATTGACCAAAGAGGGGTTTGCCGCTCGGAAGGTTTATCAGAAACTGAACCATTCGGGCTTCAAGATTTAGTGGAAGAC
TGTGAGGATTTGAGGAAACAACTGGGCATTAACCGATGGGCAGTCATTGGCCATTCGTTTGGTGGGTATCTTGCTTTGCT
TTATGCCTCAGTTTATCCAAACGCTATCACAAACGTTGTTTTTGAATGTCCAACCTTTGACTTTGCATGGACGGCAAAAA
GTTTGTTGCGCAGAGCAGCTTCTGTCTTTTTAGAGCTAGGAATCGAAACGAAATCCGAGGAATGTCTAAATCTAGCAACC
AGCAACTTATCAAGTGAGCACCTATTTGATTCGTATTTACGCCTAGGAGAGGAGCTAGGGGAACATAAAGAGGATATTTA
CCGGGTAAATGCCGATACTTCAATAGATTATTCGGCATATACGGATGAAGAATGGGAGGCTTTTGATGACCGAACGGACA
TTCATCTTGAGCGTTTACGAGAAGAGGGAAGGATCTTCCAATCGATCGTCTCCTTGCTTCCCAGTCTTTCGGTTCCTTCT
TTGCTTGTGATAGGGGACGCGGACCCAGTCACATGCGATAAACATGTGGAAGCTTATAATCAAATGGCAAACGGTCATAA
AGTGGTGATGAACAATTGTGGGCATACTCCCCATGCCGAATGTCCAGATGTCTATTATCGAATTGTGTCTGCGTTTTTGT
TACAGGGTGAATGGCGCTTTGTAGAAATGGGCAATGGAGCATACACGTACTTTAACAAGGATGTGAGTAAATAA

Upstream 100 bases:

>100_bases
ATTATATCCGCTAATTTTATTGACTCGGGCCTTTTCACCGCAAATAATAAGTATAGGCCACACAATACGAATGATTGCAT
GTGAAGAAGGAGCCACAATC

Downstream 100 bases:

>100_bases
TGGTTTTTCATGCGAAAATAGCGATTGTTCCTATGATTATATTTATATTTTTATTGGTAGGCGCCATGGTCGCGATGGCT
GTTTTTCCTCTCACTTTTAT

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MNTYIVRGKKIHVEIFGDRSLPAVLFLHGGPGESCYEFVYHQSNRFSDQFQLVAIDQRGVCRSEGLSETEPFGLQDLVED
CEDLRKQLGINRWAVIGHSFGGYLALLYASVYPNAITNVVFECPTFDFAWTAKSLLRRAASVFLELGIETKSEECLNLAT
SNLSSEHLFDSYLRLGEELGEHKEDIYRVNADTSIDYSAYTDEEWEAFDDRTDIHLERLREEGRIFQSIVSLLPSLSVPS
LLVIGDADPVTCDKHVEAYNQMANGHKVVMNNCGHTPHAECPDVYYRIVSAFLLQGEWRFVEMGNGAYTYFNKDVSK

Sequences:

>Translated_317_residues
MNTYIVRGKKIHVEIFGDRSLPAVLFLHGGPGESCYEFVYHQSNRFSDQFQLVAIDQRGVCRSEGLSETEPFGLQDLVED
CEDLRKQLGINRWAVIGHSFGGYLALLYASVYPNAITNVVFECPTFDFAWTAKSLLRRAASVFLELGIETKSEECLNLAT
SNLSSEHLFDSYLRLGEELGEHKEDIYRVNADTSIDYSAYTDEEWEAFDDRTDIHLERLREEGRIFQSIVSLLPSLSVPS
LLVIGDADPVTCDKHVEAYNQMANGHKVVMNNCGHTPHAECPDVYYRIVSAFLLQGEWRFVEMGNGAYTYFNKDVSK
>Mature_317_residues
MNTYIVRGKKIHVEIFGDRSLPAVLFLHGGPGESCYEFVYHQSNRFSDQFQLVAIDQRGVCRSEGLSETEPFGLQDLVED
CEDLRKQLGINRWAVIGHSFGGYLALLYASVYPNAITNVVFECPTFDFAWTAKSLLRRAASVFLELGIETKSEECLNLAT
SNLSSEHLFDSYLRLGEELGEHKEDIYRVNADTSIDYSAYTDEEWEAFDDRTDIHLERLREEGRIFQSIVSLLPSLSVPS
LLVIGDADPVTCDKHVEAYNQMANGHKVVMNNCGHTPHAECPDVYYRIVSAFLLQGEWRFVEMGNGAYTYFNKDVSK

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=113, Percent_Identity=31.858407079646, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35926; Mature: 35926

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYIVRGKKIHVEIFGDRSLPAVLFLHGGPGESCYEFVYHQSNRFSDQFQLVAIDQRGV
CCCEEEECCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
CRSEGLSETEPFGLQDLVEDCEDLRKQLGINRWAVIGHSFGGYLALLYASVYPNAITNVV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHE
FECPTFDFAWTAKSLLRRAASVFLELGIETKSEECLNLATSNLSSEHLFDSYLRLGEELG
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EHKEDIYRVNADTSIDYSAYTDEEWEAFDDRTDIHLERLREEGRIFQSIVSLLPSLSVPS
CHHHHEEEECCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LLVIGDADPVTCDKHVEAYNQMANGHKVVMNNCGHTPHAECPDVYYRIVSAFLLQGEWRF
EEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VEMGNGAYTYFNKDVSK
EEECCCEEEECCCCCCC
>Mature Secondary Structure
MNTYIVRGKKIHVEIFGDRSLPAVLFLHGGPGESCYEFVYHQSNRFSDQFQLVAIDQRGV
CCCEEEECCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
CRSEGLSETEPFGLQDLVEDCEDLRKQLGINRWAVIGHSFGGYLALLYASVYPNAITNVV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHE
FECPTFDFAWTAKSLLRRAASVFLELGIETKSEECLNLATSNLSSEHLFDSYLRLGEELG
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EHKEDIYRVNADTSIDYSAYTDEEWEAFDDRTDIHLERLREEGRIFQSIVSLLPSLSVPS
CHHHHEEEECCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LLVIGDADPVTCDKHVEAYNQMANGHKVVMNNCGHTPHAECPDVYYRIVSAFLLQGEWRF
EEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VEMGNGAYTYFNKDVSK
EEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]