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The map label for this gene is yhcA [H]

Identifier: 56963163

GI number: 56963163

Start: 1504963

End: 1506396

Strand: Direct

Name: yhcA [H]

Synonym: ABC1392

Alternate gene names: 56963163

Gene position: 1504963-1506396 (Clockwise)

Preceding gene: 56963162

Following gene: 56963164

Centisome position: 34.97

GC content: 49.86

Gene sequence:

>1434_bases
TTGACTGACATGCAGGCTTTTTCCATACGAACGATTATCGGTCCTTTAATTGCCGTTGTCGTTGGCATGGTGATGGTCAT
ACTGGACAGCACCATTGTCAATGTGGCTTTTCCAAAGTTTCAACAGGAGTTTGGGAGTACATTGGCTGTCGTGCAGTGGA
CGTTCACCGGCTATACCCTGGCGTTGTCTGCTGTCATTCCACTTGCAGGCTGGATGACGGACAAATTCGGAGCTAAGCGT
ATTTTTTTAACAACCGTTGCGCTCTTTACCTTGGGATCCGTACTATGTGGAATGGCGCAAACCATTGAGCAATTGATTAT
TTTCCGGATTGTGCAAGGTATTGGCGGAGGCATGGTAACTCCGATTGGCATGGCGGTGATATACAGGCTGACGCCGTCCC
ATAAGATAGGGGAAGTAATGGGTGTGCTAGGTATCCCTATCCTGATTGCTCCTGCGCTCGGTCCTGTATTATCGGGTTGG
CTTCTCGATTATGTATCTTGGCAATGGATTTTTCTCATTAATCTGCCGATTGGCATTATAGCCATTGCGTTAGGGATGAA
ATGGTTGCCAGCCTTTCCGCAGGGTGAAGTGCCAAAGCTCGATACACTTGGCATGATACTGGCTCCGTTGGCTTTCTCCA
TGCTGGCCTTTGGAGTAGGCGAAGGGGCCGTAGACTGGACGTCCACCCGCACTGTGGTTGCCCTTACTGTCGGAGCCGCG
GCATTGGTCGGATTGATTGTAACAGAGCTGCGGCACAGGCAGCCTTTGCTTGAATTGCGTGTGTTCAAATCTTCTGATTT
CACACGAGGTATTCTGCTTTTATGGCTTGTGCAAATTGCATTGTTTGGCGTGATGGTCCTGTTTCCGGTATATCTCCAGA
CTGTTCGGGGATATTCGCCGCTTGATACGGGATTGATCATGCTTGCTCAAGCGGTCGGTTCGATCCTTTTCACGCCTGTT
GGGGGGCGTATGTATGACAAGGTGGGCGCCCGTCCGCTGGCGCTGATCGGTTTAACCGCCGTATCCGCTGCGCTTTTCTG
GCTATCGCACGTTTCACCGGAGGCTGGGCTGACAATGCTCTTGCTACCCTTGTTTATGATTGGTTCCGGCATGGGGCTAA
TTATGATGGCGCTAAATACTCACGTCCTCAATTCCGCTCCGCGTGATCTCGTCGGAAGAGTTACTTCACTCACTACAGCA
GCGCAGCATGTAATAACATCTTTCGCGGTAGCGGGGCTTACGGGATTTCTAGCCTATCGAATGAATGAGATGACTATGAA
TGTGGAGTTACAAAGTATTGCCGCAGCTTACAGTGATACGTTTCTATTGACTGCAATATTGGCAGCCATAGGTATCGTTC
TCAGTCTTACACTGCGGAAGCCACAGCTTCTTGATTCAGCCGTTCCGACACAAGGACATGATACCAATAAGTGA

Upstream 100 bases:

>100_bases
CAAACACACAGTTTATGAATATAATGTAACTTGAGATATCTCAAGTTTTTTTACTTTAAACTGTGATTTTAAAAATCACA
GTATGGAAGGGAGGATTCAT

Downstream 100 bases:

>100_bases
ATAAAAGAGAGGAGTTGCTTGTCATGCAGACAACGACACAACAACAGATAGCCAGTTCCGCTACGATAGGCAGAACATTA
ATTGCGGGTTCTGCGGCAGG

Product: major facilitator (MFS) superfamily protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTDMQAFSIRTIIGPLIAVVVGMVMVILDSTIVNVAFPKFQQEFGSTLAVVQWTFTGYTLALSAVIPLAGWMTDKFGAKR
IFLTTVALFTLGSVLCGMAQTIEQLIIFRIVQGIGGGMVTPIGMAVIYRLTPSHKIGEVMGVLGIPILIAPALGPVLSGW
LLDYVSWQWIFLINLPIGIIAIALGMKWLPAFPQGEVPKLDTLGMILAPLAFSMLAFGVGEGAVDWTSTRTVVALTVGAA
ALVGLIVTELRHRQPLLELRVFKSSDFTRGILLLWLVQIALFGVMVLFPVYLQTVRGYSPLDTGLIMLAQAVGSILFTPV
GGRMYDKVGARPLALIGLTAVSAALFWLSHVSPEAGLTMLLLPLFMIGSGMGLIMMALNTHVLNSAPRDLVGRVTSLTTA
AQHVITSFAVAGLTGFLAYRMNEMTMNVELQSIAAAYSDTFLLTAILAAIGIVLSLTLRKPQLLDSAVPTQGHDTNK

Sequences:

>Translated_477_residues
MTDMQAFSIRTIIGPLIAVVVGMVMVILDSTIVNVAFPKFQQEFGSTLAVVQWTFTGYTLALSAVIPLAGWMTDKFGAKR
IFLTTVALFTLGSVLCGMAQTIEQLIIFRIVQGIGGGMVTPIGMAVIYRLTPSHKIGEVMGVLGIPILIAPALGPVLSGW
LLDYVSWQWIFLINLPIGIIAIALGMKWLPAFPQGEVPKLDTLGMILAPLAFSMLAFGVGEGAVDWTSTRTVVALTVGAA
ALVGLIVTELRHRQPLLELRVFKSSDFTRGILLLWLVQIALFGVMVLFPVYLQTVRGYSPLDTGLIMLAQAVGSILFTPV
GGRMYDKVGARPLALIGLTAVSAALFWLSHVSPEAGLTMLLLPLFMIGSGMGLIMMALNTHVLNSAPRDLVGRVTSLTTA
AQHVITSFAVAGLTGFLAYRMNEMTMNVELQSIAAAYSDTFLLTAILAAIGIVLSLTLRKPQLLDSAVPTQGHDTNK
>Mature_476_residues
TDMQAFSIRTIIGPLIAVVVGMVMVILDSTIVNVAFPKFQQEFGSTLAVVQWTFTGYTLALSAVIPLAGWMTDKFGAKRI
FLTTVALFTLGSVLCGMAQTIEQLIIFRIVQGIGGGMVTPIGMAVIYRLTPSHKIGEVMGVLGIPILIAPALGPVLSGWL
LDYVSWQWIFLINLPIGIIAIALGMKWLPAFPQGEVPKLDTLGMILAPLAFSMLAFGVGEGAVDWTSTRTVVALTVGAAA
LVGLIVTELRHRQPLLELRVFKSSDFTRGILLLWLVQIALFGVMVLFPVYLQTVRGYSPLDTGLIMLAQAVGSILFTPVG
GRMYDKVGARPLALIGLTAVSAALFWLSHVSPEAGLTMLLLPLFMIGSGMGLIMMALNTHVLNSAPRDLVGRVTSLTTAA
QHVITSFAVAGLTGFLAYRMNEMTMNVELQSIAAAYSDTFLLTAILAAIGIVLSLTLRKPQLLDSAVPTQGHDTNK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=435, Percent_Identity=32.6436781609195, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789042, Length=387, Percent_Identity=30.2325581395349, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1788710, Length=387, Percent_Identity=30.2325581395349, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI87081983, Length=392, Percent_Identity=28.5714285714286, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788392, Length=466, Percent_Identity=26.6094420600858, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790146, Length=137, Percent_Identity=26.2773722627737, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48994889, Length=154, Percent_Identity=27.9220779220779, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=231, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321663, Length=153, Percent_Identity=30.0653594771242, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323735, Length=313, Percent_Identity=25.2396166134185, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=180, Percent_Identity=26.1111111111111, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=295, Percent_Identity=25.0847457627119, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51042; Mature: 50911

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMQAFSIRTIIGPLIAVVVGMVMVILDSTIVNVAFPKFQQEFGSTLAVVQWTFTGYTL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHH
ALSAVIPLAGWMTDKFGAKRIFLTTVALFTLGSVLCGMAQTIEQLIIFRIVQGIGGGMVT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
PIGMAVIYRLTPSHKIGEVMGVLGIPILIAPALGPVLSGWLLDYVSWQWIFLINLPIGII
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHH
AIALGMKWLPAFPQGEVPKLDTLGMILAPLAFSMLAFGVGEGAVDWTSTRTVVALTVGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHH
ALVGLIVTELRHRQPLLELRVFKSSDFTRGILLLWLVQIALFGVMVLFPVYLQTVRGYSP
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LDTGLIMLAQAVGSILFTPVGGRMYDKVGARPLALIGLTAVSAALFWLSHVSPEAGLTML
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLPLFMIGSGMGLIMMALNTHVLNSAPRDLVGRVTSLTTAAQHVITSFAVAGLTGFLAYR
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNEMTMNVELQSIAAAYSDTFLLTAILAAIGIVLSLTLRKPQLLDSAVPTQGHDTNK
HHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDMQAFSIRTIIGPLIAVVVGMVMVILDSTIVNVAFPKFQQEFGSTLAVVQWTFTGYTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHH
ALSAVIPLAGWMTDKFGAKRIFLTTVALFTLGSVLCGMAQTIEQLIIFRIVQGIGGGMVT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
PIGMAVIYRLTPSHKIGEVMGVLGIPILIAPALGPVLSGWLLDYVSWQWIFLINLPIGII
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHH
AIALGMKWLPAFPQGEVPKLDTLGMILAPLAFSMLAFGVGEGAVDWTSTRTVVALTVGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHH
ALVGLIVTELRHRQPLLELRVFKSSDFTRGILLLWLVQIALFGVMVLFPVYLQTVRGYSP
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LDTGLIMLAQAVGSILFTPVGGRMYDKVGARPLALIGLTAVSAALFWLSHVSPEAGLTML
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLPLFMIGSGMGLIMMALNTHVLNSAPRDLVGRVTSLTTAAQHVITSFAVAGLTGFLAYR
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNEMTMNVELQSIAAAYSDTFLLTAILAAIGIVLSLTLRKPQLLDSAVPTQGHDTNK
HHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]