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The map label for this gene is ycnB [H]

Identifier: 56963552

GI number: 56963552

Start: 1906279

End: 1907667

Strand: Direct

Name: ycnB [H]

Synonym: ABC1787

Alternate gene names: 56963552

Gene position: 1906279-1907667 (Clockwise)

Preceding gene: 56963551

Following gene: 56963553

Centisome position: 44.29

GC content: 43.41

Gene sequence:

>1389_bases
ATGGAGTCTACACAAACAGAAGAGTCAACGTTTAATAAAAAGCCGCTTGTGGCGGTTATGCTAGTAGGCGCATTTATCGC
CATTTTAAATCAAACATTGCTGACAACTGCATTGCCACACTTAATGGTTGATTTGCAAATTAATGAAAACAAAGCTCAAT
GGGTGACGACGATTTTCATGCTTGTTAATGGCATTATGATTCCTATTAGCGCTTTTTTAATTGAGAAATTCAGAACCCGT
TTCTTGTTTTTAACAGCAATGTCGCTTTTCGGCATCGGTACGCTCATTTGCGCTCTTGCTCCTTCCTTTGCTGTTCTTAT
GGGTGGCCGTGTCATTCAAGCAGCAGGAGCAGGCATTATGATGCCACTTATGCAAACGGTCTTTTTATTAATTTTCCCAG
TTGAAAAACGCGGAGCAGCAATGGGGATGGTTGGACTTGTCATTTCCTTTGCCCCAGCTATTGGTCCAACATTGTCTGGC
TGGCTAGTCGAAATGTTTCCATGGACGATCTTATTCTGGATTTTGATTCCTGTCGTTGTCGTTGATATCATTGCCGCCAT
TTTTGTCATCCGCAATGTGACAGAATTGCGTTCGCCAAAACTTGATCTTTTATCGATTATCCTATCAACGCTTGGATTTG
GCGGTCTGTTATTCGGTTTTTCAAATGCTGGGCAAGCTAGTTGGACGAGTCCACTTGTATTTATTCCACTTGCAATCGGC
ATTTGTGCACTCGTGATGTTTATCAAGAGGCAGCTTTTGTTAGAACATCCTATACTGGAGTTCCGTGTCTTTAAATACCC
GCTGTTTACATTGACGACTGGAATCGGCATGCTCGTTTTTGTCTCGCTTGTGGGCCCGGCAACGATTTTGCCACTCTTTA
TTCAAAATATGCAAGGCCATTCCGCCTTAGAAACAGGACTGACGATTCTCCCTGGTGCTGTTTTAATGGGGTTAATGTCG
CCGATTACTGGCCGTATTTTTGATCGGATTGGGGCAAGGTCTTTGTCCATCATAGGCATCGCCCTACTTGTTGTCACATC
ACTTTTATATACGAATTTAAGCGAGTCAACAAGTCTAGTTTATTTAACAGTCGTTTATGCAGTTCGCATGCTCGGGCTTT
CGTTAGTGATGATGCCGGTAACAACCGCAGGACTTAACGTACTGCCACGCGAGCTTATTCCACATGGAACAGCGATGAAT
AATACGATGCGGCAAGTAACTGGCTCAATCGGTACAGCTATTCTTGTAACGATTATGACGGCATCCGCATCGCTTCACAC
CAATGAAGCAATGATCCAAGGAGTCAACAACGCCTTTATCGTAGCGACCGTGTTAAGTTTTATCGGCTTACTACTATCTT
TCTTCATTAAGAAGCCTGCGGCTGTTTAA

Upstream 100 bases:

>100_bases
TACATAAAAGCAGTTCCCCTCGCACGTCCATTTCGTTCGTCCTCAGTAAAACAATGTTTATTACCGACGTTTTAAATTGA
ATGATAAAGAAGGGTAAAAA

Downstream 100 bases:

>100_bases
CGTTTAATGGGGTTGGTTCCCGGGTATGGTTCACTATACACGACAGCCATAGTTGAAAGGGAGAAAGGAGCCGGTAAGGG
TGAAAAAGTATACAGTTGTT

Product: multidrug resistance protein, efflux transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MESTQTEESTFNKKPLVAVMLVGAFIAILNQTLLTTALPHLMVDLQINENKAQWVTTIFMLVNGIMIPISAFLIEKFRTR
FLFLTAMSLFGIGTLICALAPSFAVLMGGRVIQAAGAGIMMPLMQTVFLLIFPVEKRGAAMGMVGLVISFAPAIGPTLSG
WLVEMFPWTILFWILIPVVVVDIIAAIFVIRNVTELRSPKLDLLSIILSTLGFGGLLFGFSNAGQASWTSPLVFIPLAIG
ICALVMFIKRQLLLEHPILEFRVFKYPLFTLTTGIGMLVFVSLVGPATILPLFIQNMQGHSALETGLTILPGAVLMGLMS
PITGRIFDRIGARSLSIIGIALLVVTSLLYTNLSESTSLVYLTVVYAVRMLGLSLVMMPVTTAGLNVLPRELIPHGTAMN
NTMRQVTGSIGTAILVTIMTASASLHTNEAMIQGVNNAFIVATVLSFIGLLLSFFIKKPAAV

Sequences:

>Translated_462_residues
MESTQTEESTFNKKPLVAVMLVGAFIAILNQTLLTTALPHLMVDLQINENKAQWVTTIFMLVNGIMIPISAFLIEKFRTR
FLFLTAMSLFGIGTLICALAPSFAVLMGGRVIQAAGAGIMMPLMQTVFLLIFPVEKRGAAMGMVGLVISFAPAIGPTLSG
WLVEMFPWTILFWILIPVVVVDIIAAIFVIRNVTELRSPKLDLLSIILSTLGFGGLLFGFSNAGQASWTSPLVFIPLAIG
ICALVMFIKRQLLLEHPILEFRVFKYPLFTLTTGIGMLVFVSLVGPATILPLFIQNMQGHSALETGLTILPGAVLMGLMS
PITGRIFDRIGARSLSIIGIALLVVTSLLYTNLSESTSLVYLTVVYAVRMLGLSLVMMPVTTAGLNVLPRELIPHGTAMN
NTMRQVTGSIGTAILVTIMTASASLHTNEAMIQGVNNAFIVATVLSFIGLLLSFFIKKPAAV
>Mature_462_residues
MESTQTEESTFNKKPLVAVMLVGAFIAILNQTLLTTALPHLMVDLQINENKAQWVTTIFMLVNGIMIPISAFLIEKFRTR
FLFLTAMSLFGIGTLICALAPSFAVLMGGRVIQAAGAGIMMPLMQTVFLLIFPVEKRGAAMGMVGLVISFAPAIGPTLSG
WLVEMFPWTILFWILIPVVVVDIIAAIFVIRNVTELRSPKLDLLSIILSTLGFGGLLFGFSNAGQASWTSPLVFIPLAIG
ICALVMFIKRQLLLEHPILEFRVFKYPLFTLTTGIGMLVFVSLVGPATILPLFIQNMQGHSALETGLTILPGAVLMGLMS
PITGRIFDRIGARSLSIIGIALLVVTSLLYTNLSESTSLVYLTVVYAVRMLGLSLVMMPVTTAGLNVLPRELIPHGTAMN
NTMRQVTGSIGTAILVTIMTASASLHTNEAMIQGVNNAFIVATVLSFIGLLLSFFIKKPAAV

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=437, Percent_Identity=25.629290617849, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788710, Length=421, Percent_Identity=25.8907363420428, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081983, Length=404, Percent_Identity=25.4950495049505, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790195, Length=354, Percent_Identity=26.8361581920904, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788392, Length=408, Percent_Identity=28.4313725490196, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323735, Length=326, Percent_Identity=22.6993865030675, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49819; Mature: 49819

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTQTEESTFNKKPLVAVMLVGAFIAILNQTLLTTALPHLMVDLQINENKAQWVTTIFM
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
LVNGIMIPISAFLIEKFRTRFLFLTAMSLFGIGTLICALAPSFAVLMGGRVIQAAGAGIM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
MPLMQTVFLLIFPVEKRGAAMGMVGLVISFAPAIGPTLSGWLVEMFPWTILFWILIPVVV
HHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDIIAAIFVIRNVTELRSPKLDLLSIILSTLGFGGLLFGFSNAGQASWTSPLVFIPLAIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
ICALVMFIKRQLLLEHPILEFRVFKYPLFTLTTGIGMLVFVSLVGPATILPLFIQNMQGH
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SALETGLTILPGAVLMGLMSPITGRIFDRIGARSLSIIGIALLVVTSLLYTNLSESTSLV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
YLTVVYAVRMLGLSLVMMPVTTAGLNVLPRELIPHGTAMNNTMRQVTGSIGTAILVTIMT
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASASLHTNEAMIQGVNNAFIVATVLSFIGLLLSFFIKKPAAV
HHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MESTQTEESTFNKKPLVAVMLVGAFIAILNQTLLTTALPHLMVDLQINENKAQWVTTIFM
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
LVNGIMIPISAFLIEKFRTRFLFLTAMSLFGIGTLICALAPSFAVLMGGRVIQAAGAGIM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
MPLMQTVFLLIFPVEKRGAAMGMVGLVISFAPAIGPTLSGWLVEMFPWTILFWILIPVVV
HHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDIIAAIFVIRNVTELRSPKLDLLSIILSTLGFGGLLFGFSNAGQASWTSPLVFIPLAIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHH
ICALVMFIKRQLLLEHPILEFRVFKYPLFTLTTGIGMLVFVSLVGPATILPLFIQNMQGH
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SALETGLTILPGAVLMGLMSPITGRIFDRIGARSLSIIGIALLVVTSLLYTNLSESTSLV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
YLTVVYAVRMLGLSLVMMPVTTAGLNVLPRELIPHGTAMNNTMRQVTGSIGTAILVTIMT
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASASLHTNEAMIQGVNNAFIVATVLSFIGLLLSFFIKKPAAV
HHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]