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The map label for this gene is folE [H]

Identifier: 56963648

GI number: 56963648

Start: 2002107

End: 2002676

Strand: Direct

Name: folE [H]

Synonym: ABC1883

Alternate gene names: 56963648

Gene position: 2002107-2002676 (Clockwise)

Preceding gene: 56963647

Following gene: 56963649

Centisome position: 46.52

GC content: 47.02

Gene sequence:

>570_bases
ATGGTTGACCACGATAAATTGCAGCAAGCAGTGCGTATGATATTAGAAGCAATTGGCGAAGACCCTGAACGGGAGGGGCT
TGCTGATACCCCTAGAAGGGTAGCGCAAATGTATGAAGAAATGTTCAGCGGTCTCCACGAAGATCCTAGCGAGCATTTAA
AAACGGTGTTTGGCGAAGAGCATGAAGAACTTGTCCTTGTTAAAGACATCCCGTTCTTTTCGATGTGCGAGCATCACCTT
GTACCGTTTTTTGGGAAAGCTCATATTGCTTACATTCCCAAAAATGGCATCGTGACAGGGTTGTCGAAGCTGGCGCGCAC
TGTCGATGGCATAGCAAGAAGGCCGCAAGTACAAGAAAGAATGACAAAAACATTAGCAGATGTGCTCATGTCTACTTTAG
ATGCAAAAGGGGCAATGGTCGTTTTGTCAGCAGAACATATGTGCATGGCAATGAGAGGCATTAAAAAGCCAGGTTCGAAA
ACGGTGACAACAGCGGTGCGCGGCTCATTCGCCAATGACGGGGAAGCGCGTGCGGAAGTATTGCAACTAATCCAAACGAA
GGAGGTATAA

Upstream 100 bases:

>100_bases
ATTGCCAAATGCGATGAGTTCTTTTTGCTTTTCCACTGTTCTTTTGCTACTCTTTAGAAGAGATTTATCCTTTATAAAGA
GTTTTGGTGGAGGGACAAGA

Downstream 100 bases:

>100_bases
CGATGGGGCATGAGAATGATTTTTTTGTTATAAAAGCAAAAGAAAATGGTGTTCAGGTTATTGGCCTTACCCGCGGTTCG
GATACCCGCTTCCACCATTC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MVDHDKLQQAVRMILEAIGEDPEREGLADTPRRVAQMYEEMFSGLHEDPSEHLKTVFGEEHEELVLVKDIPFFSMCEHHL
VPFFGKAHIAYIPKNGIVTGLSKLARTVDGIARRPQVQERMTKTLADVLMSTLDAKGAMVVLSAEHMCMAMRGIKKPGSK
TVTTAVRGSFANDGEARAEVLQLIQTKEV

Sequences:

>Translated_189_residues
MVDHDKLQQAVRMILEAIGEDPEREGLADTPRRVAQMYEEMFSGLHEDPSEHLKTVFGEEHEELVLVKDIPFFSMCEHHL
VPFFGKAHIAYIPKNGIVTGLSKLARTVDGIARRPQVQERMTKTLADVLMSTLDAKGAMVVLSAEHMCMAMRGIKKPGSK
TVTTAVRGSFANDGEARAEVLQLIQTKEV
>Mature_189_residues
MVDHDKLQQAVRMILEAIGEDPEREGLADTPRRVAQMYEEMFSGLHEDPSEHLKTVFGEEHEELVLVKDIPFFSMCEHHL
VPFFGKAHIAYIPKNGIVTGLSKLARTVDGIARRPQVQERMTKTLADVLMSTLDAKGAMVVLSAEHMCMAMRGIKKPGSK
TVTTAVRGSFANDGEARAEVLQLIQTKEV

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=182, Percent_Identity=49.4505494505495, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI4503949, Length=182, Percent_Identity=49.4505494505495, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI66932970, Length=150, Percent_Identity=46.6666666666667, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI66932972, Length=140, Percent_Identity=49.2857142857143, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI1788476, Length=176, Percent_Identity=39.2045454545455, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=187, Percent_Identity=46.524064171123, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321706, Length=186, Percent_Identity=46.7741935483871, Blast_Score=161, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24656782, Length=182, Percent_Identity=46.1538461538462, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24656796, Length=182, Percent_Identity=46.1538461538462, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24656791, Length=182, Percent_Identity=46.1538461538462, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21028; Mature: 21028

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDHDKLQQAVRMILEAIGEDPEREGLADTPRRVAQMYEEMFSGLHEDPSEHLKTVFGEE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
HEELVLVKDIPFFSMCEHHLVPFFGKAHIAYIPKNGIVTGLSKLARTVDGIARRPQVQER
CCCEEEEECCCHHHHHHHHHCCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
MTKTLADVLMSTLDAKGAMVVLSAEHMCMAMRGIKKPGSKTVTTAVRGSFANDGEARAEV
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
LQLIQTKEV
HHHHHHCCC
>Mature Secondary Structure
MVDHDKLQQAVRMILEAIGEDPEREGLADTPRRVAQMYEEMFSGLHEDPSEHLKTVFGEE
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
HEELVLVKDIPFFSMCEHHLVPFFGKAHIAYIPKNGIVTGLSKLARTVDGIARRPQVQER
CCCEEEEECCCHHHHHHHHHCCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
MTKTLADVLMSTLDAKGAMVVLSAEHMCMAMRGIKKPGSKTVTTAVRGSFANDGEARAEV
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
LQLIQTKEV
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]