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The map label for this gene is accC [H]

Identifier: 56963272

GI number: 56963272

Start: 1632778

End: 1634139

Strand: Direct

Name: accC [H]

Synonym: ABC1507

Alternate gene names: 56963272

Gene position: 1632778-1634139 (Clockwise)

Preceding gene: 56963271

Following gene: 56963273

Centisome position: 37.94

GC content: 47.36

Gene sequence:

>1362_bases
GTGATCAATACAGTATTAATTGCCAACCGTGGCGAAATTGCCTCGCGCATTATCCGTACATGCAAAAAGCTTGGCGTAAA
GACTATCGCTGTTTATTCAGAAGCTGATTGCAATGCAGAACACGTCACGCTTGCCGACGAGGCCTACTGCATTGGCGGTT
CACGTGTCCAGGAGAGCTATTTAAACCAAGAACAGATTTTGGCTGTTGCCAAACAAGCAAAAGCTGATGCCATTCATCCC
GGTTACGGGCTGTTGTCCGAGCAAGCTTCATTTGCGACCGCCTGTAAGGACAATGGGCTAACCTTTATTGGCCCTTCAGC
AACGGCAATTGCGCTGATGGGTGATAAATTGCAAGCTAGAAAGACGATGGAGGCAGCGGGTATCCCTGTTATTCCAGGAA
GTAGCGCTCTTGCCTCAGCAGCAGAAGCAAAGACGAAAGCAAGGGAAATTGGCTTTCCGGTTATGGTCAAAGCCGCTTCA
GGTGGCGGCGGCATCGGCATTGATGTGTGCCGGAATGAAGAGGAAATCGAAGCAGCTTTTGCCCGAAACGAAAAGAAAGC
ACGTATGTTTTTTGGCGACAGCTCTCTTTATTTGGAGAAGTTGCTTGAGCGGCCGCGTCACATTGAAATTCAAGTGCTCG
CTGACAGCGATGGTCATATCCTCGCATTTGGGGAGCGGGAATGTTCCATTCAAAGGAGACATCAAAAAGTTGTTGAAGAA
GCGCCATCTCCTTTTTTAGACCAAACGACCCGTGAGGCGATGGAGGAAATGGCGAAAAAAGCAGCTGCCGCCATTGGTTA
TGAAAATGCTGGCACAATTGAATGTTTGCTAGACAGCGACGGAAATTATTACTTTTTGGAAATGAATACACGGCTGCAAG
TCGAACATCCAGTGACAGAGGAAGTCTTTGGCATTGATCTTGTGGAATGGCAATTGCGGATAGCAAATGGCGATGTGCTG
CCGTGGCAGCAGCATGAGCTCAGAGGCAGCGGCCATGCGATTGAAGTCCGCATTTATGCAGAAGACCCAATACGCTTTTT
CCCTTCGCCTGGGATGATAAAGGACATCTCTCTTCCGAAACAACCTTTTATCCGCCATGAATGTCCGGTGAAAGCAGGAA
GCGTGATTACCCCGTTTTATGATCCGATGATCGCTAAGCTCATTGTTAAAGGGGGCACGCGCAATGAAGCGATTACTCGA
TTAAAGGAAGCGCTCAATGACTATGACATAACAGGGGTAAAAACCAATCTGCCTCTTTTGCGGGCAATATGCGATCACCA
AGCTTTTATTGAAGGCAACACGCCAACATCCTTTTTAAATGATTATAAAGAAGAACTTTTCATAAAGGAGAGAGAAGCAT
GA

Upstream 100 bases:

>100_bases
CCAAGCTATTGGAAATTGGCGAAGGCACTTCGGAAATCCAACGCCTTGTCATTGCTAGGCATTTAGGGTTAGCAGCTTTA
CAGCAAAAGGAGGCGAAACG

Downstream 100 bases:

>100_bases
ACCATATTACAGCGACAATGGCAGGGAACGTTTGGAAAGTTACTGTAAAAGAAGGCGACGAAGTGAAGGCTGGGGATGAA
GTCGCCATTTTAGAATCAAT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MINTVLIANRGEIASRIIRTCKKLGVKTIAVYSEADCNAEHVTLADEAYCIGGSRVQESYLNQEQILAVAKQAKADAIHP
GYGLLSEQASFATACKDNGLTFIGPSATAIALMGDKLQARKTMEAAGIPVIPGSSALASAAEAKTKAREIGFPVMVKAAS
GGGGIGIDVCRNEEEIEAAFARNEKKARMFFGDSSLYLEKLLERPRHIEIQVLADSDGHILAFGERECSIQRRHQKVVEE
APSPFLDQTTREAMEEMAKKAAAAIGYENAGTIECLLDSDGNYYFLEMNTRLQVEHPVTEEVFGIDLVEWQLRIANGDVL
PWQQHELRGSGHAIEVRIYAEDPIRFFPSPGMIKDISLPKQPFIRHECPVKAGSVITPFYDPMIAKLIVKGGTRNEAITR
LKEALNDYDITGVKTNLPLLRAICDHQAFIEGNTPTSFLNDYKEELFIKEREA

Sequences:

>Translated_453_residues
MINTVLIANRGEIASRIIRTCKKLGVKTIAVYSEADCNAEHVTLADEAYCIGGSRVQESYLNQEQILAVAKQAKADAIHP
GYGLLSEQASFATACKDNGLTFIGPSATAIALMGDKLQARKTMEAAGIPVIPGSSALASAAEAKTKAREIGFPVMVKAAS
GGGGIGIDVCRNEEEIEAAFARNEKKARMFFGDSSLYLEKLLERPRHIEIQVLADSDGHILAFGERECSIQRRHQKVVEE
APSPFLDQTTREAMEEMAKKAAAAIGYENAGTIECLLDSDGNYYFLEMNTRLQVEHPVTEEVFGIDLVEWQLRIANGDVL
PWQQHELRGSGHAIEVRIYAEDPIRFFPSPGMIKDISLPKQPFIRHECPVKAGSVITPFYDPMIAKLIVKGGTRNEAITR
LKEALNDYDITGVKTNLPLLRAICDHQAFIEGNTPTSFLNDYKEELFIKEREA
>Mature_453_residues
MINTVLIANRGEIASRIIRTCKKLGVKTIAVYSEADCNAEHVTLADEAYCIGGSRVQESYLNQEQILAVAKQAKADAIHP
GYGLLSEQASFATACKDNGLTFIGPSATAIALMGDKLQARKTMEAAGIPVIPGSSALASAAEAKTKAREIGFPVMVKAAS
GGGGIGIDVCRNEEEIEAAFARNEKKARMFFGDSSLYLEKLLERPRHIEIQVLADSDGHILAFGERECSIQRRHQKVVEE
APSPFLDQTTREAMEEMAKKAAAAIGYENAGTIECLLDSDGNYYFLEMNTRLQVEHPVTEEVFGIDLVEWQLRIANGDVL
PWQQHELRGSGHAIEVRIYAEDPIRFFPSPGMIKDISLPKQPFIRHECPVKAGSVITPFYDPMIAKLIVKGGTRNEAITR
LKEALNDYDITGVKTNLPLLRAICDHQAFIEGNTPTSFLNDYKEELFIKEREA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=455, Percent_Identity=47.4725274725275, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=47.6614699331849, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=47.5555555555556, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=47.5555555555556, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=453, Percent_Identity=45.4746136865342, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=453, Percent_Identity=45.4746136865342, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=453, Percent_Identity=45.4746136865342, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=30.0796812749004, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=30.0796812749004, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=30.0194931773879, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=30.0796812749004, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=30.0796812749004, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=29.7029702970297, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=47.8458049886621, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71987519, Length=449, Percent_Identity=46.7706013363029, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=450, Percent_Identity=45.1111111111111, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.6666666666667, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=455, Percent_Identity=30.7692307692308, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.5283757338552, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.5283757338552, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=44.7427293064877, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=41.0714285714286, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=41.5178571428571, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=32.1961620469083, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=30.0970873786408, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651757, Length=451, Percent_Identity=45.6762749445676, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=43.7777777777778, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=43.7777777777778, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=43.7777777777778, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=43.7777777777778, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=43.7777777777778, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=43.7777777777778, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=43.7777777777778, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=43.7777777777778, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=43.7777777777778, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=43.7777777777778, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=412, Percent_Identity=44.6601941747573, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=30.5835010060362, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=30.5835010060362, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=30.5835010060362, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=30.5835010060362, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49829; Mature: 49829

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTVLIANRGEIASRIIRTCKKLGVKTIAVYSEADCNAEHVTLADEAYCIGGSRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEECCCHHHHHHH
LNQEQILAVAKQAKADAIHPGYGLLSEQASFATACKDNGLTFIGPSATAIALMGDKLQAR
CCHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCCCEEEECCCCEEEEEECCHHHHH
KTMEAAGIPVIPGSSALASAAEAKTKAREIGFPVMVKAASGGGGIGIDVCRNEEEIEAAF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCHHHHHHHH
ARNEKKARMFFGDSSLYLEKLLERPRHIEIQVLADSDGHILAFGERECSIQRRHQKVVEE
HCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
APSPFLDQTTREAMEEMAKKAAAAIGYENAGTIECLLDSDGNYYFLEMNTRLQVEHPVTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCCH
EVFGIDLVEWQLRIANGDVLPWQQHELRGSGHAIEVRIYAEDPIRFFPSPGMIKDISLPK
HHHCCEEEEEEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCEECCCCCCEEECCCCC
QPFIRHECPVKAGSVITPFYDPMIAKLIVKGGTRNEAITRLKEALNDYDITGVKTNLPLL
CCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCHHH
RAICDHQAFIEGNTPTSFLNDYKEELFIKEREA
HHHHCCCEEEECCCCHHHHHHHHHHHHEECCCC
>Mature Secondary Structure
MINTVLIANRGEIASRIIRTCKKLGVKTIAVYSEADCNAEHVTLADEAYCIGGSRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEECCCHHHHHHH
LNQEQILAVAKQAKADAIHPGYGLLSEQASFATACKDNGLTFIGPSATAIALMGDKLQAR
CCHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCCCEEEECCCCEEEEEECCHHHHH
KTMEAAGIPVIPGSSALASAAEAKTKAREIGFPVMVKAASGGGGIGIDVCRNEEEIEAAF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCHHHHHHHH
ARNEKKARMFFGDSSLYLEKLLERPRHIEIQVLADSDGHILAFGERECSIQRRHQKVVEE
HCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
APSPFLDQTTREAMEEMAKKAAAAIGYENAGTIECLLDSDGNYYFLEMNTRLQVEHPVTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCCH
EVFGIDLVEWQLRIANGDVLPWQQHELRGSGHAIEVRIYAEDPIRFFPSPGMIKDISLPK
HHHCCEEEEEEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCEECCCCCCEEECCCCC
QPFIRHECPVKAGSVITPFYDPMIAKLIVKGGTRNEAITRLKEALNDYDITGVKTNLPLL
CCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCHHH
RAICDHQAFIEGNTPTSFLNDYKEELFIKEREA
HHHHCCCEEEECCCCHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]