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The map label for this gene is hisC

Identifier: 56963666

GI number: 56963666

Start: 2017743

End: 2018852

Strand: Direct

Name: hisC

Synonym: ABC1901

Alternate gene names: 56963666

Gene position: 2017743-2018852 (Clockwise)

Preceding gene: 56963665

Following gene: 56963667

Centisome position: 46.88

GC content: 46.4

Gene sequence:

>1110_bases
ATGTTAGCAAAAAAACAAATACAAGGGTTGCCGCCTTACGCCCCAGGCAAGCCGATTGAAGATGTAAAAAGGGAATACGG
TTTAGAGACCGTCATAAAAATGGCATCGAATGAAAATCCGTATGGGGCGTCTCCTGCTGTCGCAAAGGCGATTGCCGATG
GAGCATCAAAAACGTTTTTGTATCCGGATGGCTATGGCACAGCCTTGCGCAAAGCACTTGCTGCCAAACATAAAGTAGAT
GAAGGACAGCTTATATTAGGAAATGGCACTGATGAAGTTATTCAACTATTATGCAGAAGTTTTTTAACGCCTGAGACCAA
CACGGTTATGGCGACGCCCTCTTTTTCTCAGTACAAGTTAAATGCAACGATTGAAGGGGCAACGATAAAAGAAATAACCG
TTAAAGAAGACGGCTCTCACGATTTAGATGCGATGCTTGCAGCGATTGACGACCAAACGCGAATTGTATGGGTCTGCAAT
CCGAACAATCCAAATGGGGTCGCACTCGGTGAAGCCGAGTTGAAAACGTTTTTAGACGCCGTGCCAACTACATGTTTGGT
CGTTGTCGATGAAGCTTACTATGAATATGTAGAATTAGATGACTTCCCAAACAGCGTCGCGCTGTTAAATGCATATCCGC
AACTAGTTGTGTTGCGGACGTTCTCAAAAGCATATGGACTTGCAGGCCTCCGCGTCGGCTACGGCATTAGTCAGCGTGAA
ATCGCTCGTCAAATTGAACCTGTGCGATTGCCCTTTAACAACAACATCCTTGCTCACACAGCCGCACTCGCAGCGCTGGA
AGACGAAGCGTTTATTGCGGCGTGCAAGCAAAAAAACAGTGTCGAGAAGGCAAAATTGCGCGCTTTCTTTGAGGCCAGAG
GGATGTTTGTGTTTCCGTCGGAAACAAACTTCTTGCTTGTGGAAACAGGGATTCCGGGAGATGTTGTCTTTCAAGCTTTT
CTTGAAAATGGCTTTATTCTCCGTTCAGGTGAAGCGCTCGGTTACCCGACGGCAATCCGAATTTCCATAGGCAATGAGGC
CGAAAATGATGCCTTTATAGAAAAAGCTCCTGAGATTTTGGACCAGCTCCGTGCAAGCTTAGGCGCATAA

Upstream 100 bases:

>100_bases
ATTCTCTTCTTCATCCCGCTCCGACCTATTAAACAGTTGCTAGTACGCTTAATTTTGCGTAGGATAGCTAGTAAGACTAG
GGAAAGCAGGTGCAGACACG

Downstream 100 bases:

>100_bases
AAAGAGTAGGAGAATAGTATTGACATGAAGCGTACAGCATTTGTTGTCGGGATGGGGTTGATTGGCGGCTCCATCTCGCT
TGCAATTAAGCGCGACCAAG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLAKKQIQGLPPYAPGKPIEDVKREYGLETVIKMASNENPYGASPAVAKAIADGASKTFLYPDGYGTALRKALAAKHKVD
EGQLILGNGTDEVIQLLCRSFLTPETNTVMATPSFSQYKLNATIEGATIKEITVKEDGSHDLDAMLAAIDDQTRIVWVCN
PNNPNGVALGEAELKTFLDAVPTTCLVVVDEAYYEYVELDDFPNSVALLNAYPQLVVLRTFSKAYGLAGLRVGYGISQRE
IARQIEPVRLPFNNNILAHTAALAALEDEAFIAACKQKNSVEKAKLRAFFEARGMFVFPSETNFLLVETGIPGDVVFQAF
LENGFILRSGEALGYPTAIRISIGNEAENDAFIEKAPEILDQLRASLGA

Sequences:

>Translated_369_residues
MLAKKQIQGLPPYAPGKPIEDVKREYGLETVIKMASNENPYGASPAVAKAIADGASKTFLYPDGYGTALRKALAAKHKVD
EGQLILGNGTDEVIQLLCRSFLTPETNTVMATPSFSQYKLNATIEGATIKEITVKEDGSHDLDAMLAAIDDQTRIVWVCN
PNNPNGVALGEAELKTFLDAVPTTCLVVVDEAYYEYVELDDFPNSVALLNAYPQLVVLRTFSKAYGLAGLRVGYGISQRE
IARQIEPVRLPFNNNILAHTAALAALEDEAFIAACKQKNSVEKAKLRAFFEARGMFVFPSETNFLLVETGIPGDVVFQAF
LENGFILRSGEALGYPTAIRISIGNEAENDAFIEKAPEILDQLRASLGA
>Mature_369_residues
MLAKKQIQGLPPYAPGKPIEDVKREYGLETVIKMASNENPYGASPAVAKAIADGASKTFLYPDGYGTALRKALAAKHKVD
EGQLILGNGTDEVIQLLCRSFLTPETNTVMATPSFSQYKLNATIEGATIKEITVKEDGSHDLDAMLAAIDDQTRIVWVCN
PNNPNGVALGEAELKTFLDAVPTTCLVVVDEAYYEYVELDDFPNSVALLNAYPQLVVLRTFSKAYGLAGLRVGYGISQRE
IARQIEPVRLPFNNNILAHTAALAALEDEAFIAACKQKNSVEKAKLRAFFEARGMFVFPSETNFLLVETGIPGDVVFQAF
LENGFILRSGEALGYPTAIRISIGNEAENDAFIEKAPEILDQLRASLGA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=383, Percent_Identity=26.1096605744125, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786816, Length=280, Percent_Identity=24.2857142857143, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=27.6712328767123, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BACSK (Q5WGR9)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175397.1
- ProteinModelPortal:   Q5WGR9
- SMR:   Q5WGR9
- STRING:   Q5WGR9
- EnsemblBacteria:   EBBACT00000047605
- GeneID:   3204578
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1901
- NMPDR:   fig|66692.3.peg.1945
- eggNOG:   COG0079
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- BioCyc:   BCLA66692:ABC1901-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40055; Mature: 40055

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAKKQIQGLPPYAPGKPIEDVKREYGLETVIKMASNENPYGASPAVAKAIADGASKTFL
CCCCHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEE
YPDGYGTALRKALAAKHKVDEGQLILGNGTDEVIQLLCRSFLTPETNTVMATPSFSQYKL
CCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
NATIEGATIKEITVKEDGSHDLDAMLAAIDDQTRIVWVCNPNNPNGVALGEAELKTFLDA
EEEECCCEEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHHHH
VPTTCLVVVDEAYYEYVELDDFPNSVALLNAYPQLVVLRTFSKAYGLAGLRVGYGISQRE
CCCEEEEEEEHHHHHEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCHHH
IARQIEPVRLPFNNNILAHTAALAALEDEAFIAACKQKNSVEKAKLRAFFEARGMFVFPS
HHHHCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEC
ETNFLLVETGIPGDVVFQAFLENGFILRSGEALGYPTAIRISIGNEAENDAFIEKAPEIL
CCCEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
DQLRASLGA
HHHHHHHCC
>Mature Secondary Structure
MLAKKQIQGLPPYAPGKPIEDVKREYGLETVIKMASNENPYGASPAVAKAIADGASKTFL
CCCCHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEE
YPDGYGTALRKALAAKHKVDEGQLILGNGTDEVIQLLCRSFLTPETNTVMATPSFSQYKL
CCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCEEEE
NATIEGATIKEITVKEDGSHDLDAMLAAIDDQTRIVWVCNPNNPNGVALGEAELKTFLDA
EEEECCCEEEEEEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHHHH
VPTTCLVVVDEAYYEYVELDDFPNSVALLNAYPQLVVLRTFSKAYGLAGLRVGYGISQRE
CCCEEEEEEEHHHHHEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCHHH
IARQIEPVRLPFNNNILAHTAALAALEDEAFIAACKQKNSVEKAKLRAFFEARGMFVFPS
HHHHCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEC
ETNFLLVETGIPGDVVFQAFLENGFILRSGEALGYPTAIRISIGNEAENDAFIEKAPEIL
CCCEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
DQLRASLGA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA