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The map label for this gene is yhcA [H]

Identifier: 56963244

GI number: 56963244

Start: 1597265

End: 1598746

Strand: Direct

Name: yhcA [H]

Synonym: ABC1479

Alternate gene names: 56963244

Gene position: 1597265-1598746 (Clockwise)

Preceding gene: 56963242

Following gene: 56963245

Centisome position: 37.11

GC content: 44.87

Gene sequence:

>1482_bases
ATGACAGAAAATACACCAACGAAACCGCCATATAAAATGATTGCGATACTGCTTGCAGGTGCATTTATTGCGTTACTAAA
CAATACGTTGCTTAATGTGGCTTTGCCGTCTATCATGGCAGACTTTGATATTTCTCCTGCGACTGTTCAATGGTTAACGA
CTGGCTATATGCTTGTAAATGGAATTCTCATACCCATTACAGCGTTTTTAATCCAAAAATTTTCCGTGCGCGGGCTTTTT
TTAACGGCGATGACATTGTTTACTTTAGGAACCGCATTAGCTGGCTTCTCCCACAGTTTTCCTGTACTGATGGCAGGGCG
TGTCATTCAAGCTTCAGGATCGGCGATTATGATGCCGTTGTTAATGAATGTGATGTTAACATCGTTTCCCGTTGAAAAGC
GCGGATCGGCAATGGGCATTTTTGGCCTCGTCATGGTATTTGCCCCGGCAATTGGCCCGACGTTGTCAGGCTGGATTGTG
GAGCATTATGAATGGCGTGTATTGTTTTATATGATGCTGCCGTTCGCGATTGTTACCCTTTTACTCGCTGTTTTTCGCCT
ATATGACAATAAACAATCGGTGCATACACATTTGGATGTGATGTCTGTTATTTTATCAAGCATCGGTTTTGGCGGGATAT
TGTATGGGTTTAGTGCTGCTGGCGACAAAGGATGGGCTAGCTTAGAAGTGTACGGCACAATCGTCATCGGCGTGGTTGGC
CTTGTGTTGTTTATTACGCGGCAATTTCAATTAGAAAAGCCCATGCTGGACTTTCGGATTTATAAATACCCGATGTTTGC
TTTATCTTCGGCGATTTCGCTTACAGTGACGATGGGCATGTTTGGGGGAATGTTGCTTATGCCGCTTTATATTCAAACGG
TCCGTGGCATTTCGCCTTTCCATGCAGGCTTGCTCATGTTGCCAGGCGCTTTAATCATGGGGGCGATGTCCCCTATCACC
GGACGTTTGTTTGACAAATTTGGCGGGCGCATTTTAGCAATCACTGGCTTGTTGATCACGATTGTTACTTCCTACTTTTT
CACGACATTGGCTCTTGATACTTCTTATACGGAGTTAATTATGTTGTATTCATTTAGGATGTTTGGCATGTCTATGTTGA
TGATGCCTGTCATGACAAATGGTTTAAACCAGCTTCCCGCACGAATGAATCCACACGGAACTGCGATGAATAATACGCTA
AACCAAGTGGCAGGGGCGGTTGGTTCCGCGTTGCTTGTGACGATTATGTCTACACAGACAAGAATCCATGCAGAGGAGCT
AGCTGGGACAATTGATCCTGCGCTTCTCGGCCAACAGGCAATGGTCGAAGGGATCAACGACGCATTCATGGTTACCGTAT
ACGTTTCAATTATTGCGTTAGTACTAGCCTTTTTCATGAAACGGGCAAAACCTGCTGAAGACAGCAATGAAGAGTTGCCA
GGAAGGGCAGAAGACTTGACGGAAGCTCCGAATCATTCTTAA

Upstream 100 bases:

>100_bases
TCCGCTTGAAAAGAGGAATGGAAAGGAGTATGATAAATCTCGTTATTACTATAGAATTGGTGTATATATATTGGACCGAC
AGTTTAGAGGGGGTTATTGA

Downstream 100 bases:

>100_bases
CGAAAACACAAATAAGCTCGCCTCGTTTTATACACGAGGCGAGGTTTTTGCTTTAGCGAAGGGATTTTATCATTCTTGCC
AGCTGGGAAAAGAGAGCCTG

Product: DMT family permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTENTPTKPPYKMIAILLAGAFIALLNNTLLNVALPSIMADFDISPATVQWLTTGYMLVNGILIPITAFLIQKFSVRGLF
LTAMTLFTLGTALAGFSHSFPVLMAGRVIQASGSAIMMPLLMNVMLTSFPVEKRGSAMGIFGLVMVFAPAIGPTLSGWIV
EHYEWRVLFYMMLPFAIVTLLLAVFRLYDNKQSVHTHLDVMSVILSSIGFGGILYGFSAAGDKGWASLEVYGTIVIGVVG
LVLFITRQFQLEKPMLDFRIYKYPMFALSSAISLTVTMGMFGGMLLMPLYIQTVRGISPFHAGLLMLPGALIMGAMSPIT
GRLFDKFGGRILAITGLLITIVTSYFFTTLALDTSYTELIMLYSFRMFGMSMLMMPVMTNGLNQLPARMNPHGTAMNNTL
NQVAGAVGSALLVTIMSTQTRIHAEELAGTIDPALLGQQAMVEGINDAFMVTVYVSIIALVLAFFMKRAKPAEDSNEELP
GRAEDLTEAPNHS

Sequences:

>Translated_493_residues
MTENTPTKPPYKMIAILLAGAFIALLNNTLLNVALPSIMADFDISPATVQWLTTGYMLVNGILIPITAFLIQKFSVRGLF
LTAMTLFTLGTALAGFSHSFPVLMAGRVIQASGSAIMMPLLMNVMLTSFPVEKRGSAMGIFGLVMVFAPAIGPTLSGWIV
EHYEWRVLFYMMLPFAIVTLLLAVFRLYDNKQSVHTHLDVMSVILSSIGFGGILYGFSAAGDKGWASLEVYGTIVIGVVG
LVLFITRQFQLEKPMLDFRIYKYPMFALSSAISLTVTMGMFGGMLLMPLYIQTVRGISPFHAGLLMLPGALIMGAMSPIT
GRLFDKFGGRILAITGLLITIVTSYFFTTLALDTSYTELIMLYSFRMFGMSMLMMPVMTNGLNQLPARMNPHGTAMNNTL
NQVAGAVGSALLVTIMSTQTRIHAEELAGTIDPALLGQQAMVEGINDAFMVTVYVSIIALVLAFFMKRAKPAEDSNEELP
GRAEDLTEAPNHS
>Mature_492_residues
TENTPTKPPYKMIAILLAGAFIALLNNTLLNVALPSIMADFDISPATVQWLTTGYMLVNGILIPITAFLIQKFSVRGLFL
TAMTLFTLGTALAGFSHSFPVLMAGRVIQASGSAIMMPLLMNVMLTSFPVEKRGSAMGIFGLVMVFAPAIGPTLSGWIVE
HYEWRVLFYMMLPFAIVTLLLAVFRLYDNKQSVHTHLDVMSVILSSIGFGGILYGFSAAGDKGWASLEVYGTIVIGVVGL
VLFITRQFQLEKPMLDFRIYKYPMFALSSAISLTVTMGMFGGMLLMPLYIQTVRGISPFHAGLLMLPGALIMGAMSPITG
RLFDKFGGRILAITGLLITIVTSYFFTTLALDTSYTELIMLYSFRMFGMSMLMMPVMTNGLNQLPARMNPHGTAMNNTLN
QVAGAVGSALLVTIMSTQTRIHAEELAGTIDPALLGQQAMVEGINDAFMVTVYVSIIALVLAFFMKRAKPAEDSNEELPG
RAEDLTEAPNHS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=423, Percent_Identity=27.1867612293144, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789042, Length=437, Percent_Identity=25.4004576659039, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081983, Length=368, Percent_Identity=27.7173913043478, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790195, Length=290, Percent_Identity=29.3103448275862, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788392, Length=417, Percent_Identity=28.0575539568345, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323735, Length=326, Percent_Identity=22.3926380368098, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=458, Percent_Identity=22.707423580786, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=238, Percent_Identity=23.109243697479, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53612; Mature: 53481

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHCCCCCCC
>Mature Secondary Structure 
TENTPTKPPYKMIAILLAGAFIALLNNTLLNVALPSIMADFDISPATVQWLTTGYMLVN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH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CCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]